Ignet

Gene Information

Gene symbol: TP63

Gene name: tumor protein p63

HGNC ID: 15979

Synonyms: p51, SHFM4, EEC3, p63, p73L, OFC8, KET, p73H, NBP, p53CP

Related Genes

#	Gene Symbol	Number of hits
1	AAVS1	1 hits
2	ACTB	1 hits
3	AMACR	1 hits
4	APLP2	1 hits
5	AR	1 hits
6	BRCA1	1 hits
7	CD44	1 hits
8	CD68	1 hits
9	CDKN1C	1 hits
10	CEACAM5	1 hits
11	CSF1	1 hits
12	DDIT3	1 hits
13	DES	1 hits
14	DYNC1H1	1 hits
15	ERBB2	1 hits
16	FOS	1 hits
17	GPR180	1 hits
18	HAGH	1 hits
19	HIST1H2BO	1 hits
20	HIST2H2BE	1 hits
21	HSPG2	1 hits
22	IGF1	1 hits
23	IGFALS	1 hits
24	IGFBP2	1 hits
25	IL1A	1 hits
26	IL2	1 hits
27	INS	1 hits
28	KRT20	1 hits
29	KRT5	1 hits
30	MDK	1 hits
31	MLLT3	1 hits
32	MME	1 hits
33	MUC1	1 hits
34	MUC2	1 hits
35	MUC5AC	1 hits
36	MUC6	1 hits
37	OAS2	1 hits
38	PCNA	1 hits
39	PDGFB	1 hits
40	PDGFRA	1 hits
41	PGR	1 hits
42	S100A1	1 hits
43	SLC9A3R2	1 hits
44	SMARCA1	1 hits
45	TP53	1 hits
46	TP73	1 hits
47	VIM	1 hits

