Ignet

Gene Information

Gene symbol: TRPM2

Gene name: transient receptor potential cation channel, subfamily M, member 2

HGNC ID: 12339

Synonyms: KNP3, LTRPC2, NUDT9L1, NUDT9H, EREG1

Related Genes

#	Gene Symbol	Number of hits
1	CLU	1 hits
2	INS	1 hits
3	PARP1	1 hits
4	PPA1	1 hits
5	TRPM3	1 hits
6	TRPM4	1 hits
7	TRPM5	1 hits
8	TRPM7	1 hits
9	TRPV1	1 hits
10	TRPV2	1 hits
11	TRPV4	1 hits

Related Sentences

#	PMID	Sentence
1	15952035	TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose.
2	15952035	A unique functional property within the transient receptor potential (TRP) family of cation channels is the gating of TRP (melastatin) 2 (TRPM2) channels by ADP-ribose (ADPR).
3	15952035	ADPR binds to the intracellular C-terminal tail of TRPM2, a domain that shows homology to enzymes with pyrophosphatase activity.
4	15952035	Cytosolic Ca(2+) enhances TRPM2 gating by ADPR; ADPR and Ca(2+) in concert may be an important messenger system mediating Ca(2+) influx.
5	15952035	Other stimuli of TRPM2 include NAD and H(2)O(2) and cyclic ADPR, which may act synergistically with ADPR.
6	15952035	In this review, we summarize the gating properties of TRPM2 and the proposed pathways of channel activation in vivo.
7	15952035	TRPM2 is likely to be a key player in several signalling pathways, mediating cell death in response to oxidative stress or in reperfusion injury.
8	15952035	TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose.
9	15952035	A unique functional property within the transient receptor potential (TRP) family of cation channels is the gating of TRP (melastatin) 2 (TRPM2) channels by ADP-ribose (ADPR).
10	15952035	ADPR binds to the intracellular C-terminal tail of TRPM2, a domain that shows homology to enzymes with pyrophosphatase activity.
11	15952035	Cytosolic Ca(2+) enhances TRPM2 gating by ADPR; ADPR and Ca(2+) in concert may be an important messenger system mediating Ca(2+) influx.
12	15952035	Other stimuli of TRPM2 include NAD and H(2)O(2) and cyclic ADPR, which may act synergistically with ADPR.
13	15952035	In this review, we summarize the gating properties of TRPM2 and the proposed pathways of channel activation in vivo.
14	15952035	TRPM2 is likely to be a key player in several signalling pathways, mediating cell death in response to oxidative stress or in reperfusion injury.
15	15952035	TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose.
16	15952035	A unique functional property within the transient receptor potential (TRP) family of cation channels is the gating of TRP (melastatin) 2 (TRPM2) channels by ADP-ribose (ADPR).
17	15952035	ADPR binds to the intracellular C-terminal tail of TRPM2, a domain that shows homology to enzymes with pyrophosphatase activity.
18	15952035	Cytosolic Ca(2+) enhances TRPM2 gating by ADPR; ADPR and Ca(2+) in concert may be an important messenger system mediating Ca(2+) influx.
19	15952035	Other stimuli of TRPM2 include NAD and H(2)O(2) and cyclic ADPR, which may act synergistically with ADPR.
20	15952035	In this review, we summarize the gating properties of TRPM2 and the proposed pathways of channel activation in vivo.
21	15952035	TRPM2 is likely to be a key player in several signalling pathways, mediating cell death in response to oxidative stress or in reperfusion injury.
22	15952035	TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose.
23	15952035	A unique functional property within the transient receptor potential (TRP) family of cation channels is the gating of TRP (melastatin) 2 (TRPM2) channels by ADP-ribose (ADPR).
24	15952035	ADPR binds to the intracellular C-terminal tail of TRPM2, a domain that shows homology to enzymes with pyrophosphatase activity.
25	15952035	Cytosolic Ca(2+) enhances TRPM2 gating by ADPR; ADPR and Ca(2+) in concert may be an important messenger system mediating Ca(2+) influx.
26	15952035	Other stimuli of TRPM2 include NAD and H(2)O(2) and cyclic ADPR, which may act synergistically with ADPR.
