- About
- Home
- Introduction
- Statistics
- Programs
- Dignet
- Gene
- GenePair
- BioSummarAI
- Help & Docs
- Documents
- Help
- FAQs
- Links
- Acknowledge
- Disclaimer
- Contact Us
Gene Information
Gene symbol: TRPC4
Gene name: transient receptor potential cation channel, subfamily C, member 4
HGNC ID: 12336
Synonyms: HTRP4, TRP4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | LEP | 1 hits |
| 2 | PRKAA1 | 1 hits |
| 3 | TRPC3 | 1 hits |
| 4 | TRPV4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17434294 | Evidence suggests that dysregulation of TRPC4 and -C1 results in vascular endothelial barrier dysfunction; malfunction of TRPP1 and -P2 impairs endothelial NO synthase; the reduced expression or activity of TRPC4 and -V1 impairs agonist-induced vascular relaxation; the decreased activity of TRPV4 reduces flow-induced vascular responses; and the activity of TRPC3 and -C4 is associated with oxidative stress-induced endothelial damage. |
| 2 | 21290315 | The TRPC members TRPC3 and TRPC4 can serve as subunits of a redox-sensitive ion channel in native aortic endothelial cells. |
| 3 | 21290315 | The TRPM family member TRPM2 has a number of physiologic isoforms expressed in many cell types and responds to stimuli including oxidative stress, TNFα, and β-amyloid peptide. |
| 4 | 21290315 | The important role of TRPM2 isoforms in cell proliferation and oxidant-induced cell death has been well established using divergent cell systems and techniques including overexpression, channel depletion or inhibition, and calcium chelation. |
| 5 | 23858470 | Leptin promotes K(ATP) channel trafficking by AMPK signaling in pancreatic β-cells. |
| 6 | 23858470 | In this study, we provide evidence that leptin modulates pancreatic β-cell functions by promoting K(ATP) channel translocation to the plasma membrane via AMP-activated protein kinase (AMPK) signaling. |
| 7 | 23858470 | We discovered that the molecular mechanism of leptin-induced AMPK activation involves canonical transient receptor potential 4 and calcium/calmodulin-dependent protein kinase kinase β. |
| 8 | 23858470 | AMPK activation was dependent on both leptin and glucose concentrations, so at optimal concentrations of leptin, AMPK was activated sufficiently to induce K(ATP) channel trafficking and hyperpolarization of pancreatic β-cells in a physiological range of fasting glucose levels. |