Related Sentences

#	PMID	Sentence
1	7822811	Here we 1) map the fine specificity of these T cells, 2) delineate a homologous peptide sequence near the N-terminus of p69, and 3) demonstrate T cell recognition of this p69 sequence (T cell epitope p69, Tep69) by patient T cells.
2	7822811	Whereas BSA triggers T cell proliferation, recombinant p69 and a synthetic Tep69 peptide induce early stages of T cell activation (IL-2R transcription) but insufficient IL-2 production and thus anergy.
3	9032395	The Rep proteins of adeno-associated virus type 2 (AAV) are known to bind to Rep recognition sequences (RRSs) in the AAV inverted terminal repeats (ITRs), the AAV p5 promoter, and the preferred AAV integration site in human chromosome 19, called AAVS1.
4	9032395	We used the 16-mer core sequences of the RRSs in the AAV ITRs and AAVS1 separately as query sequences and identified 18 new RRSs in or flanking the genes coding for the following: tyrosine kinase activator protein 1 (TKA-1); colony stimulating factor-1; insulin-like growth factor binding protein 2 (IGFBP-2); histone H2B.1; basement membrane heparan sulfate proteoglycan, also known as perlecan; the AF-9 gene product, which is involved in the chromosomal translocation t (9:11)(p22:q23); the betaB subunit of the hormone known as inhibin; interleukin-2 enhancer binding factor; an endoplasmic reticulum-Golgi intermediate compartment resident protein called p63; a global transcription activator (hSNF2L); the beta-actin repair domain; a retinoic acid-inducible factor, also known as midkine; a breast tumor autoantigen; a growth-arrest- and DNA-damage-inducible protein called gadd45; the cyclin-dependent kinase inhibitor called KIP2, which inhibits several G1 cyclin-cyclin-dependent kinase complexes; and the hereditary breast and ovarian cancer gene (BRCA1).
5	16831876	Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family.
6	16831876	The p53 family proteins are transcription factors and have both common and distinct functions. p53 is a classic tumor suppressor, whereas p63 and p73 have fundamental functions in development.
7	16831876	To gain an insight into the functional diversities among the p53 family, target genes specifically regulated by p63 and p73 were examined.
8	16831876	Here, we found that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73.
9	16831876	Accordingly, a specific responsive element was found in intron 1 of the GLX2 gene, which can be activated and bound by p63 and p73.
10	16831876	Interestingly, a deficiency in GLX2 also enhances the susceptibility of a cell to DNA damage-induced apoptosis in a p53-dependent manner.
11	16831876	Given that methylglyoxal is frequently generated under both physiological and pathological conditions, we postulate that GLX2 serves as a pro-survival factor of the p53 family and plays a critical role in the normal development and in the pathogenesis of various human diseases, including cancer, diabetes, and neurodegenerative diseases.
12	16831876	Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family.
13	16831876	The p53 family proteins are transcription factors and have both common and distinct functions. p53 is a classic tumor suppressor, whereas p63 and p73 have fundamental functions in development.
14	16831876	To gain an insight into the functional diversities among the p53 family, target genes specifically regulated by p63 and p73 were examined.
15	16831876	Here, we found that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73.
16	16831876	Accordingly, a specific responsive element was found in intron 1 of the GLX2 gene, which can be activated and bound by p63 and p73.
17	16831876	Interestingly, a deficiency in GLX2 also enhances the susceptibility of a cell to DNA damage-induced apoptosis in a p53-dependent manner.
18	16831876	Given that methylglyoxal is frequently generated under both physiological and pathological conditions, we postulate that GLX2 serves as a pro-survival factor of the p53 family and plays a critical role in the normal development and in the pathogenesis of various human diseases, including cancer, diabetes, and neurodegenerative diseases.
19	16831876	Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family.
20	16831876	The p53 family proteins are transcription factors and have both common and distinct functions. p53 is a classic tumor suppressor, whereas p63 and p73 have fundamental functions in development.
21	16831876	To gain an insight into the functional diversities among the p53 family, target genes specifically regulated by p63 and p73 were examined.
22	16831876	Here, we found that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73.
23	16831876	Accordingly, a specific responsive element was found in intron 1 of the GLX2 gene, which can be activated and bound by p63 and p73.
24	16831876	Interestingly, a deficiency in GLX2 also enhances the susceptibility of a cell to DNA damage-induced apoptosis in a p53-dependent manner.
25	16831876	Given that methylglyoxal is frequently generated under both physiological and pathological conditions, we postulate that GLX2 serves as a pro-survival factor of the p53 family and plays a critical role in the normal development and in the pathogenesis of various human diseases, including cancer, diabetes, and neurodegenerative diseases.
26	16831876	Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family.
27	16831876	The p53 family proteins are transcription factors and have both common and distinct functions. p53 is a classic tumor suppressor, whereas p63 and p73 have fundamental functions in development.
28	16831876	To gain an insight into the functional diversities among the p53 family, target genes specifically regulated by p63 and p73 were examined.
29	16831876	Here, we found that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73.
30	16831876	Accordingly, a specific responsive element was found in intron 1 of the GLX2 gene, which can be activated and bound by p63 and p73.
31	16831876	Interestingly, a deficiency in GLX2 also enhances the susceptibility of a cell to DNA damage-induced apoptosis in a p53-dependent manner.
32	16831876	Given that methylglyoxal is frequently generated under both physiological and pathological conditions, we postulate that GLX2 serves as a pro-survival factor of the p53 family and plays a critical role in the normal development and in the pathogenesis of various human diseases, including cancer, diabetes, and neurodegenerative diseases.
33	16831876	Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family.
34	16831876	The p53 family proteins are transcription factors and have both common and distinct functions. p53 is a classic tumor suppressor, whereas p63 and p73 have fundamental functions in development.
35	16831876	To gain an insight into the functional diversities among the p53 family, target genes specifically regulated by p63 and p73 were examined.
36	16831876	Here, we found that the GLX2 gene, which encodes glyoxalase II enzyme, is up-regulated by p63 and p73.
37	16831876	Accordingly, a specific responsive element was found in intron 1 of the GLX2 gene, which can be activated and bound by p63 and p73.
38	16831876	Interestingly, a deficiency in GLX2 also enhances the susceptibility of a cell to DNA damage-induced apoptosis in a p53-dependent manner.
39	16831876	Given that methylglyoxal is frequently generated under both physiological and pathological conditions, we postulate that GLX2 serves as a pro-survival factor of the p53 family and plays a critical role in the normal development and in the pathogenesis of various human diseases, including cancer, diabetes, and neurodegenerative diseases.
40	20041964	Immunocytochemical methods for the localization of cell proliferation antigen (PCNA), androgen receptor (AR) and p63 protein were carried out, and apoptotic cells were identified by TUNEL essay.
41	20041964	Insulin treatment was effective in preventing testosterone decrease, p63-positive cell increase and apoptotic rates, but did not interfere in cell proliferation.
42	20041964	Immunocytochemical methods for the localization of cell proliferation antigen (PCNA), androgen receptor (AR) and p63 protein were carried out, and apoptotic cells were identified by TUNEL essay.
43	20041964	Insulin treatment was effective in preventing testosterone decrease, p63-positive cell increase and apoptotic rates, but did not interfere in cell proliferation.
44	22076171	Immunohistochemical results of the tumor were as follows: α-methylacyl-coenzyme A rasemase (AMACR) +++, vimentin +++, cytokeratin (CK) 18 +++, CD10 +++, S-100 protein +, MUC1 ++, MUC2 ++, MUC5AC ++, MUC6 ++, panCK Cam5.2 +, CK7 +, CK8 +, CK14 +, CK19 +, CK20 +, p53 +, HepPar1 +, CD68 +, platelet-derived growth factor-α (PDGFRA) +, PanCK AE1/3 -, PanCK WSS -, PanCK MNF115 -, CK 35BE12 -, CK5/6 -, EMA -, desmin -, smooth muscle antigen -, α-fetoprotein -, CEA -, estrogen receptor -, progesterone receptor -, HER2 -, p63 -, and KIT -.
45	22076171	These results suggest that OPRCC can express colloidal iron, low molecular weight CKs, S100 protein, MUC1, MUC2, MUC5AC, MUC6, p53, PDGFRA, and HepPar1.
46	23729543	Mutations in SLC29A3 lead to pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) and H syndromes, familial Rosai-Dorfman disease, and histiocytosis-lymphadenopathy plus syndrome.
47	23729543	PHID syndrome is a novel monogenic autoinflammatory syndrome (AIS) associated with severe elevation of serum amyloid.
48	23729543	In contrast to other AIS, blockade of interleukin-1 and tumor necrosis-α was ineffective.
49	23729543	Mutations in SLC29A3 lead to pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) and H syndromes, familial Rosai-Dorfman disease, and histiocytosis-lymphadenopathy plus syndrome.
50	23729543	PHID syndrome is a novel monogenic autoinflammatory syndrome (AIS) associated with severe elevation of serum amyloid.
51	23729543	In contrast to other AIS, blockade of interleukin-1 and tumor necrosis-α was ineffective.