27	15952035	In this review, we summarize the gating properties of TRPM2 and the proposed pathways of channel activation in vivo.
28	15952035	TRPM2 is likely to be a key player in several signalling pathways, mediating cell death in response to oxidative stress or in reperfusion injury.
29	15952035	TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose.
30	15952035	A unique functional property within the transient receptor potential (TRP) family of cation channels is the gating of TRP (melastatin) 2 (TRPM2) channels by ADP-ribose (ADPR).
31	15952035	ADPR binds to the intracellular C-terminal tail of TRPM2, a domain that shows homology to enzymes with pyrophosphatase activity.
32	15952035	Cytosolic Ca(2+) enhances TRPM2 gating by ADPR; ADPR and Ca(2+) in concert may be an important messenger system mediating Ca(2+) influx.
33	15952035	Other stimuli of TRPM2 include NAD and H(2)O(2) and cyclic ADPR, which may act synergistically with ADPR.
34	15952035	In this review, we summarize the gating properties of TRPM2 and the proposed pathways of channel activation in vivo.
35	15952035	TRPM2 is likely to be a key player in several signalling pathways, mediating cell death in response to oxidative stress or in reperfusion injury.
36	15952035	TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose.
37	15952035	A unique functional property within the transient receptor potential (TRP) family of cation channels is the gating of TRP (melastatin) 2 (TRPM2) channels by ADP-ribose (ADPR).
38	15952035	ADPR binds to the intracellular C-terminal tail of TRPM2, a domain that shows homology to enzymes with pyrophosphatase activity.
39	15952035	Cytosolic Ca(2+) enhances TRPM2 gating by ADPR; ADPR and Ca(2+) in concert may be an important messenger system mediating Ca(2+) influx.
40	15952035	Other stimuli of TRPM2 include NAD and H(2)O(2) and cyclic ADPR, which may act synergistically with ADPR.
41	15952035	In this review, we summarize the gating properties of TRPM2 and the proposed pathways of channel activation in vivo.
42	15952035	TRPM2 is likely to be a key player in several signalling pathways, mediating cell death in response to oxidative stress or in reperfusion injury.
43	15952035	TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose.
44	15952035	A unique functional property within the transient receptor potential (TRP) family of cation channels is the gating of TRP (melastatin) 2 (TRPM2) channels by ADP-ribose (ADPR).
45	15952035	ADPR binds to the intracellular C-terminal tail of TRPM2, a domain that shows homology to enzymes with pyrophosphatase activity.
46	15952035	Cytosolic Ca(2+) enhances TRPM2 gating by ADPR; ADPR and Ca(2+) in concert may be an important messenger system mediating Ca(2+) influx.
47	15952035	Other stimuli of TRPM2 include NAD and H(2)O(2) and cyclic ADPR, which may act synergistically with ADPR.
48	15952035	In this review, we summarize the gating properties of TRPM2 and the proposed pathways of channel activation in vivo.
49	15952035	TRPM2 is likely to be a key player in several signalling pathways, mediating cell death in response to oxidative stress or in reperfusion injury.
50	16025303	To date, two TRPM family members, TRPM2 and TRPM7, have been implicated directly as central components of cell death pathways.
51	16025303	TRPM2, a Ca(2+)-permeant, non-selective cation channel, senses and responds to oxidative stress levels in the cell.
52	16025303	To date, two TRPM family members, TRPM2 and TRPM7, have been implicated directly as central components of cell death pathways.
53	16025303	TRPM2, a Ca(2+)-permeant, non-selective cation channel, senses and responds to oxidative stress levels in the cell.
54	17217061	TRPM2 is a cation channel enabling influx of Na+ and Ca2+, leading to depolarization and increases in the cytosolic Ca2+ concentration ([Ca2+]i).
55	17217061	Endogenous ADPR concentrations in leucocytes are sufficiently high to activate TRPM2 in the presence of an increased [Ca2+]i but probably not at resting [Ca2+]i.
56	17217061	H2O2-stimulated TRPM2 channels essentially contribute to insulin secretion in pancreatic beta-cells and alloxan-induced diabetes mellitus.
57	17217061	Inhibition of TRPM2 channels may be achieved by channel blockers such as flufenamic acid or the anti-fungal agents clotrimazole or econazole.
