Ignet

Gene Information

Gene symbol: TRPM3

Gene name: transient receptor potential cation channel, subfamily M, member 3

HGNC ID: 17992

Synonyms: KIAA1616, LTRPC3, GON-2

Related Genes

#	Gene Symbol	Number of hits
1	CLU	1 hits
2	INS	1 hits
3	TRPM2	1 hits

Related Sentences

#	PMID	Sentence
1	15952035	TRPM2: a calcium influx pathway regulated by oxidative stress and the novel second messenger ADP-ribose.
2	15952035	A unique functional property within the transient receptor potential (TRP) family of cation channels is the gating of TRP (melastatin) 2 (TRPM2) channels by ADP-ribose (ADPR).
3	15952035	ADPR binds to the intracellular C-terminal tail of TRPM2, a domain that shows homology to enzymes with pyrophosphatase activity.
4	15952035	Cytosolic Ca(2+) enhances TRPM2 gating by ADPR; ADPR and Ca(2+) in concert may be an important messenger system mediating Ca(2+) influx.
5	15952035	Other stimuli of TRPM2 include NAD and H(2)O(2) and cyclic ADPR, which may act synergistically with ADPR.
6	15952035	In this review, we summarize the gating properties of TRPM2 and the proposed pathways of channel activation in vivo.
7	15952035	TRPM2 is likely to be a key player in several signalling pathways, mediating cell death in response to oxidative stress or in reperfusion injury.
8	21135052	TRPM2: a multifunctional ion channel for calcium signalling.
9	21135052	The transient potential receptor melastatin-2 (TRPM2) channel has emerged as an important Ca(2+) signalling mechanism in a variety of cells, contributing to cellular functions that include cytokine production, insulin release, cell motility and cell death.
10	21135052	Its ability to respond to reactive oxygen species has made TRPM2 a potential therapeutic target for chronic inflammation, neurodegenerative diseases, and oxidative stress-related pathologies.
11	21135052	TRPM2 is a non-selective, calcium (Ca(2+))-permeable cation channel of the melastatin-related transient receptor potential (TRPM) ion channel subfamily.
12	21135052	In addition to its role mediating Ca(2+) influx into the cells, TRPM2 can also function as a lysosomal Ca(2+) release channel, contributing to cell death.
13	21135052	The physiological and pathophysiological context of ROS-mediated events makes TRPM2 a promising target for the development of therapeutic tools of inflammatory and degenerative diseases.
14	21744203	Knock out models of TRPM2 and TRPM5, which show a pre-diabetic phenotype, will be illustrative for this purpose.
15	21744203	In addition, an unexpected role of the TRP channel TRPM3 as a gatekeeper of zinc, which is required for insulin storage, will be considered.
16	22750002	Divalent copper is a potent extracellular blocker for TRPM2 channel.
17	22750002	Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable cationic channel in the TRP channel family.
18	22750002	However, little is known about the effect of redox-active metal ions, such as copper, on TRPM2 channels.
19	22750002	TRPM2 channel was over-expressed in HEK-293 cells and the whole-cell current was recorded by patch clamp.
20	22750002	TRPM2 current was also blocked by Hg(2+), Pb(2+), Fe(2+) and Se(2+).
21	22750002	We concluded that Cu(2+) is a potent TRPM2 channel blocker.
22	22750002	The sensitivity of TRPM2 channel to heavy metal ions could be a new mechanism for the pathogenesis of some metal ion-related diseases.