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Gene Information
Gene symbol: WSB1
Gene name: WD repeat and SOCS box containing 1
HGNC ID: 19221
Synonyms: DKFZp564A122, DKFZp564B0482, SWIP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | DIO2 | 1 hits |
| 2 | GGH | 1 hits |
| 3 | MARCH6 | 1 hits |
| 4 | PARK2 | 1 hits |
| 5 | PTH | 1 hits |
| 6 | PTHLH | 1 hits |
| 7 | RNF123 | 1 hits |
| 8 | UBE2G2 | 1 hits |
| 9 | USP33 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15965468 | The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. |
| 2 | 15965468 | Here we show that WSB-1 is part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2). |
| 3 | 15965468 | In the developing tibial growth plate, Hedgehog-stimulated D2 ubiquitination via ECS(WSB-1) induces parathyroid hormone-related peptide (PTHrP), thereby regulating chondrocyte differentiation. |
| 4 | 15965468 | The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. |
| 5 | 15965468 | Here we show that WSB-1 is part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2). |
| 6 | 15965468 | In the developing tibial growth plate, Hedgehog-stimulated D2 ubiquitination via ECS(WSB-1) induces parathyroid hormone-related peptide (PTHrP), thereby regulating chondrocyte differentiation. |
| 7 | 15965468 | The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. |
| 8 | 15965468 | Here we show that WSB-1 is part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2). |
| 9 | 15965468 | In the developing tibial growth plate, Hedgehog-stimulated D2 ubiquitination via ECS(WSB-1) induces parathyroid hormone-related peptide (PTHrP), thereby regulating chondrocyte differentiation. |
| 10 | 17452445 | The D2 dimer associates with the Hedgehog-inducible ubiquitin ligase WSB-1, the ubiquitin conjugase UBC-7, and VDU-1, a D2-specific deubiquitinase. |
| 11 | 19651899 | The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. |
| 12 | 19651899 | While TEB4 expression predominates in the hematopoietic lineage, both WSB-1 and TEB4 are coexpressed with D2 in a number of tissues and cell types, except the thyroid and brown adipose tissue, where TEB4 expression is minimal. |
| 13 | 19651899 | We conclude that TEB4 interacts with and mediates loss of D2 activity, indicating that D2 ubiquitination and degradation can be tissue specific, depending on WSB-1 and TEB4 expression levels. |
| 14 | 19651899 | The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase. |
| 15 | 19651899 | While TEB4 expression predominates in the hematopoietic lineage, both WSB-1 and TEB4 are coexpressed with D2 in a number of tissues and cell types, except the thyroid and brown adipose tissue, where TEB4 expression is minimal. |
| 16 | 19651899 | We conclude that TEB4 interacts with and mediates loss of D2 activity, indicating that D2 ubiquitination and degradation can be tissue specific, depending on WSB-1 and TEB4 expression levels. |