58	17217061	Selective blockers of TRPM2 are not yet available; those would be valuable for a characterization of biological roles of TRPM2 in various tissues and as potential drugs directed against oxidative cell damage, reperfusion injury or leucocyte activation.
59	17217061	Activation of TRPM2 may be prevented by anti-oxidants, PARP inhibitors and glycohydrolase inhibitors.
60	17217061	In light of the wide-spread expression and growing list of cellular functions of TRPM2, useful therapeutic applications are expected for future drugs that block TRPM2 channels or inhibit their activation.
61	17217061	TRPM2 is a cation channel enabling influx of Na+ and Ca2+, leading to depolarization and increases in the cytosolic Ca2+ concentration ([Ca2+]i).
62	17217061	Endogenous ADPR concentrations in leucocytes are sufficiently high to activate TRPM2 in the presence of an increased [Ca2+]i but probably not at resting [Ca2+]i.
63	17217061	H2O2-stimulated TRPM2 channels essentially contribute to insulin secretion in pancreatic beta-cells and alloxan-induced diabetes mellitus.
64	17217061	Inhibition of TRPM2 channels may be achieved by channel blockers such as flufenamic acid or the anti-fungal agents clotrimazole or econazole.
65	17217061	Selective blockers of TRPM2 are not yet available; those would be valuable for a characterization of biological roles of TRPM2 in various tissues and as potential drugs directed against oxidative cell damage, reperfusion injury or leucocyte activation.
66	17217061	Activation of TRPM2 may be prevented by anti-oxidants, PARP inhibitors and glycohydrolase inhibitors.
67	17217061	In light of the wide-spread expression and growing list of cellular functions of TRPM2, useful therapeutic applications are expected for future drugs that block TRPM2 channels or inhibit their activation.
68	17217061	TRPM2 is a cation channel enabling influx of Na+ and Ca2+, leading to depolarization and increases in the cytosolic Ca2+ concentration ([Ca2+]i).
69	17217061	Endogenous ADPR concentrations in leucocytes are sufficiently high to activate TRPM2 in the presence of an increased [Ca2+]i but probably not at resting [Ca2+]i.
70	17217061	H2O2-stimulated TRPM2 channels essentially contribute to insulin secretion in pancreatic beta-cells and alloxan-induced diabetes mellitus.
71	17217061	Inhibition of TRPM2 channels may be achieved by channel blockers such as flufenamic acid or the anti-fungal agents clotrimazole or econazole.
72	17217061	Selective blockers of TRPM2 are not yet available; those would be valuable for a characterization of biological roles of TRPM2 in various tissues and as potential drugs directed against oxidative cell damage, reperfusion injury or leucocyte activation.
73	17217061	Activation of TRPM2 may be prevented by anti-oxidants, PARP inhibitors and glycohydrolase inhibitors.
74	17217061	In light of the wide-spread expression and growing list of cellular functions of TRPM2, useful therapeutic applications are expected for future drugs that block TRPM2 channels or inhibit their activation.
75	17217061	TRPM2 is a cation channel enabling influx of Na+ and Ca2+, leading to depolarization and increases in the cytosolic Ca2+ concentration ([Ca2+]i).
76	17217061	Endogenous ADPR concentrations in leucocytes are sufficiently high to activate TRPM2 in the presence of an increased [Ca2+]i but probably not at resting [Ca2+]i.
77	17217061	H2O2-stimulated TRPM2 channels essentially contribute to insulin secretion in pancreatic beta-cells and alloxan-induced diabetes mellitus.
78	17217061	Inhibition of TRPM2 channels may be achieved by channel blockers such as flufenamic acid or the anti-fungal agents clotrimazole or econazole.
79	17217061	Selective blockers of TRPM2 are not yet available; those would be valuable for a characterization of biological roles of TRPM2 in various tissues and as potential drugs directed against oxidative cell damage, reperfusion injury or leucocyte activation.
80	17217061	Activation of TRPM2 may be prevented by anti-oxidants, PARP inhibitors and glycohydrolase inhibitors.
81	17217061	In light of the wide-spread expression and growing list of cellular functions of TRPM2, useful therapeutic applications are expected for future drugs that block TRPM2 channels or inhibit their activation.
