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Gene Information
Gene symbol: ZHX2
Gene name: zinc fingers and homeoboxes 2
HGNC ID: 18513
Synonyms: KIAA0854
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GPLD1 | 1 hits |
| 2 | IGF1 | 1 hits |
| 3 | MAP2K1 | 1 hits |
| 4 | MAPK1 | 1 hits |
| 5 | MAPK10 | 1 hits |
| 6 | MAPK3 | 1 hits |
| 7 | MAPK6 | 1 hits |
| 8 | PIK3CA | 1 hits |
| 9 | PRKCZ | 1 hits |
| 10 | PTK2B | 1 hits |
| 11 | TYK2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11463795 | Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation. |
| 2 | 11463795 | Insulin controls glucose uptake by translocating GLUT4 and other glucose transporters to the plasma membrane in muscle and adipose tissues by a mechanism that appears to require protein kinase C (PKC)-zeta/lambda operating downstream of phosphatidylinositol 3-kinase. |
| 3 | 11463795 | Presently, we found that glucose acutely activated PKC-zeta/lambda in rat adipocytes and rat skeletal muscle preparations by a mechanism that was independent of phosphatidylinositol 3-kinase but, interestingly, dependent on the apparently sequential activation of the dantrolene-sensitive, nonreceptor proline-rich tyrosine kinase-2; components of the extracellular signal-regulated kinase (ERK) pathway, including, GRB2, SOS, RAS, RAF, MEK1 and ERK1/2; and, most interestingly, phospholipase D, thus yielding increases in phosphatidic acid, a known activator of PKC-zeta/lambda. |
| 4 | 11463795 | This activation of PKC-zeta/lambda, moreover, appeared to be required for glucose-induced increases in GLUT4 translocation and glucose transport in adipocytes and muscle cells. |
| 5 | 11561209 | Herein, a focal point is the mitochondrial control of specific death enzymes--so called caspases--by members of the pro-apoptotic Bax and BH3 subfamily or the anti-apoptotic Bcl-2 subfamily. |
| 6 | 11561209 | The insulin-like growth factors (IGFs) are potent proliferation factors and potently inhibit apoptosis acting via the ubiquitously expressed IGF-I receptor. |
| 7 | 11561209 | Within IGF-I receptor signalling, key to the inhibition of apoptosis are the RAS/RAF/mitogen-activated protein (MAP)-kinase pathway and the PI 3'-kinase pathway. |