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Gene Information
Gene symbol: UNC13B
Gene name: unc-13 homolog B (C. elegans)
HGNC ID: 12566
Synonyms: hmunc13, Unc13h2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PLCB1 | 1 hits |
| 2 | UNC13A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9607201 | This strategy resulted in cloning of a novel gene in human MC, human munc13 (hmunc13), a human homologue of rat munc13s with the N-terminal segment similar to munc13-1 and the C-terminal segment more similar to munc13-2. |
| 2 | 12871971 | Regulation of insulin exocytosis by Munc13-1. |
| 3 | 12871971 | Expression of Munc13-1, along with its cognate partners, syntaxin 1a and Munc18a, is reduced in the pancreatic islets of type-2 diabetes non-obese Goto-Kakizaki and obese Zucker fa/fa rats. |
| 4 | 12871971 | The potentiation of exocytosis by Munc13-1 is dependent on endogenously produced diacylglycerol acting on the overexpressed Munc13-1 because it is blocked by a phospholipase C inhibitor (U73122) and abrogated when the diacylglycerol binding-deficient Munc13-1H567K mutant is expressed instead of the wild type protein. |
| 5 | 12871971 | In view of our findings, Munc13-1 is a potential drug target for therapeutic optimization of insulin secretion in diabetes. |