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PMID |
Sentence |
1 |
19273592
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Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease.
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2 |
19273592
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We further show that Glis3 interacts with the transcriptional modulator Wwtr1/TAZ, which itself has been implicated in glomerulocystic kidney disease.
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3 |
19273592
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Wwtr1 recognizes a P/LPXY motif in the C terminus of Glis3 and enhances Glis3-mediated transcriptional activation, indicating that Wwtr1 functions as a coactivator of Glis3.
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4 |
19273592
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Mutations in the P/LPXY motif abrogate the interaction with Wwtr1 and the transcriptional activity of Glis3, indicating that this motif is part of the transcription activation domain of Glis3.
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5 |
19273592
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We propose that localization to the primary cilium and interaction with Wwtr1 are key elements of the Glis3 signaling pathway.
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6 |
19273592
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Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease.
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7 |
19273592
|
We further show that Glis3 interacts with the transcriptional modulator Wwtr1/TAZ, which itself has been implicated in glomerulocystic kidney disease.
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8 |
19273592
|
Wwtr1 recognizes a P/LPXY motif in the C terminus of Glis3 and enhances Glis3-mediated transcriptional activation, indicating that Wwtr1 functions as a coactivator of Glis3.
|
9 |
19273592
|
Mutations in the P/LPXY motif abrogate the interaction with Wwtr1 and the transcriptional activity of Glis3, indicating that this motif is part of the transcription activation domain of Glis3.
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10 |
19273592
|
We propose that localization to the primary cilium and interaction with Wwtr1 are key elements of the Glis3 signaling pathway.
|
11 |
19273592
|
Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease.
|
12 |
19273592
|
We further show that Glis3 interacts with the transcriptional modulator Wwtr1/TAZ, which itself has been implicated in glomerulocystic kidney disease.
|
13 |
19273592
|
Wwtr1 recognizes a P/LPXY motif in the C terminus of Glis3 and enhances Glis3-mediated transcriptional activation, indicating that Wwtr1 functions as a coactivator of Glis3.
|
14 |
19273592
|
Mutations in the P/LPXY motif abrogate the interaction with Wwtr1 and the transcriptional activity of Glis3, indicating that this motif is part of the transcription activation domain of Glis3.
|
15 |
19273592
|
We propose that localization to the primary cilium and interaction with Wwtr1 are key elements of the Glis3 signaling pathway.
|
16 |
19273592
|
Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease.
|
17 |
19273592
|
We further show that Glis3 interacts with the transcriptional modulator Wwtr1/TAZ, which itself has been implicated in glomerulocystic kidney disease.
|
18 |
19273592
|
Wwtr1 recognizes a P/LPXY motif in the C terminus of Glis3 and enhances Glis3-mediated transcriptional activation, indicating that Wwtr1 functions as a coactivator of Glis3.
|
19 |
19273592
|
Mutations in the P/LPXY motif abrogate the interaction with Wwtr1 and the transcriptional activity of Glis3, indicating that this motif is part of the transcription activation domain of Glis3.
|
20 |
19273592
|
We propose that localization to the primary cilium and interaction with Wwtr1 are key elements of the Glis3 signaling pathway.
|
21 |
19273592
|
Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease.
|
22 |
19273592
|
We further show that Glis3 interacts with the transcriptional modulator Wwtr1/TAZ, which itself has been implicated in glomerulocystic kidney disease.
|
23 |
19273592
|
Wwtr1 recognizes a P/LPXY motif in the C terminus of Glis3 and enhances Glis3-mediated transcriptional activation, indicating that Wwtr1 functions as a coactivator of Glis3.
|
24 |
19273592
|
Mutations in the P/LPXY motif abrogate the interaction with Wwtr1 and the transcriptional activity of Glis3, indicating that this motif is part of the transcription activation domain of Glis3.
|
25 |
19273592
|
We propose that localization to the primary cilium and interaction with Wwtr1 are key elements of the Glis3 signaling pathway.
|