Ignet

Gene Information

Gene symbol: TRPC3

Gene name: transient receptor potential cation channel, subfamily C, member 3

HGNC ID: 12335

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	BAD	1 hits
3	ORAI1	1 hits
4	STIM1	1 hits
5	TRPC1	1 hits
6	TRPC4	1 hits
7	TRPC5	1 hits
8	TRPC6	1 hits
9	TRPM7	1 hits
10	TRPV1	1 hits
11	TRPV4	1 hits
12	VCAM1	1 hits

Related Sentences

#	PMID	Sentence
1	17434294	Evidence suggests that dysregulation of TRPC4 and -C1 results in vascular endothelial barrier dysfunction; malfunction of TRPP1 and -P2 impairs endothelial NO synthase; the reduced expression or activity of TRPC4 and -V1 impairs agonist-induced vascular relaxation; the decreased activity of TRPV4 reduces flow-induced vascular responses; and the activity of TRPC3 and -C4 is associated with oxidative stress-induced endothelial damage.
2	17699555	In cultured human MCs, high glucose significantly reduced expression of TRPC6 protein, but there was no effect on either TRPC1 or TRPC3.
3	17699555	In glomeruli isolated from streptozotocin-induced diabetic rats, TRPC6, but not TRPC1, was markedly reduced compared with the glomeruli of control rats.
4	17699555	Patch-clamp experiments showed that ANG II-stimulated membrane currents in MCs were significantly attenuated or enhanced by knockdown or overexpression of TRPC6, respectively.
5	17699555	Fura-2 fluorescence measurements revealed that the ANG II-induced Ca(2+) influxes were markedly inhibited in MCs with TRPC6 knockdown, reminiscent of the impaired Ca(2+) entry in response to ANG II in high glucose-treated MCs.
6	18787184	Involvement of native TRPC3 proteins in ATP-dependent expression of VCAM-1 and monocyte adherence in coronary artery endothelial cells.
7	19098369	TRPV1 regulates adipogenesis and inflammation in adipose tissues, whereas TRPC3, TRPC5, TRPC6, TRPV1, and TRPM7 are involved in vasoconstriction and regulation of blood pressure.
8	19447651	Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus.
9	19447651	Expression of TRPC1, 3 and 6, STIM1 and Orai1 was analyzed by Western blotting in DM2 patients and controls.
10	19447651	We have found that expression of TRPC3, Orai1 and STIM1 is enhanced in DM2 subjects as compared to controls.
11	19447651	Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus.
12	19447651	Expression of TRPC1, 3 and 6, STIM1 and Orai1 was analyzed by Western blotting in DM2 patients and controls.
13	19447651	We have found that expression of TRPC3, Orai1 and STIM1 is enhanced in DM2 subjects as compared to controls.
14	20337661	Expression of TRPC1, TRPC3 and TRPC6 mRNA and protein was found in Wistar rats.
15	20337661	The expression of TRPC1 and TRPC6, but not TRPC3, was increased approximately twofold in GK rats compared with Wistar rats. 5.
16	20337661	Expression of TRPC1, TRPC3 and TRPC6 mRNA and protein was found in Wistar rats.
17	20337661	The expression of TRPC1 and TRPC6, but not TRPC3, was increased approximately twofold in GK rats compared with Wistar rats. 5.
18	21290315	The TRPC members TRPC3 and TRPC4 can serve as subunits of a redox-sensitive ion channel in native aortic endothelial cells.
19	21290315	The TRPM family member TRPM2 has a number of physiologic isoforms expressed in many cell types and responds to stimuli including oxidative stress, TNFα, and β-amyloid peptide.
20	21290315	The important role of TRPM2 isoforms in cell proliferation and oxidant-induced cell death has been well established using divergent cell systems and techniques including overexpression, channel depletion or inhibition, and calcium chelation.
21	21684255	We have recently shown that in macrophages proper operation of the survival pathways phosphatidylinositol-3-kinase (PI3K)/AKT and nuclear factor kappa B (NFkB) has an obligatory requirement for constitutive, non-regulated Ca(2+) influx.
22	21684255	Treatment of TRPC3(+/+) macrophages with the pro-apoptotic cytokine TNFα induced time-dependent phosphorylation of IκBα, AKT and BAD, and this was drastically reduced in TRPC3(-/-) macrophages.