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Gene Information
Gene symbol: UGT1A4
Gene name: UDP glucuronosyltransferase 1 family, polypeptide A4
HGNC ID: 12536
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD244 | 1 hits |
| 2 | UGT1A | 1 hits |
| 3 | UGT1A3 | 1 hits |
| 4 | UGT1A6 | 1 hits |
| 5 | UGT1A9 | 1 hits |
| 6 | UGT2B7 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17359941 | With the assessment of MGN glucuronide formation across a panel of recombinant UDP-glucuronosyltransferase (UGT) isoforms (UGT1A3, UGT1A4, UGT1A6, UGT1A9, and UGT2B7), only UGT1A3 and UGT2B7 exhibited high MGN glucuronosyltransferase activity. |
| 2 | 17359941 | The K(m) values of MGN glucuronidation in recombinant UGT1A3 and UGT2B7 microsomes were close to those in human liver microsomes. |
| 3 | 17359941 | The formation of MGN glucuronidation by human liver microsomes was effectively inhibited by quercetin (substrate for UGT1A3) and diclofenac (substrate for UGT2B7), respectively. |
| 4 | 17359941 | These results demonstrate that UGT1A3 and UGT2B7 are catalytic enzymes in MGN carboxyl-glucuronidation in human liver. |
| 5 | 21422672 | Identification of the UDP-glucuronosyltransferase (UGT) isoforms involved in FA glucuronidation was investigated with 12 human recombinant enzymes. |
| 6 | 21422672 | FA was mainly glucuronidated by UGT1A isoforms and by UGT2B7. |
| 7 | 21422672 | UGT1A4, 2B4, 2B15 and 2B17 failed to glucuronidate the substance. |
| 8 | 21422672 | UGT1A6 and 1A8 were involved in the formation of the ether glucuronide only, whereas UGT1A7, 1A10 and 2B7 preferentially glucuronidated the carboxyl group. |