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Gene Information
Gene symbol: TIMP4
Gene name: TIMP metallopeptidase inhibitor 4
HGNC ID: 11823
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | COL11A1 | 1 hits |
| 2 | EDN1 | 1 hits |
| 3 | ITGB7 | 1 hits |
| 4 | LAMC1 | 1 hits |
| 5 | MMP10 | 1 hits |
| 6 | MMP2 | 1 hits |
| 7 | MMP3 | 1 hits |
| 8 | MMP7 | 1 hits |
| 9 | MMP9 | 1 hits |
| 10 | PRKCA | 1 hits |
| 11 | TIMP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11916931 | In mice on standard diet, with the exception of MMP-8, all MMP and TIMP transcripts were detected in both gonadal and subcutaneous depots. |
| 2 | 11916931 | In obese mice, the expression of MMP-3, -11, -12, -13, and -14 and TIMP-1 mRNAs was upregulated, whereas that of MMP-7, -9, -16, and -24 and TIMP-4 was downregulated. |
| 3 | 11916931 | Thus, the adipose tissue expresses a large array of MMPs and TIMPs, which modulate adipocyte differentiation. |
| 4 | 18780770 | Glomerular MMP-2 and MMP-9 activities as well as TIMP-1 expression were increased robustly in diabetic mice and normalized with CZ treatment. |
| 5 | 18780770 | Interestingly, TIMP-4 expression was opposite to that of TIMP-1 in diabetic and CZ-treated groups. |
| 6 | 19376102 | Polymorphisms of MMP-3 and TIMP-4 genes affect angiographic coronary plaque progression in non-diabetic and type 2 diabetic patients. |
| 7 | 20029543 | Biochemical data showed that this treatment significantly prevented important changes, such as inhibition of MMP-2 and MMP-9 activity, loss of tissue inhibitor of matrix metalloproteinase-4 (TIMP-4) protein, increase in tissue levels of thiol oxidation, endothelin-1, protein kinase C (PKC), and cAMP production, and decrease in tissue level of nitrite. |
| 8 | 21984919 | Compared with the healthy control mice, diabetic mice had significantly fewer c-kit+ stem cells, and these cells had a lower potency of endothelial differentiation; however, the production of the angiogenic growth factor VEGF did not differ between groups. |
| 9 | 21984919 | A pathway-focused array showed that the c-kit+ stem cells from diabetic mice had up-regulated expression levels of many inflammatory factors, including Tlr4, Cxcl9, Il9, Tgfb1, Il4, and Tnfsf5, but no obvious change in the expression levels of cell cycle molecules. |
| 10 | 21984919 | Interestingly, diabetes-related alterations of the extracellular matrix and adhesion molecules were varied; Pecam, Mmp10, Lamc1, Itgb7, Mmp9, and Timp4 were up-regulated, but Col11a1, Fn1, Admts2, and Itgav were down-regulated. |
| 11 | 23959989 | Here, we describe the method of ESC culture and differentiation, and the expression of MMP9 and its inhibitor, tissue inhibitor of metalloproteinase-4 (TIMP4) in differentiating ESC. |