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Gene Information
Gene symbol: TWIST1
Gene name: twist basic helix-loop-helix transcription factor 1
HGNC ID: 12428
Synonyms: SCS, H-twist, BPES2, bHLHa38
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACCS | 1 hits |
| 2 | CKB | 1 hits |
| 3 | INS | 1 hits |
| 4 | ITK | 1 hits |
| 5 | SNAI2 | 1 hits |
| 6 | TGFB1 | 1 hits |
| 7 | TWIST2 | 1 hits |
| 8 | ZEB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14675574 | The incidence of any periprocedural creatinine kinase-MB elevation was 17.1% versus 18.9% (p=NS) and 30-day major adverse cardiac events (death, disabling stroke, creatine kinase-MB >3 times the upper limit of normal, urgent revascularization) was 5.9% versus 4.6% (p=NS) when comparing the ACS and SCS groups, respectively. |
| 2 | 21088486 | Transforming Growth Factor-b (TGFb) is a major driving force of the Epithelial-to-Mesenchymal (EMT) genetic program, which becomes overactive in the pathophysiology of many age-related human diseases. |
| 3 | 21088486 | TGFb-driven EMT is sufficient to generate migrating cancer stem cells by directly linking the acquisition of cellular motility with the maintenance of tumor-initiating (stemness) capacity. |
| 4 | 21088486 | Chronic diseases exhibiting excessive fibrosis can be caused by repeated and sustained infliction of TGFb-driven EMT, which increases collagen and extracellular matrix synthesis. |
| 5 | 21088486 | Pharmacological prevention and/or reversal of TGFb-induced EMT may therefore have important clinical applications in the management of cancer metastasis as well as in the prevention and/or treatment of end-state organ failures. |
| 6 | 21088486 | ZEB1, TWIST1, SNAIL2 [Slug], TGFbs), we recently hypothesized that prevention of TGFb-induced EMT might represent a common molecular mechanism underlying the anti-cancer stem cells and anti-fibrotic actions of metformin. |
| 7 | 21088486 | Remarkably, metformin exposure not only impedes TGFb-promoted loss of the epithelial marker E-cadherin in MCF-7 breast cancer cells but it prevents further TGF-induced cell scattering and accumulation of the mesenchymal marker vimentin in Madin-Darby canine kidney (MDCK) cells. |
| 8 | 22969750 | The Twist proteins (Twist-1 and -2) are highly conserved developmental proteins with key roles for the transcriptional regulation in mesenchymal cell lineages. |
| 9 | 22969750 | Moreover, Twist1 expression is strongly correlated with BMI and insulin resistance in humans. |
| 10 | 22969750 | The Twist proteins (Twist-1 and -2) are highly conserved developmental proteins with key roles for the transcriptional regulation in mesenchymal cell lineages. |
| 11 | 22969750 | Moreover, Twist1 expression is strongly correlated with BMI and insulin resistance in humans. |