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Gene Information

Gene symbol: WNT2B

Gene name: wingless-type MMTV integration site family, member 2B

HGNC ID: 12781

Synonyms: XWNT2

Related Genes

# Gene Symbol Number of hits
1 CTNNB1 1 hits
2 JUP 1 hits
3 MYC 1 hits
4 TCF7L1 1 hits
5 TCF7L2 1 hits
6 WNT11 1 hits
7 WNT2 1 hits
8 WNT5A 1 hits

Related Sentences

# PMID Sentence
1 15754042 Comparative genomics on Wnt5a and Wnt5b genes.
2 15754042 Canonical WNTs (WNT2, WNT2B, etc) activate the beta-catenin-TCF pathway to induce carcinogenesis, while non-canonical WNTs (WNT5A, WNT11, etc) activate the planar cell polarity (PCP) pathway to induce cell motility and metastasis.
3 15754042 WNT5A gene at chromosome 3p14.3 and WNT5B gene at chromosome 12p13.33 are paralogs within the human genome.
4 15754042 Here, we identified and characterized rat Wnt5a and Wnt5b genes by using bioinformatics.
5 15754042 Rat Wnt5a and Wnt5b genes, consisting of five exons, were identified within AC095764.5 and AC112027.3 genome sequences, respectively.
6 15754042 Rat Wnt5a (380 aa) and Wnt5b (359 aa) were secreted proteins with 24 conserved Cys residues and four Asn-linked glycosylation sites, which showed 75.8% total-amino-acid identity.
7 15754042 E47 and NKX2-5-binding sites were evolutionarily conserved among rat Wnt5a, mouse Wnt5a, and human WNT5A promoters.
8 15754042 This is the first report on rat Wnt5a and Wnt5b genes as well as on comparative genomics for Wnt5a and Wnt5b orthologs.
9 19165345 Multiple members of the Wnt signaling pathway, including TCF7L2, Wnt2b, beta-catenin, pGSK3beta, TCF3, cyclinD1, and c-myc, were undetectable or expressed at low levels in islets from nondiabetic individuals, but were also upregulated specifically in islets of type II diabetic patients.