Ignet

Gene Information

Gene symbol: VCL

Gene name: vinculin

HGNC ID: 12665

Related Genes

#	Gene Symbol	Number of hits
1	ACTB	1 hits
2	ACTN4	1 hits
3	ADIPOQ	1 hits
4	AGT	1 hits
5	AGTR1	1 hits
6	ANXA1	1 hits
7	ANXA5	1 hits
8	APOA4	1 hits
9	BCAR1	1 hits
10	CAPG	1 hits
11	COL1A1	1 hits
12	DES	1 hits
13	DMD	1 hits
14	FABP4	1 hits
15	FN1	1 hits
16	GDA	1 hits
17	GSTCD	1 hits
18	GSTM2	1 hits
19	GSTP1	1 hits
20	HMGB1	1 hits
21	HSP90AB1	1 hits
22	HSPB1	1 hits
23	LASP1	1 hits
24	LDHB	1 hits
25	LPAL2	1 hits
26	MAPK1	1 hits
27	MSN	1 hits
28	MYH14	1 hits
29	MYH7	1 hits
30	PHGDH	1 hits
31	PLIN	1 hits
32	PMP22	1 hits
33	PPP2R1A	1 hits
34	PRDX2	1 hits
35	PRDX6	1 hits
36	PRKCA	1 hits
37	PTK2	1 hits
38	PTK2B	1 hits
39	PXN	1 hits
40	SELENBP1	1 hits
41	SERPINA1	1 hits
42	SERPINC1	1 hits
43	SRC	1 hits
44	TF	1 hits
45	TLN1	1 hits
46	TLN2	1 hits
47	TMOD3	1 hits
48	TNS1	1 hits
49	TTN	1 hits
50	TUBB2A	1 hits
51	TUBB3	1 hits
52	TUBB4	1 hits
53	TYK2	1 hits
54	VIM	1 hits

