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Gene Information
Gene symbol: WNT2B
Gene name: wingless-type MMTV integration site family, member 2B
HGNC ID: 12781
Synonyms: XWNT2
Related Genes
Related Sentences
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PMID |
Sentence |
1 |
15754042
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Comparative genomics on Wnt5a and Wnt5b genes.
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2 |
15754042
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Canonical WNTs (WNT2, WNT2B, etc) activate the beta-catenin-TCF pathway to induce carcinogenesis, while non-canonical WNTs (WNT5A, WNT11, etc) activate the planar cell polarity (PCP) pathway to induce cell motility and metastasis.
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3 |
15754042
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WNT5A gene at chromosome 3p14.3 and WNT5B gene at chromosome 12p13.33 are paralogs within the human genome.
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4 |
15754042
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Here, we identified and characterized rat Wnt5a and Wnt5b genes by using bioinformatics.
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5 |
15754042
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Rat Wnt5a and Wnt5b genes, consisting of five exons, were identified within AC095764.5 and AC112027.3 genome sequences, respectively.
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6 |
15754042
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Rat Wnt5a (380 aa) and Wnt5b (359 aa) were secreted proteins with 24 conserved Cys residues and four Asn-linked glycosylation sites, which showed 75.8% total-amino-acid identity.
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7 |
15754042
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E47 and NKX2-5-binding sites were evolutionarily conserved among rat Wnt5a, mouse Wnt5a, and human WNT5A promoters.
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8 |
15754042
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This is the first report on rat Wnt5a and Wnt5b genes as well as on comparative genomics for Wnt5a and Wnt5b orthologs.
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9 |
19165345
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Multiple members of the Wnt signaling pathway, including TCF7L2, Wnt2b, beta-catenin, pGSK3beta, TCF3, cyclinD1, and c-myc, were undetectable or expressed at low levels in islets from nondiabetic individuals, but were also upregulated specifically in islets of type II diabetic patients.
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