Ignet

Gene Information

Gene symbol: XRCC4

Gene name: X-ray repair complementing defective repair in Chinese hamster cells 4

HGNC ID: 12831

Related Genes

#	Gene Symbol	Number of hits
1	DCLRE1C	1 hits
2	H2AFX	1 hits
3	LIG4	1 hits
4	MRE11A	1 hits
5	NBN	1 hits
6	PRKDC	1 hits
7	RAD50	1 hits

Related Sentences

#	PMID	Sentence
1	10202163	DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity.
2	10202163	Xrcc4 also binds to DNA ligase IV and enhances its joining activity.
3	10202163	DNA binding of Xrcc4 is correlated with its complementation of the V(D)J recombination defects in XRCC4-deficient cells, but is not required for stimulation of DNA ligase IV.
4	10202163	Thus, the ability of Xrcc4 to bind to DNA suggests functions independent of DNA ligase IV.
5	10202163	DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity.
6	10202163	Xrcc4 also binds to DNA ligase IV and enhances its joining activity.
7	10202163	DNA binding of Xrcc4 is correlated with its complementation of the V(D)J recombination defects in XRCC4-deficient cells, but is not required for stimulation of DNA ligase IV.
8	10202163	Thus, the ability of Xrcc4 to bind to DNA suggests functions independent of DNA ligase IV.
9	10202163	DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity.
10	10202163	Xrcc4 also binds to DNA ligase IV and enhances its joining activity.
11	10202163	DNA binding of Xrcc4 is correlated with its complementation of the V(D)J recombination defects in XRCC4-deficient cells, but is not required for stimulation of DNA ligase IV.
12	10202163	Thus, the ability of Xrcc4 to bind to DNA suggests functions independent of DNA ligase IV.
13	10202163	DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity.
14	10202163	Xrcc4 also binds to DNA ligase IV and enhances its joining activity.
15	10202163	DNA binding of Xrcc4 is correlated with its complementation of the V(D)J recombination defects in XRCC4-deficient cells, but is not required for stimulation of DNA ligase IV.
16	10202163	Thus, the ability of Xrcc4 to bind to DNA suggests functions independent of DNA ligase IV.
17	11080143	Xrcc4 protein forms a complex with DNA ligase IV that rejoins two DNA ends in the last step of V(D)J recombination and NHEJ to repair double strand breaks.
18	11080143	The C-terminal stalk comprising a single alpha-helix >120 A in length is partly incorporated into a four-helix bundle in the Xrcc4 tetramer and partly involved in interacting with ligase IV.
19	11080143	The Xrcc4 structure suggests a possible mode of coupling ligase IV association with DNA binding for effective ligation of DNA ends.
20	11080143	Xrcc4 protein forms a complex with DNA ligase IV that rejoins two DNA ends in the last step of V(D)J recombination and NHEJ to repair double strand breaks.
21	11080143	The C-terminal stalk comprising a single alpha-helix >120 A in length is partly incorporated into a four-helix bundle in the Xrcc4 tetramer and partly involved in interacting with ligase IV.
22	11080143	The Xrcc4 structure suggests a possible mode of coupling ligase IV association with DNA binding for effective ligation of DNA ends.
23	11080143	Xrcc4 protein forms a complex with DNA ligase IV that rejoins two DNA ends in the last step of V(D)J recombination and NHEJ to repair double strand breaks.
24	11080143	The C-terminal stalk comprising a single alpha-helix >120 A in length is partly incorporated into a four-helix bundle in the Xrcc4 tetramer and partly involved in interacting with ligase IV.
25	11080143	The Xrcc4 structure suggests a possible mode of coupling ligase IV association with DNA binding for effective ligation of DNA ends.
26	12045092	Recombination is initiated by the lymphoid-specific RAG1 and RAG2 proteins, which cooperate to make double-strand breaks at specific recognition sequences (recombination signal sequences, RSSs).
27	12045092	Broken ends are then processed and joined with the help of several factors also involved in repair of radiation-damaged DNA, including the DNA-dependent protein kinase (DNA-PK) and the Ku, Artemis, DNA ligase IV, and Xrcc4 proteins, and possibly histone H2AX and the Mre11/Rad50/Nbs1 complex.