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Gene Information
Gene symbol: TLR5
Gene name: toll-like receptor 5
HGNC ID: 11851
Synonyms: TIL3, SLEB1, FLJ10052, MGC126430, MGC126431
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | FLG | 1 hits |
| 2 | INS | 1 hits |
| 3 | SPG7 | 1 hits |
| 4 | TLR2 | 1 hits |
| 5 | TLR3 | 1 hits |
| 6 | TLR4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16728431 | Expression of TLR3 and TLR5 was significantly higher in newly diabetic non-obese diabetic (NOD) mice when compared with pre-diabetic and control strains of mice. |
| 2 | 16728431 | Dysregulation of TLR4 expression in the diabetic state correlated with increased nuclear factor kappa B (NF-kappaB) activation in response to the TLR4 ligand LPS and higher expression of IL-12p40, tumor necrosis factor alpha (TNFalpha), IL-6 and inducible nitric oxide synthase but lowered expression of IL-10. |
| 3 | 16728431 | Exposure of bone marrow precursor cells from NOD mice to a hyperglycemic environment during differentiation into macrophages resulted in elevated levels of TLR2 and TLR4 and the cytokine TNFalpha. |
| 4 | 20203013 | Here, we show that mice genetically deficient in Toll-like receptor 5 (TLR5), a component of the innate immune system that is expressed in the gut mucosa and that helps defend against infection, exhibit hyperphagia and develop hallmark features of metabolic syndrome, including hyperlipidemia, hypertension, insulin resistance, and increased adiposity. |
| 5 | 20203013 | Food restriction prevented obesity, but not insulin resistance, in the TLR5-deficient mice. |
| 6 | 20203013 | Here, we show that mice genetically deficient in Toll-like receptor 5 (TLR5), a component of the innate immune system that is expressed in the gut mucosa and that helps defend against infection, exhibit hyperphagia and develop hallmark features of metabolic syndrome, including hyperlipidemia, hypertension, insulin resistance, and increased adiposity. |
| 7 | 20203013 | Food restriction prevented obesity, but not insulin resistance, in the TLR5-deficient mice. |
| 8 | 22367599 | Toll-like receptor (TLR) ligands (TLR2: peptidoglycan, PGN; TLR4: lipopolysaccharide, LPS; TLR5: flagellin, FLG) were used to stimulate alveolar macrophages (AMs), and TNF-α production was measured. |
| 9 | 22367599 | Under hyperglycemic conditions and PGN or FLG stimulation, TNF-α production from AMs was significantly reduced in group B compared with group A. |
| 10 | 23455496 | Mice lacking Tlr5 (T5KO) develop insulin resistance and increased adiposity. |