82	17217061	TRPM2 is a cation channel enabling influx of Na+ and Ca2+, leading to depolarization and increases in the cytosolic Ca2+ concentration ([Ca2+]i).
83	17217061	Endogenous ADPR concentrations in leucocytes are sufficiently high to activate TRPM2 in the presence of an increased [Ca2+]i but probably not at resting [Ca2+]i.
84	17217061	H2O2-stimulated TRPM2 channels essentially contribute to insulin secretion in pancreatic beta-cells and alloxan-induced diabetes mellitus.
85	17217061	Inhibition of TRPM2 channels may be achieved by channel blockers such as flufenamic acid or the anti-fungal agents clotrimazole or econazole.
86	17217061	Selective blockers of TRPM2 are not yet available; those would be valuable for a characterization of biological roles of TRPM2 in various tissues and as potential drugs directed against oxidative cell damage, reperfusion injury or leucocyte activation.
87	17217061	Activation of TRPM2 may be prevented by anti-oxidants, PARP inhibitors and glycohydrolase inhibitors.
88	17217061	In light of the wide-spread expression and growing list of cellular functions of TRPM2, useful therapeutic applications are expected for future drugs that block TRPM2 channels or inhibit their activation.
89	17217061	TRPM2 is a cation channel enabling influx of Na+ and Ca2+, leading to depolarization and increases in the cytosolic Ca2+ concentration ([Ca2+]i).
90	17217061	Endogenous ADPR concentrations in leucocytes are sufficiently high to activate TRPM2 in the presence of an increased [Ca2+]i but probably not at resting [Ca2+]i.
91	17217061	H2O2-stimulated TRPM2 channels essentially contribute to insulin secretion in pancreatic beta-cells and alloxan-induced diabetes mellitus.
92	17217061	Inhibition of TRPM2 channels may be achieved by channel blockers such as flufenamic acid or the anti-fungal agents clotrimazole or econazole.
93	17217061	Selective blockers of TRPM2 are not yet available; those would be valuable for a characterization of biological roles of TRPM2 in various tissues and as potential drugs directed against oxidative cell damage, reperfusion injury or leucocyte activation.
94	17217061	Activation of TRPM2 may be prevented by anti-oxidants, PARP inhibitors and glycohydrolase inhibitors.
95	17217061	In light of the wide-spread expression and growing list of cellular functions of TRPM2, useful therapeutic applications are expected for future drugs that block TRPM2 channels or inhibit their activation.
96	17217061	TRPM2 is a cation channel enabling influx of Na+ and Ca2+, leading to depolarization and increases in the cytosolic Ca2+ concentration ([Ca2+]i).
97	17217061	Endogenous ADPR concentrations in leucocytes are sufficiently high to activate TRPM2 in the presence of an increased [Ca2+]i but probably not at resting [Ca2+]i.
98	17217061	H2O2-stimulated TRPM2 channels essentially contribute to insulin secretion in pancreatic beta-cells and alloxan-induced diabetes mellitus.
99	17217061	Inhibition of TRPM2 channels may be achieved by channel blockers such as flufenamic acid or the anti-fungal agents clotrimazole or econazole.
100	17217061	Selective blockers of TRPM2 are not yet available; those would be valuable for a characterization of biological roles of TRPM2 in various tissues and as potential drugs directed against oxidative cell damage, reperfusion injury or leucocyte activation.
101	17217061	Activation of TRPM2 may be prevented by anti-oxidants, PARP inhibitors and glycohydrolase inhibitors.
102	17217061	In light of the wide-spread expression and growing list of cellular functions of TRPM2, useful therapeutic applications are expected for future drugs that block TRPM2 channels or inhibit their activation.
103	21135052	TRPM2: a multifunctional ion channel for calcium signalling.
104	21135052	The transient potential receptor melastatin-2 (TRPM2) channel has emerged as an important Ca(2+) signalling mechanism in a variety of cells, contributing to cellular functions that include cytokine production, insulin release, cell motility and cell death.
105	21135052	Its ability to respond to reactive oxygen species has made TRPM2 a potential therapeutic target for chronic inflammation, neurodegenerative diseases, and oxidative stress-related pathologies.
106	21135052	TRPM2 is a non-selective, calcium (Ca(2+))-permeable cation channel of the melastatin-related transient receptor potential (TRPM) ion channel subfamily.
