Ignet

Gene Information

Gene symbol: UCN

Gene name: urocortin

HGNC ID: 12516

Synonyms: UROC, UI

Related Genes

#	Gene Symbol	Number of hits
1	CRH	1 hits
2	CRHR1	1 hits
3	CRHR2	1 hits
4	EDN1	1 hits
5	INS	1 hits
6	MT-CO1	1 hits
7	MT-TS1	1 hits
8	NPY	1 hits
9	POMC	1 hits
10	UCN3	1 hits

Related Sentences

#	PMID	Sentence
1	11337097	Injection of insulin (10 U/kg, ip) 1 or 2 h before the (125)I-urocortin decreased the K(i).
2	12841938	Urocortin is a peptide recently identified, structurally related to corticotropin releasing factor (CRF).
3	12841938	In the arterial segments precontracted with endothelin-1, urocortin produced concentration-dependent relaxation, and the order of sensitivity was: tail > basilar > coronary.
4	12841938	Urocortin is a peptide recently identified, structurally related to corticotropin releasing factor (CRF).
5	12841938	In the arterial segments precontracted with endothelin-1, urocortin produced concentration-dependent relaxation, and the order of sensitivity was: tail > basilar > coronary.
6	14764822	We characterized the expression of CRH receptors 1 and 2 and CRH-like peptides stresscopin and urocortin in human adipose tissue in comparison with other peripheral tissues, adrenal, and heart.
7	14764822	CRH-R1:CRH-R2 ratio varied according to fat-depot type; whereas CRH-R1 expression was higher in sc fat than in visceral fat, the opposite was true for CRH-R2.
8	14764822	Adipose tissue also expressed urocortin and stresscopin, the predominant ligands of peripheral CRH-R2.
9	14764822	CRH down-regulated CRH-R1 and CRH-R2 mRNA expression in isolated adipocytes.
10	14764822	We characterized the expression of CRH receptors 1 and 2 and CRH-like peptides stresscopin and urocortin in human adipose tissue in comparison with other peripheral tissues, adrenal, and heart.
11	14764822	CRH-R1:CRH-R2 ratio varied according to fat-depot type; whereas CRH-R1 expression was higher in sc fat than in visceral fat, the opposite was true for CRH-R2.
12	14764822	Adipose tissue also expressed urocortin and stresscopin, the predominant ligands of peripheral CRH-R2.
13	14764822	CRH down-regulated CRH-R1 and CRH-R2 mRNA expression in isolated adipocytes.
14	15528398	Hindbrain neurons producing neuropeptide Y (NPY) and catecholamines (CA) then project to the forebrain where they contact GnRH neurons both directly and also indirectly via corticotropin-releasing hormone (CRH) neurons to inhibit GnRH secretion.
15	15528398	In the case of estrous behavior, the best available evidence suggests that the inhibitory NPY/CA system acts primarily via CRH or urocortin projections to various forebrain loci that control sexual receptivity.
16	15870911	Urocortin, a recently identified member of the corticotropin-releasing factor (CRF) family, is implicated in the central control of appetite and energy metabolism.
17	15870911	Urocortin decreased food intake and body weight gain more potently than CRF.
18	15870911	Urocortin, a recently identified member of the corticotropin-releasing factor (CRF) family, is implicated in the central control of appetite and energy metabolism.
19	15870911	Urocortin decreased food intake and body weight gain more potently than CRF.
20	16741581	The corticotrophin-releasing factor (CRF) family of neuropeptides and their receptors (CRFR1 and CRFR2) play a critical role in regulating the neuroendocrine stress response.
21	16741581	Here we show in the Sprague-Dawley rat that direct in vivo application to the ventromedial hypothalamus (VMH), a key glucose-sensing region, of urocortin I (UCN I), an endogenous CRFR2 agonist, suppressed (approximately 55-60%), whereas CRF, a predominantly CRFR1 agonist, amplified (approximately 50-70%) CRR to hypoglycemia.
22	16741581	Our data suggest that regulation of the CRR is largely determined by the interaction between CRFR2-mediated suppression and CRFR1-mediated activation in the VMH.
23	18398437	We describe the clinical, biochemical and molecular findings in a family with progressive myopathy, deafness and diabetes and striking respiratory chain abnormalities due to a well-characterized heteroplasmic mt-tRNA mutation in the mt-tRNA(Ser(UCN)) (MTTS1) gene.
24	19026699	Based on the reported anti-inflammatory and anti-stress responses by corticotropin-releasing factor (CRF) receptor signaling, endogenous CRF receptor agonists, CRF, urocortin (UCN) I and its related peptides, may play protective roles against cardiovascular stresses via the CRF receptor signaling.
25	19026699	In addition, due to the possible involvement of CRF receptor signaling in the effects of statin on endothelial cells, the effects of pitavastatin on the expression of UCN-related peptides in HAECs were also evaluated.
26	19026699	HAECs expressed all UCNs, CRF type 1 receptor (CRF-R1), and CRF type 2 (CRF-R2)alpha and CRF-R2beta mRNAs.
27	19026699	Real time PCR analysis revealed that UCN I mRNA was down-regulated, whereas UCN II mRNA was up-regulated by tumor necrosis factor (TNF)-alpha.
28	19026699	Selective blockade of CRF-R1 resulted in significant increase in TNF-alpha-induced expression of vascular adhesion molecule-1 at mRNA level and E-selectin at mRNA and protein levels.
29	19026699	On the contrary, UCN II, CRF-R1, and CRF-R2 mRNAs were markedly increased by co-incubation of pitavastatin and TNF-alpha.
30	19026699	These facts indicate that CRF-R1 signaling may have protective role against TNF-alpha-induced vascular inflammation.
31	19026699	In addition, because of up-regulation of CRF-R1 mRNA by pitavastatin with or without TNF-alpha, CRF-R1 may be involved in the vasoprotective effects of pitavastatin.
32	23219819	A novel MT-CO1 m.6498C>A variation associated with the m.7444G>A mutation in the mitochondrial COI/tRNA(Ser(UCN)) genes in a patient with hearing impairment, diabetes and congenital visual loss.
33	23219819	However, we detected the m.7444G>A mutation in the mitochondrial COI/tRNA(Ser(UCN)) genes.
34	23219819	The whole mitochondrial genome screening revealed the presence of a novel mutation m.6498C>A (L199I) in the mitochondrial DNA-encoded subunit I of the cytochrome c oxidase (COX).
35	23219819	A novel MT-CO1 m.6498C>A variation associated with the m.7444G>A mutation in the mitochondrial COI/tRNA(Ser(UCN)) genes in a patient with hearing impairment, diabetes and congenital visual loss.
36	23219819	However, we detected the m.7444G>A mutation in the mitochondrial COI/tRNA(Ser(UCN)) genes.
37	23219819	The whole mitochondrial genome screening revealed the presence of a novel mutation m.6498C>A (L199I) in the mitochondrial DNA-encoded subunit I of the cytochrome c oxidase (COX).