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Gene Information
Gene symbol: TNFSF13B
Gene name: tumor necrosis factor (ligand) superfamily, member 13b
HGNC ID: 11929
Synonyms: BAFF, THANK, BLYS, TALL-1, TALL1, CD257
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD4 | 1 hits |
| 2 | CD40LG | 1 hits |
| 3 | IL17A | 1 hits |
| 4 | INS | 1 hits |
| 5 | NOTCH2 | 1 hits |
| 6 | TNF | 1 hits |
| 7 | TNFRSF11A | 1 hits |
| 8 | TNFRSF13C | 1 hits |
| 9 | TNFRSF4 | 1 hits |
| 10 | TNFRSF9 | 1 hits |
| 11 | TNFSF11 | 1 hits |
| 12 | TNFSF4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14993936 | As there were often parallel sessions, this report discusses selected symposia: STAT as a target for the treatment of cancer, Innate immunity, SOCS and c-CBL: Negative regulation, Tumor immunity, CNS disease, Cellular therapy with adult stem cells and Drug development. |
| 2 | 14993936 | Presentations considering new therapeutic targets (BAFF, and interleukin-17, -21 and -31) are also considered. |
| 3 | 19018006 | Moreover, in vivo BLyS neutralization: 1) restored negative selection at the TR-->FO checkpoint, 2) abrogated serum insulin autoantibodies, 3) reduced the severity of islet inflammation, 4) significantly reduced the incidence of spontaneous diabetes, 5) arrested the terminal stages of islet cell destruction, and 6) disrupted CD4 T cell activation in NOD mice. |
| 4 | 19707732 | They were found to be considerably more active in inhibiting this interaction than the tumor necrosis factor (TNF)-R1-TNF-alpha or B cell-activating factor (BAFF)-R-BAFF interaction, which are members of the same family. |
| 5 | 19707732 | They specifically inhibited CD154-induced cell responses in human B cells as well as in THP-1 myeloid cells, which can serve as surrogate dendritic cells, at concentrations well below their cytotoxic concentrations determined in the same cells. |
| 6 | 19707732 | Flow cytometry experiments confirmed their ability to inhibit the CD154-induced, but not the Staphylococcus aureus Cowan I- or phorbol 12-myristate 13-acetate-induced increase in the surface expression of CD54, CD40, and major histocompatibility complex class II. |
| 7 | 20636329 | Binding experiments showed that it not only inhibits the CD40-CD154 interaction with sub-micromolar activity, but it also has considerably more than 100-fold selectivity toward this interaction even when compared to other members of the tumor necrosis factor superfamily pairs such as TNF-R1-TNF-α, BAFF-R(CD268)-BAFF(CD257/BLys), OX40(CD134)-OX40L(CD252), RANK(CD265)-RANKL(CD254/TRANCE), or 4-1BB(CD137)-4-1BBL. |
| 8 | 23740954 | Differentiation of B cells into the MZ subset is governed by BCR signal strength and specificity, NF-κB activation through the B cell-activating factor belonging to the TNF family (BAFF) receptor, Notch2 signaling, and migration signals mediated by chemokine, integrin, and sphingosine-1-phosphate receptors. |
| 9 | 23740954 | Analysis of microarray expression data indicated that NOD MZ and precursor transitional 2-MZ subsets were particularly dysregulated for genes controlling cellular trafficking, including Apoe, Ccbp2, Cxcr7, Lgals1, Pla2g7, Rgs13, S1pr3, Spn, Bid, Cd55, Prf1, and Tlr3. |