107	21135052	In addition to its role mediating Ca(2+) influx into the cells, TRPM2 can also function as a lysosomal Ca(2+) release channel, contributing to cell death.
108	21135052	The physiological and pathophysiological context of ROS-mediated events makes TRPM2 a promising target for the development of therapeutic tools of inflammatory and degenerative diseases.
109	21135052	TRPM2: a multifunctional ion channel for calcium signalling.
110	21135052	The transient potential receptor melastatin-2 (TRPM2) channel has emerged as an important Ca(2+) signalling mechanism in a variety of cells, contributing to cellular functions that include cytokine production, insulin release, cell motility and cell death.
111	21135052	Its ability to respond to reactive oxygen species has made TRPM2 a potential therapeutic target for chronic inflammation, neurodegenerative diseases, and oxidative stress-related pathologies.
112	21135052	TRPM2 is a non-selective, calcium (Ca(2+))-permeable cation channel of the melastatin-related transient receptor potential (TRPM) ion channel subfamily.
113	21135052	In addition to its role mediating Ca(2+) influx into the cells, TRPM2 can also function as a lysosomal Ca(2+) release channel, contributing to cell death.
114	21135052	The physiological and pathophysiological context of ROS-mediated events makes TRPM2 a promising target for the development of therapeutic tools of inflammatory and degenerative diseases.
115	21135052	TRPM2: a multifunctional ion channel for calcium signalling.
116	21135052	The transient potential receptor melastatin-2 (TRPM2) channel has emerged as an important Ca(2+) signalling mechanism in a variety of cells, contributing to cellular functions that include cytokine production, insulin release, cell motility and cell death.
117	21135052	Its ability to respond to reactive oxygen species has made TRPM2 a potential therapeutic target for chronic inflammation, neurodegenerative diseases, and oxidative stress-related pathologies.
118	21135052	TRPM2 is a non-selective, calcium (Ca(2+))-permeable cation channel of the melastatin-related transient receptor potential (TRPM) ion channel subfamily.
119	21135052	In addition to its role mediating Ca(2+) influx into the cells, TRPM2 can also function as a lysosomal Ca(2+) release channel, contributing to cell death.
120	21135052	The physiological and pathophysiological context of ROS-mediated events makes TRPM2 a promising target for the development of therapeutic tools of inflammatory and degenerative diseases.
121	21135052	TRPM2: a multifunctional ion channel for calcium signalling.
122	21135052	The transient potential receptor melastatin-2 (TRPM2) channel has emerged as an important Ca(2+) signalling mechanism in a variety of cells, contributing to cellular functions that include cytokine production, insulin release, cell motility and cell death.
123	21135052	Its ability to respond to reactive oxygen species has made TRPM2 a potential therapeutic target for chronic inflammation, neurodegenerative diseases, and oxidative stress-related pathologies.
124	21135052	TRPM2 is a non-selective, calcium (Ca(2+))-permeable cation channel of the melastatin-related transient receptor potential (TRPM) ion channel subfamily.
125	21135052	In addition to its role mediating Ca(2+) influx into the cells, TRPM2 can also function as a lysosomal Ca(2+) release channel, contributing to cell death.
126	21135052	The physiological and pathophysiological context of ROS-mediated events makes TRPM2 a promising target for the development of therapeutic tools of inflammatory and degenerative diseases.
127	21135052	TRPM2: a multifunctional ion channel for calcium signalling.
128	21135052	The transient potential receptor melastatin-2 (TRPM2) channel has emerged as an important Ca(2+) signalling mechanism in a variety of cells, contributing to cellular functions that include cytokine production, insulin release, cell motility and cell death.
129	21135052	Its ability to respond to reactive oxygen species has made TRPM2 a potential therapeutic target for chronic inflammation, neurodegenerative diseases, and oxidative stress-related pathologies.
130	21135052	TRPM2 is a non-selective, calcium (Ca(2+))-permeable cation channel of the melastatin-related transient receptor potential (TRPM) ion channel subfamily.
131	21135052	In addition to its role mediating Ca(2+) influx into the cells, TRPM2 can also function as a lysosomal Ca(2+) release channel, contributing to cell death.
