Ignet

Gene Information

Gene symbol: TCF4

Gene name: transcription factor 4

HGNC ID: 11634

Synonyms: SEF2-1B, ITF2, bHLHb19, E2-2

Related Genes

#	Gene Symbol	Number of hits
1	ATF4	1 hits
2	IL2	1 hits
3	INS	1 hits
4	PAX4	1 hits
5	SLC30A10	1 hits
6	SLC30A8	1 hits
7	STAT4	1 hits
8	TCF7L2	1 hits

Related Sentences

#	PMID	Sentence
1	2785066	Evidence for macrophage-mediated suppression participating in the deficient function of splenic lymphocytes in this mouse model of insulin-dependent diabetes includes: 1) the restoration of mitogen-induced interleukin 2 production after the macrophages have been depleted by silica absorption form spleen cells; 2) the complete suppression of the cell proliferation by thioglycollate-stimulated peritoneal exudate cells from non-obese diabetic and control mice, and the partial suppression by spleen macrophages from non-obese diabetic mice; 3) the reversal of the suppression of interleukin 2 production by the prostaglandin synthetase inhibitor indomethacin (0.1-1 microgram/ml); 4) the partial suppression of interleukin 2 production, conversely, by the exogenous prostaglandins E1 and E2 (2.5 x 10(-6) mol/l).
2	12063257	Activation of the beta-catenin/Lef-Tcf pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acid.
3	12063257	We investigated whether the beta-catenin/Lef-Tcf-sensitive transcriptional pathway activated by Frizzled-1 plays a role in the retinoic acid-induced pathway to primitive endoderm formation.
4	12063257	The stimulation of Lef-Tcf-sensitive transcription as well as the formation of primitive endoderm was accompanied by the stabilization of beta-catenin as observed in activation of the Frizzled-1 pathway.
5	12063257	Transient transfection of F9 cells with an expression vector harboring a dominant-negative mutant of Tcf4 resulted in the attenuation of both the increase in Lef-Tcf-sensitive transcription and formation of primitive endoderm in response to the morphogen.
6	12063257	Clones stably transfected to express the dominant-negative Tcf4 displayed a block in retinoic acid-induced activation of Lef-Tcf-sensitive transcription and primitive endoderm formation.
7	12063257	These data reveal the obligate role of the beta-catenin/Lef-Tcf transcriptional pathway in the action of the morphogen retinoic acid.
8	12063257	Activation of the beta-catenin/Lef-Tcf pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acid.
9	12063257	We investigated whether the beta-catenin/Lef-Tcf-sensitive transcriptional pathway activated by Frizzled-1 plays a role in the retinoic acid-induced pathway to primitive endoderm formation.
10	12063257	The stimulation of Lef-Tcf-sensitive transcription as well as the formation of primitive endoderm was accompanied by the stabilization of beta-catenin as observed in activation of the Frizzled-1 pathway.
11	12063257	Transient transfection of F9 cells with an expression vector harboring a dominant-negative mutant of Tcf4 resulted in the attenuation of both the increase in Lef-Tcf-sensitive transcription and formation of primitive endoderm in response to the morphogen.
12	12063257	Clones stably transfected to express the dominant-negative Tcf4 displayed a block in retinoic acid-induced activation of Lef-Tcf-sensitive transcription and primitive endoderm formation.
13	12063257	These data reveal the obligate role of the beta-catenin/Lef-Tcf transcriptional pathway in the action of the morphogen retinoic acid.
14	14679102	We investigated the signal transduction pathway of IL-12 and showed that lisofylline (LSF) inhibited the signal transducer and activator of transcription factor-4 (STAT4) activation.
15	14679102	Interruption of IL-12-mediated STAT4 activation prevented autoimmune diabetes in NOD mice.
16	20306012	Recent evidence indicates an emerging role for activation transcription factor 4 (ATF4), a master regulator for evolutionarily conserved mammalian stress response pathways, in cardiovascular pathologic settings.
17	20306012	ATF4 is induced in aortic smooth muscle cells by fibroblast growth factor 2 and in the intact vessel wall following balloon angioplasty.
18	20873210	[Polymorphic markers TCF7L2 rs12255372 and SLC30A8 rs13266634 confer susceptibility to type 2 diabetes in a Russian population].
19	20873210	Genes 7CF7L2 and SLC30A8, encoding transcription factor-4 and transmembrane zinc transporter-8, respectively, play an important role in the regulation of development, proliferation, and pancreatic beta cell function.
20	21263211	Paired-homeodomain transcription factor 4 (PAX4) functions as a transcriptional repressor and is involved in the differentiation of insulin-secreting β-cells.
21	21263211	Here we identified a novel PAX4 mutation in a Japanese patient with MODY.
22	21263211	We therefore analyzed several candidate genes of MODY, and identified a novel mutation of a 39-base heterozygous deletion in exon 3 (c.374-412 del39) of PAX4 in the proband and his father.
23	21263211	As expected, luciferase-reporter assays revealed that the mutant PAX4 could not repress the activities of insulin and glucagon gene promoters, unlike the wild-type PAX4 that repressed the promoter activities.