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Gene Information
Gene symbol: TYMS
Gene name: thymidylate synthetase
HGNC ID: 12441
Synonyms: Tsase, TMS, HsT422
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADH1A | 1 hits |
| 2 | AKR1A1 | 1 hits |
| 3 | CASP3 | 1 hits |
| 4 | GSR | 1 hits |
| 5 | TOP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7509872 | These RLAR inhibitors were found not to produce significant inhibition of genetically-linked reductases (aldehyde reductase, ALR), catalytically similar reductases (Pachysolen tannophilus xylose reductase, PTXR), functionally distinct oxidoreductases (glutathione reductase, GR, lactate dehydrogenase, LDH, and gamma-transaminase, GABA-T), and thymidylate synthase (TS). |
| 2 | 16010439 | Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms. |
| 3 | 16010439 | Both drugs also augmented the proteolytic cleavage of the Rho-kinase ROCK-1 that was attenuated by the caspase-3 pathway inhibitor z-DEVD-fmk. |