132	21135052	The physiological and pathophysiological context of ROS-mediated events makes TRPM2 a promising target for the development of therapeutic tools of inflammatory and degenerative diseases.
133	21135052	TRPM2: a multifunctional ion channel for calcium signalling.
134	21135052	The transient potential receptor melastatin-2 (TRPM2) channel has emerged as an important Ca(2+) signalling mechanism in a variety of cells, contributing to cellular functions that include cytokine production, insulin release, cell motility and cell death.
135	21135052	Its ability to respond to reactive oxygen species has made TRPM2 a potential therapeutic target for chronic inflammation, neurodegenerative diseases, and oxidative stress-related pathologies.
136	21135052	TRPM2 is a non-selective, calcium (Ca(2+))-permeable cation channel of the melastatin-related transient receptor potential (TRPM) ion channel subfamily.
137	21135052	In addition to its role mediating Ca(2+) influx into the cells, TRPM2 can also function as a lysosomal Ca(2+) release channel, contributing to cell death.
138	21135052	The physiological and pathophysiological context of ROS-mediated events makes TRPM2 a promising target for the development of therapeutic tools of inflammatory and degenerative diseases.
139	21290315	The TRPC members TRPC3 and TRPC4 can serve as subunits of a redox-sensitive ion channel in native aortic endothelial cells.
140	21290315	The TRPM family member TRPM2 has a number of physiologic isoforms expressed in many cell types and responds to stimuli including oxidative stress, TNFα, and β-amyloid peptide.
141	21290315	The important role of TRPM2 isoforms in cell proliferation and oxidant-induced cell death has been well established using divergent cell systems and techniques including overexpression, channel depletion or inhibition, and calcium chelation.
142	21290315	The TRPC members TRPC3 and TRPC4 can serve as subunits of a redox-sensitive ion channel in native aortic endothelial cells.
143	21290315	The TRPM family member TRPM2 has a number of physiologic isoforms expressed in many cell types and responds to stimuli including oxidative stress, TNFα, and β-amyloid peptide.
144	21290315	The important role of TRPM2 isoforms in cell proliferation and oxidant-induced cell death has been well established using divergent cell systems and techniques including overexpression, channel depletion or inhibition, and calcium chelation.
145	21744203	Knock out models of TRPM2 and TRPM5, which show a pre-diabetic phenotype, will be illustrative for this purpose.
146	21744203	In addition, an unexpected role of the TRP channel TRPM3 as a gatekeeper of zinc, which is required for insulin storage, will be considered.
147	21785227	Interestingly, six of them (TRPM2, TRPM4, TRPM5, TRPV1, TRPV2 and TRPV4) are thermosensitive TRP channels.
148	21785227	TRPM channels (TRPM2, TRPM4 and TRPM5) control insulin secretion levels by sensing intracellular Ca2+ increase, NAD metabolites, or hormone receptor activation.
149	21785227	TRPV2 is involved not only in insulin secretion but also cell proliferation, and is regulated by the autocrine effects of insulin.
150	21785227	Interestingly, six of them (TRPM2, TRPM4, TRPM5, TRPV1, TRPV2 and TRPV4) are thermosensitive TRP channels.
151	21785227	TRPM channels (TRPM2, TRPM4 and TRPM5) control insulin secretion levels by sensing intracellular Ca2+ increase, NAD metabolites, or hormone receptor activation.
152	21785227	TRPV2 is involved not only in insulin secretion but also cell proliferation, and is regulated by the autocrine effects of insulin.
153	22750002	Divalent copper is a potent extracellular blocker for TRPM2 channel.
154	22750002	Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cationic channel in the TRP channel family.
155	22750002	However, little is known about the effect of redox-active metal ions, such as copper, on TRPM2 channels.
156	22750002	TRPM2 channel was over-expressed in HEK-293 cells and the whole-cell current was recorded by patch clamp.
157	22750002	TRPM2 current was also blocked by Hg(2+), Pb(2+), Fe(2+) and Se(2+).
158	22750002	We concluded that Cu(2+) is a potent TRPM2 channel blocker.
159	22750002	The sensitivity of TRPM2 channel to heavy metal ions could be a new mechanism for the pathogenesis of some metal ion-related diseases.
160	22750002	Divalent copper is a potent extracellular blocker for TRPM2 channel.
