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Gene Information
Gene symbol: TWIST2
Gene name: twist basic helix-loop-helix transcription factor 2
HGNC ID: 20670
Synonyms: DERMO1, Dermo-1, bHLHa39
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | RUNX2 | 1 hits |
| 2 | TWIST1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18162513 | Runt-related transcription factor 2 (RUNX2), and several RUNX2 target genes, including matrix metalloproteinase-9, Akp2, integrin binding sialoprotein, Dmp1, Col1a2, Phex, Vdr, osteocalcin, and osterix, were all significantly down-regulated in the insulin-deficient, hyperglycemic diabetic animals; however, insulin treatment of diabetic animals significantly restored their expression. |
| 2 | 18162513 | Expression of bone morphogenic protein-2, transcriptional coactivator with PDZ-binding motif, and TWIST2, all important regulators of RUNX2, were not impacted by the diabetic condition, suggesting that the defect in osteogenesis resides at the level of RUNX2 expression and its activity. |
| 3 | 22969750 | The Twist proteins (Twist-1 and -2) are highly conserved developmental proteins with key roles for the transcriptional regulation in mesenchymal cell lineages. |
| 4 | 22969750 | Moreover, Twist1 expression is strongly correlated with BMI and insulin resistance in humans. |