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Gene Information
Gene symbol: TRIM72
Gene name:
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | IRS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23354051 | Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. |
| 2 | 23354051 | Here we show in mice that muscle-specific mitsugumin 53 (MG53; also called TRIM72) mediates the degradation of the insulin receptor and insulin receptor substrate 1 (IRS1), and when upregulated, causes metabolic syndrome featuring insulin resistance, obesity, hypertension and dyslipidaemia. |
| 3 | 23354051 | Conversely, ablation of MG53 prevents diet-induced metabolic syndrome by preserving the insulin receptor, IRS1 and insulin signalling integrity. |
| 4 | 23354051 | Mechanistically, MG53 acts as an E3 ligase targeting the insulin receptor and IRS1 for ubiquitin-dependent degradation, comprising a central mechanism controlling insulin signal strength in skeletal muscle. |