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Gene Information

Gene symbol: TGOLN2

Gene name: trans-golgi network protein 2

HGNC ID: 15450

Synonyms: TGN51, TGN46, TGN48, TGN38, TTGN2

Related Genes

# Gene Symbol Number of hits
1 AP1G1 1 hits
2 SLC2A4 1 hits

Related Sentences

# PMID Sentence
1 9267469 Immunocytochemical evidence that GLUT4 resides in a specialized translocation post-endosomal VAMP2-positive compartment in rat adipose cells in the absence of insulin.
2 9267469 Insulin stimulates glucose transport in rat adipose cells through the translocation of GLUT4 from a poorly defined intracellular compartment to the cell surface.
3 9267469 We employed confocal microscopy to determine the in situ localization of GLUT4 relative to vesicle, Golgi, and endosomal proteins in these physiological insulin target cells.
4 9267469 VAMP2 closely associates with GLUT4 in many punctate vesicle-like structures.
5 9267469 A small fraction of GLUT4 overlaps with TGN38-mannosidase II, gamma-adaptin, and mannose-6-phosphate receptors in the perinuclear region, presumably corresponding to late endosome and trans-Golgi network structures.
6 9267469 GLUT4 does not co-localize with transferrin receptors, clathrin, and Igp-120.
7 9267469 After insulin treatment, GLUT4 partially redistributes to the cell surface and decreases in the perinuclear area.
8 9267469 However, GLUT4 remains co-localized with TGN38-mannosidase II and gamma-adaptin.
9 9267469 Therefore, the basal compartment from which GLUT4 is translocated in response to insulin comprises specialized post-endosomal VAMP2-positive vesicles, distinct from the constitutively recycling endosomes.
10 9267469 Immunocytochemical evidence that GLUT4 resides in a specialized translocation post-endosomal VAMP2-positive compartment in rat adipose cells in the absence of insulin.
11 9267469 Insulin stimulates glucose transport in rat adipose cells through the translocation of GLUT4 from a poorly defined intracellular compartment to the cell surface.
12 9267469 We employed confocal microscopy to determine the in situ localization of GLUT4 relative to vesicle, Golgi, and endosomal proteins in these physiological insulin target cells.
13 9267469 VAMP2 closely associates with GLUT4 in many punctate vesicle-like structures.
14 9267469 A small fraction of GLUT4 overlaps with TGN38-mannosidase II, gamma-adaptin, and mannose-6-phosphate receptors in the perinuclear region, presumably corresponding to late endosome and trans-Golgi network structures.
15 9267469 GLUT4 does not co-localize with transferrin receptors, clathrin, and Igp-120.
16 9267469 After insulin treatment, GLUT4 partially redistributes to the cell surface and decreases in the perinuclear area.
17 9267469 However, GLUT4 remains co-localized with TGN38-mannosidase II and gamma-adaptin.
18 9267469 Therefore, the basal compartment from which GLUT4 is translocated in response to insulin comprises specialized post-endosomal VAMP2-positive vesicles, distinct from the constitutively recycling endosomes.