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PMID |
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22843503
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Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
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22843503
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Resistin is a polypeptide hormone that was reported to be associated with insulin resistance, inflammation and risk of type 2 diabetes and cardiovascular disease.
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22843503
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We confirmed the association with a previously known locus, the RETN gene (19p13.2), and identified two novel loci near the TYW3/CRYZ gene (1p31) and the NDST4 gene (4q25), associated with resistin levels at a genome-wide significant level, best represented by SNP rs3931020 (P = 6.37 × 10(-12)) and SNP rs13144478 (P = 6.19 × 10(-18)), respectively.
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22843503
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In addition, the resistin-rising allele of the TYW3/CRYZ SNP rs3931020, but not the NDST4 SNP rs13144478, showed a consistent association with increased coronary heart disease risk [odds ratio = 1.18 (95% CI, 1.03-1.34); P = 0.01].
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22843503
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Our results suggest that genetic variants in TYW3/CRYZ and NDST4 loci may be involved in the regulation of circulating resistin levels.
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22843503
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More studies are needed to verify the associations of the SNP rs13144478 with NDST4 gene expression and resistin-related disease.
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7 |
22843503
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Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
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8 |
22843503
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Resistin is a polypeptide hormone that was reported to be associated with insulin resistance, inflammation and risk of type 2 diabetes and cardiovascular disease.
|
9 |
22843503
|
We confirmed the association with a previously known locus, the RETN gene (19p13.2), and identified two novel loci near the TYW3/CRYZ gene (1p31) and the NDST4 gene (4q25), associated with resistin levels at a genome-wide significant level, best represented by SNP rs3931020 (P = 6.37 × 10(-12)) and SNP rs13144478 (P = 6.19 × 10(-18)), respectively.
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10 |
22843503
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In addition, the resistin-rising allele of the TYW3/CRYZ SNP rs3931020, but not the NDST4 SNP rs13144478, showed a consistent association with increased coronary heart disease risk [odds ratio = 1.18 (95% CI, 1.03-1.34); P = 0.01].
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11 |
22843503
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Our results suggest that genetic variants in TYW3/CRYZ and NDST4 loci may be involved in the regulation of circulating resistin levels.
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12 |
22843503
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More studies are needed to verify the associations of the SNP rs13144478 with NDST4 gene expression and resistin-related disease.
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13 |
22843503
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Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
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14 |
22843503
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Resistin is a polypeptide hormone that was reported to be associated with insulin resistance, inflammation and risk of type 2 diabetes and cardiovascular disease.
|
15 |
22843503
|
We confirmed the association with a previously known locus, the RETN gene (19p13.2), and identified two novel loci near the TYW3/CRYZ gene (1p31) and the NDST4 gene (4q25), associated with resistin levels at a genome-wide significant level, best represented by SNP rs3931020 (P = 6.37 × 10(-12)) and SNP rs13144478 (P = 6.19 × 10(-18)), respectively.
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16 |
22843503
|
In addition, the resistin-rising allele of the TYW3/CRYZ SNP rs3931020, but not the NDST4 SNP rs13144478, showed a consistent association with increased coronary heart disease risk [odds ratio = 1.18 (95% CI, 1.03-1.34); P = 0.01].
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17 |
22843503
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Our results suggest that genetic variants in TYW3/CRYZ and NDST4 loci may be involved in the regulation of circulating resistin levels.
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18 |
22843503
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More studies are needed to verify the associations of the SNP rs13144478 with NDST4 gene expression and resistin-related disease.
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19 |
22843503
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Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
|
20 |
22843503
|
Resistin is a polypeptide hormone that was reported to be associated with insulin resistance, inflammation and risk of type 2 diabetes and cardiovascular disease.
|
21 |
22843503
|
We confirmed the association with a previously known locus, the RETN gene (19p13.2), and identified two novel loci near the TYW3/CRYZ gene (1p31) and the NDST4 gene (4q25), associated with resistin levels at a genome-wide significant level, best represented by SNP rs3931020 (P = 6.37 × 10(-12)) and SNP rs13144478 (P = 6.19 × 10(-18)), respectively.
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22 |
22843503
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In addition, the resistin-rising allele of the TYW3/CRYZ SNP rs3931020, but not the NDST4 SNP rs13144478, showed a consistent association with increased coronary heart disease risk [odds ratio = 1.18 (95% CI, 1.03-1.34); P = 0.01].
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23 |
22843503
|
Our results suggest that genetic variants in TYW3/CRYZ and NDST4 loci may be involved in the regulation of circulating resistin levels.
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24 |
22843503
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More studies are needed to verify the associations of the SNP rs13144478 with NDST4 gene expression and resistin-related disease.
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