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Gene Information
Gene symbol: TICAM2
Gene name: toll-like receptor adaptor molecule 2
HGNC ID: 21354
Synonyms: TRAM, TICAM-2, TIRP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IGF1 | 1 hits |
| 2 | INS | 1 hits |
| 3 | IRF3 | 1 hits |
| 4 | IRS2 | 1 hits |
| 5 | MYD88 | 1 hits |
| 6 | TICAM1 | 1 hits |
| 7 | TLR4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 10480623 | Insulin receptor substrate-2 (IRS-2) belongs to a family of cytoplasmic adaptor proteins, which link insulin, IGF-1, and cytokine receptor tyrosine kinases to signaling pathways regulating metabolism, growth, and differentiation (1-3). |
| 2 | 14682250 | Insulin receptor substrate-2(IRS-2) belongs to a family of cytoplasmic adaptor proteins, which link insulin, insulin-like growth factor-1(IGF-1), and cytokine receptor tyrosine kinases to signaling pathways regulating metabolism, growth, differentiation, reproduction, and homestasis. |
| 3 | 22874765 | Thus we evaluated the effect of high glucose on TLR2 and TLR4 expression in mouse mesangial cells (MMC) in vitro. |
| 4 | 22874765 | Furthermore, expression of a TLR4 downstream signaling cascade including myeloid differentiation factor 88 (MyD88), interferon regulatory factor 3 (IRF3), and Toll interleukin receptor domain containing adaptor inducing interferon-β (TRIF)-related adaptor molecule (TRAM) were significantly increased in cells exposed to 25 mM glucose (P < 0.05). |
| 5 | 22874765 | There was also a significant increase in NF-κB activation along with increased secretion of inflammatory cytokines IL-6 and monocyte chemotactic protein-1. |