161	22750002	Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cationic channel in the TRP channel family.
162	22750002	However, little is known about the effect of redox-active metal ions, such as copper, on TRPM2 channels.
163	22750002	TRPM2 channel was over-expressed in HEK-293 cells and the whole-cell current was recorded by patch clamp.
164	22750002	TRPM2 current was also blocked by Hg(2+), Pb(2+), Fe(2+) and Se(2+).
165	22750002	We concluded that Cu(2+) is a potent TRPM2 channel blocker.
166	22750002	The sensitivity of TRPM2 channel to heavy metal ions could be a new mechanism for the pathogenesis of some metal ion-related diseases.
167	22750002	Divalent copper is a potent extracellular blocker for TRPM2 channel.
168	22750002	Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cationic channel in the TRP channel family.
169	22750002	However, little is known about the effect of redox-active metal ions, such as copper, on TRPM2 channels.
170	22750002	TRPM2 channel was over-expressed in HEK-293 cells and the whole-cell current was recorded by patch clamp.
171	22750002	TRPM2 current was also blocked by Hg(2+), Pb(2+), Fe(2+) and Se(2+).
172	22750002	We concluded that Cu(2+) is a potent TRPM2 channel blocker.
173	22750002	The sensitivity of TRPM2 channel to heavy metal ions could be a new mechanism for the pathogenesis of some metal ion-related diseases.
174	22750002	Divalent copper is a potent extracellular blocker for TRPM2 channel.
175	22750002	Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cationic channel in the TRP channel family.
176	22750002	However, little is known about the effect of redox-active metal ions, such as copper, on TRPM2 channels.
177	22750002	TRPM2 channel was over-expressed in HEK-293 cells and the whole-cell current was recorded by patch clamp.
178	22750002	TRPM2 current was also blocked by Hg(2+), Pb(2+), Fe(2+) and Se(2+).
179	22750002	We concluded that Cu(2+) is a potent TRPM2 channel blocker.
180	22750002	The sensitivity of TRPM2 channel to heavy metal ions could be a new mechanism for the pathogenesis of some metal ion-related diseases.
181	22750002	Divalent copper is a potent extracellular blocker for TRPM2 channel.
182	22750002	Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cationic channel in the TRP channel family.
183	22750002	However, little is known about the effect of redox-active metal ions, such as copper, on TRPM2 channels.
184	22750002	TRPM2 channel was over-expressed in HEK-293 cells and the whole-cell current was recorded by patch clamp.
185	22750002	TRPM2 current was also blocked by Hg(2+), Pb(2+), Fe(2+) and Se(2+).
186	22750002	We concluded that Cu(2+) is a potent TRPM2 channel blocker.
187	22750002	The sensitivity of TRPM2 channel to heavy metal ions could be a new mechanism for the pathogenesis of some metal ion-related diseases.
188	22750002	Divalent copper is a potent extracellular blocker for TRPM2 channel.
189	22750002	Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cationic channel in the TRP channel family.
190	22750002	However, little is known about the effect of redox-active metal ions, such as copper, on TRPM2 channels.
191	22750002	TRPM2 channel was over-expressed in HEK-293 cells and the whole-cell current was recorded by patch clamp.
192	22750002	TRPM2 current was also blocked by Hg(2+), Pb(2+), Fe(2+) and Se(2+).
193	22750002	We concluded that Cu(2+) is a potent TRPM2 channel blocker.
194	22750002	The sensitivity of TRPM2 channel to heavy metal ions could be a new mechanism for the pathogenesis of some metal ion-related diseases.
195	22750002	Divalent copper is a potent extracellular blocker for TRPM2 channel.
196	22750002	Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cationic channel in the TRP channel family.
197	22750002	However, little is known about the effect of redox-active metal ions, such as copper, on TRPM2 channels.
198	22750002	TRPM2 channel was over-expressed in HEK-293 cells and the whole-cell current was recorded by patch clamp.
199	22750002	TRPM2 current was also blocked by Hg(2+), Pb(2+), Fe(2+) and Se(2+).
200	22750002	We concluded that Cu(2+) is a potent TRPM2 channel blocker.
201	22750002	The sensitivity of TRPM2 channel to heavy metal ions could be a new mechanism for the pathogenesis of some metal ion-related diseases.