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Gene Information
Gene symbol: UBR5
Gene name: ubiquitin protein ligase E3 component n-recognin 5
HGNC ID: 16806
Synonyms: DD5, HYD, EDD, KIAA0896
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PARK2 | 1 hits |
| 2 | PCK1 | 1 hits |
| 3 | RNF123 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21726808 | Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. |
| 2 | 21726808 | Whereas most glycolytic steps are reversible, the reaction catalyzed by pyruvate kinase is irreversible, and the reverse reaction requires phosphoenolpyruvate carboxykinase (PEPCK1) to commit for gluconeogenesis. |
| 3 | 21726808 | PEPCK1 is acetylated by the P300 acetyltransferase, and this acetylation stimulates the interaction between PEPCK1 and UBR5, a HECT domain containing E3 ubiquitin ligase, therefore promoting PEPCK1 ubiquitinylation and degradation. |
| 4 | 21726808 | Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. |
| 5 | 21726808 | Whereas most glycolytic steps are reversible, the reaction catalyzed by pyruvate kinase is irreversible, and the reverse reaction requires phosphoenolpyruvate carboxykinase (PEPCK1) to commit for gluconeogenesis. |
| 6 | 21726808 | PEPCK1 is acetylated by the P300 acetyltransferase, and this acetylation stimulates the interaction between PEPCK1 and UBR5, a HECT domain containing E3 ubiquitin ligase, therefore promoting PEPCK1 ubiquitinylation and degradation. |