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Gene Information
Gene symbol: UBASH3A
Gene name: ubiquitin associated and SH3 domain containing A
HGNC ID: 12462
Synonyms: STS-2, TULA, CLIP4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BACH2 | 1 hits |
| 2 | CLEC16A | 1 hits |
| 3 | ERBB3 | 1 hits |
| 4 | PTPN2 | 1 hits |
| 5 | PTPN22 | 1 hits |
| 6 | PTPRU | 1 hits |
| 7 | SH2B3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19956107 | In addition to the support for previously identified loci (PTPN22/1p13; ERBB3/12q13; SH2B3/12q24; CLEC16A/16p13; UBASH3A/21q22), evidence supporting two new and distinct chromosome locations associated with T1D was observed: FHOD3/18q12 (rs2644261, P=5.9 x 10(-4)) and Xp22 (rs5979785, P=6.8 x 10(-3); http://www.T1DBase.org). |
| 2 | 19956107 | In contrast, the Xp22 SNP is located 30 kb centromeric of the functional candidate genes TLR8 and TLR7 genes. |
| 3 | 19956107 | Both TLR8 and TLR7 are functional candidate genes owing to their key roles as pathogen recognition receptors and, in the case of TLR7, overexpression has been associated directly with murine autoimmune disease. |
| 4 | 21829393 | Two loci passed a stringent genome-wide significance level (p<10(-10)): 1q23/FCRL3 with IA-2A and 9q34/ABO with PCA. |
| 5 | 21829393 | Eleven of 52 non-MHC T1D loci showed evidence of association with at least one autoantibody at a false discovery rate of 16%: 16p11/IL27-IA-2A, 2q24/IFIH1-IA-2A and PCA, 2q32/STAT4-TPOA, 10p15/IL2RA-GADA, 6q15/BACH2-TPOA, 21q22/UBASH3A-TPOA, 1p13/PTPN22-TPOA, 2q33/CTLA4-TPOA, 4q27/IL2/TPOA, 15q14/RASGRP1/TPOA, and 12q24/SH2B3-GADA and TPOA. |
| 6 | 21829393 | Analysis of the TPOA-associated loci in 2,477 cases with Graves' disease identified two new AITD loci (BACH2 and UBASH3A). |
| 7 | 23804260 | Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22. |
| 8 | 23804260 | Several PTPs, PTPN22, PTPN2, and UBASH3A, have been associated with risk of type 1 diabetes (T1D) by genome wide association studies. |
| 9 | 23804260 | In this review, we discuss the genetic and functional implications of two of these PTPs, PTPN22 and PTPN2, in the development of T1D. |