Related Sentences

#	PMID	Sentence
1	1581690	We have used immunohistochemical methods to demonstrate the intracellular localization of the proteins actin, myosin, tropomyosin and vinculin, which are thought to be responsible for cellular contraction, in 26 surgically obtained epiretinal traction membranes from patients with traumatic (n = 12) and idiopathic (n = 7) proliferative vitreoretinopathy, and proliferative diabetic retinopathy (n = 7).
2	9077489	We studied the immunolocalization of Dp116 (a 116 kDa protein product of the dystrophin gene), vinculin, talin, vimentin, desmin, spectrin and titin in the sural nerve biopsies of 25 patients with peripheral neuropathies of different origin. 4 patients presented with HMSN type 1, 4 with HMSN type 2, 2 with HNPP, 4 with CIDP, 5 with chronic axonal neuropathy of unknown origin, 3 with vasculitic neuropathy, 3 with diabetic neuropathy.
3	9077489	Expression and localization of Dp116, vinculin, vimentin, desmin, spectrin and titin did not differ from normal control cases.
4	9077489	Spectrin and titin immunoreactivities were absent and desmin was occasionally found in few epineurial vessels.
5	9077489	We studied the immunolocalization of Dp116 (a 116 kDa protein product of the dystrophin gene), vinculin, talin, vimentin, desmin, spectrin and titin in the sural nerve biopsies of 25 patients with peripheral neuropathies of different origin. 4 patients presented with HMSN type 1, 4 with HMSN type 2, 2 with HNPP, 4 with CIDP, 5 with chronic axonal neuropathy of unknown origin, 3 with vasculitic neuropathy, 3 with diabetic neuropathy.
6	9077489	Expression and localization of Dp116, vinculin, vimentin, desmin, spectrin and titin did not differ from normal control cases.
7	9077489	Spectrin and titin immunoreactivities were absent and desmin was occasionally found in few epineurial vessels.
8	14991332	Vinculin and focal adhesion kinase (FAK) were coprecipitated by tensin, suggesting that tensin can mediate signal transduction between cell and ECM through these molecules.
9	14991332	Tensin may play important roles in mesangial ECM production through an adhesion complex with integrin alpha5, FAK, and vinculin.
10	16141358	Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II.
11	16141358	Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1 receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium balance and its diverse pathological actions in cardiovascular, renal, and other cell types.
12	16141358	Ang II-induced AT1R activation via Gq/11 stimulates phospholipases A2, C, and D, and activates inositol trisphosphate/Ca2+ signaling, protein kinase C isoforms, and MAPKs, as well as several tyrosine kinases (Pyk2, Src, Tyk2, FAK), scaffold proteins (G protein-coupled receptor kinase-interacting protein 1, p130Cas, paxillin, vinculin), receptor tyrosine kinases, and the nuclear factor-kappaB pathway.
13	16141358	The AT1R also signals via Gi/o and G11/12 and stimulates G protein-independent signaling pathways, such as beta-arrestin-mediated MAPK activation and the Jak/STAT.
14	16141358	Many of the deleterious actions of AT1R activation are initiated by locally generated, rather than circulating, Ang II and are concomitant with the harmful effects of aldosterone in the cardiovascular system.
15	16141358	The recognition of Ang II's pathogenic actions is leading to novel clinical applications of angiotensin-converting enzyme inhibitors and AT1R antagonists, in addition to their established therapeutic actions in essential hypertension.
16	16267817	Expression changes in transferrin, vimentin, vinculin, peroxiredoxins, Rho-GTP dissociation inhibitor, grifin, guanine deaminase and 3-phosphoglycerate dehydrogenase were associated here for the first time with obesity.
17	18337374	A network analysis of these proteins using MetaCore suggested induction of transcriptional factors that are too low to be detected by two-dimensional DIGE and identified an enriched cluster of down-regulated proteins that are involved in cell adhesion, cell shape control, and motility, including vinculin, intermediate filaments, Ppp2r1a, and extracellular matrix proteins.
18	18337374	Mrlcb and Ly-GDI), in glycolysis (e.g. alpha-enolase and Taldo1), in mRNA processing (e.g. heterogeneous nuclear ribonucleoprotein A2/B1), in inflammatory response (e.g.
19	18337374	Tuba1 and Vil2).
20	18793745	The examples of such candidate proteins include several hubs, focal adhesion kinase PTK2 and the extracellular proteins fibronectin FN1, paxillin PXN, and vinculin VCL.
21	19952892	We will discuss the general function of vinculin/metavinulin as well as talin1 and talin2, with emphasis on what is understood about their role in the cardiac myocyte and in whole heart.
22	21136853	In T1DM with DN, beta-actin and three isoforms of tubulin beta-2 chain, tropomodulin-3, and LASP-1 were decreased, whereas two tubulin beta-4 chain isoforms, one alpha actinin-4 isoform, membrane-organizing extension spike protein (MOESIN), FLJ00279 (corresponding to a fragment of myosin heavy chain, non-muscle type A), vinculin, a tropomyosin isoform, and the macrophage capping protein were increased.
23	22378540	Impact of carbamylation and glycation of collagen type I on migration of HT1080 human fibrosarcoma cells.
24	22378540	In this in vitro study, we investigated the impact of carbamylated and glycated collagen type I on the migratory behavior of the highly invasive HT1080 human fibrosarcoma cells.
25	22378540	In addition, the influence of these collagen modifications on actin and vinculin organization was studied.
26	23709000	GDM was associated with an up-regulation of four proteins: collagen alpha-2(VI) chain (CO6A2 (COL6A2)), fibrinogen beta chain (FIBB (FGB)), lumican (LUM) and S100A9.
27	23709000	These were alpha-1-antitrypsin (AIAT (SERPINA 1)), annexin A5 (ANXA5), fatty acid-binding protein, adipocyte (FABP4), glutathione S-transferase P (GSTP (GSTP1)), heat-shock protein beta-1 (HSP27 (HSPB1)), lactate dehydrogenase B chain (LDHB), perilipin-1 (PLIN1), peroxiredoxin-6 (PRX6 (PRDX6)), selenium-binding protein 1 (SBP1) and vinculin (VINC (VCL)).
28	23791845	Diabetic patients showed increased VAT abundance of glutathione S-transferase Mu 2, peroxiredoxin-2, antithrombin-III, apolipoprotein A-IV, Ig κ chain C region, mitochondrial aldehyde dehydrogenase and actin, and decreased abundance of annexin-A1, retinaldehyde dehydrogenase-1, and vinculin, compared with their non-diabetic counterparts.