# |
PMID |
Sentence |
1 |
9267469
|
Immunocytochemical evidence that GLUT4 resides in a specialized translocation post-endosomal VAMP2-positive compartment in rat adipose cells in the absence of insulin.
|
2 |
9267469
|
Insulin stimulates glucose transport in rat adipose cells through the translocation of GLUT4 from a poorly defined intracellular compartment to the cell surface.
|
3 |
9267469
|
We employed confocal microscopy to determine the in situ localization of GLUT4 relative to vesicle, Golgi, and endosomal proteins in these physiological insulin target cells.
|
4 |
9267469
|
VAMP2 closely associates with GLUT4 in many punctate vesicle-like structures.
|
5 |
9267469
|
A small fraction of GLUT4 overlaps with TGN38-mannosidase II, gamma-adaptin, and mannose-6-phosphate receptors in the perinuclear region, presumably corresponding to late endosome and trans-Golgi network structures.
|
6 |
9267469
|
GLUT4 does not co-localize with transferrin receptors, clathrin, and Igp-120.
|
7 |
9267469
|
After insulin treatment, GLUT4 partially redistributes to the cell surface and decreases in the perinuclear area.
|
8 |
9267469
|
However, GLUT4 remains co-localized with TGN38-mannosidase II and gamma-adaptin.
|
9 |
9267469
|
Therefore, the basal compartment from which GLUT4 is translocated in response to insulin comprises specialized post-endosomal VAMP2-positive vesicles, distinct from the constitutively recycling endosomes.
|
10 |
9267469
|
Immunocytochemical evidence that GLUT4 resides in a specialized translocation post-endosomal VAMP2-positive compartment in rat adipose cells in the absence of insulin.
|
11 |
9267469
|
Insulin stimulates glucose transport in rat adipose cells through the translocation of GLUT4 from a poorly defined intracellular compartment to the cell surface.
|
12 |
9267469
|
We employed confocal microscopy to determine the in situ localization of GLUT4 relative to vesicle, Golgi, and endosomal proteins in these physiological insulin target cells.
|
13 |
9267469
|
VAMP2 closely associates with GLUT4 in many punctate vesicle-like structures.
|
14 |
9267469
|
A small fraction of GLUT4 overlaps with TGN38-mannosidase II, gamma-adaptin, and mannose-6-phosphate receptors in the perinuclear region, presumably corresponding to late endosome and trans-Golgi network structures.
|
15 |
9267469
|
GLUT4 does not co-localize with transferrin receptors, clathrin, and Igp-120.
|
16 |
9267469
|
After insulin treatment, GLUT4 partially redistributes to the cell surface and decreases in the perinuclear area.
|
17 |
9267469
|
However, GLUT4 remains co-localized with TGN38-mannosidase II and gamma-adaptin.
|
18 |
9267469
|
Therefore, the basal compartment from which GLUT4 is translocated in response to insulin comprises specialized post-endosomal VAMP2-positive vesicles, distinct from the constitutively recycling endosomes.
|