- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: TNFSF4
Gene name: tumor necrosis factor (ligand) superfamily, member 4
HGNC ID: 11934
Synonyms: OX-40L, gp34, CD252
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | APOE | 1 hits |
| 2 | BANK1 | 1 hits |
| 3 | CCL5 | 1 hits |
| 4 | CD40LG | 1 hits |
| 5 | HLA-A | 1 hits |
| 6 | ICA1 | 1 hits |
| 7 | IFNG | 1 hits |
| 8 | IRF5 | 1 hits |
| 9 | KEL | 1 hits |
| 10 | PTPN22 | 1 hits |
| 11 | TNFRSF11A | 1 hits |
| 12 | TNFRSF13C | 1 hits |
| 13 | TNFRSF4 | 1 hits |
| 14 | TNFRSF9 | 1 hits |
| 15 | TNFSF11 | 1 hits |
| 16 | TNFSF13B | 1 hits |
| 17 | UBE2L3 | 1 hits |
| 18 | XKR6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17016617 | Multivariable logistic regression analysis and a stepwise forward selection procedure revealed that 11 different polymorphisms were significantly (P < 0.005) associated with ACI in women or men or in individuals with or without hyper-tension, hypercholesterolemia, or diabetes mellitus: the 584C-->T polymorphism of LIPG, 5665G-->T of EDN1, and G-->A of CCL11 in women; 677C-->T of MTHFR, 1323C-->T of ITGB2, 3932T-->C of APOE, and -231A-->G of EDNRA in men; -572 G -->C of IL6 in hypertensive individuals; -403G-->A of CCL5 and G-->A of COMT in individuals with hypercholesterolemia; and 3932T--> C of APOE and A-->G of TNFSF4 in diabetic individuals. |
| 2 | 19217323 | In the pancreas, iNKT cells expressed the OX40 molecule and promoted type I interferon (IFN) production by plasmacytoid dendritic cells (pDCs) through OX40-OX40 ligand interaction. |
| 3 | 20636329 | Binding experiments showed that it not only inhibits the CD40-CD154 interaction with sub-micromolar activity, but it also has considerably more than 100-fold selectivity toward this interaction even when compared to other members of the tumor necrosis factor superfamily pairs such as TNF-R1-TNF-α, BAFF-R(CD268)-BAFF(CD257/BLys), OX40(CD134)-OX40L(CD252), RANK(CD265)-RANKL(CD254/TRANCE), or 4-1BB(CD137)-4-1BBL. |
| 4 | 20962850 | Our results replicate previously reported associations to alleles of interferon regulatory factor 5 (IRF5), major histocompatibility complex (MHC), tumor necrosis factor (ligand) superfamily member 4 (TNFSF4), Kell blood group complex subunit-related family member 6 (XKR6), B-cell scaffold protein with ankyrin repeats 1 (BANK1), protein tyrosine phosphatase non-receptor type 22 (PTPN22), ubiquitin-conjugating enzyme E2L 3 (UBE2L3) and islet cell autoantigen 1 (ICA1). |
| 5 | 20962850 | We also identify putative associations to cytotoxic T-lymphocyte-associated protein 4 (CTLA4), a gene associated with several autoimmune disorders, and ERBB3, a locus on 12q13 that was previously reported to be associated with type 1 diabetes. |
| 6 | 23184501 | Tumor necrosis factor superfamily member 4 (TNFSF4) plays a key role in the process of atherosclerosis, a common risk factor for both myocardial and cerebral infarctions. |