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Gene Information
Gene symbol: ABCG1
Gene name: ATP-binding cassette, sub-family G (WHITE), member 1
HGNC ID: 73
Synonyms: ABC8
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCA1 | 1 hits |
| 2 | ABCA4 | 1 hits |
| 3 | SIRT6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 30998685 | Reverse cholesterol transport involves the transport of cholesterol to HDL by cellular ATP-binding cassette; ABCA1 and ABCG1 with subsequent delivery from peripheral tissues to the liver. |
| 2 | 30998685 | Cholesterol content, cholesterol efflux, and ABCA1 and ABCG1 mRNA expression were measured. |
| 3 | 30998685 | Kidney, spleen, and bone marrow-derived macrophages from APOL1-G1 and -G2 mice showed increased cholesterol accumulation and decreased ABCA1 and ABCG1 mRNA levels. |
| 4 | 30998685 | Reverse cholesterol transport involves the transport of cholesterol to HDL by cellular ATP-binding cassette; ABCA1 and ABCG1 with subsequent delivery from peripheral tissues to the liver. |
| 5 | 30998685 | Cholesterol content, cholesterol efflux, and ABCA1 and ABCG1 mRNA expression were measured. |
| 6 | 30998685 | Kidney, spleen, and bone marrow-derived macrophages from APOL1-G1 and -G2 mice showed increased cholesterol accumulation and decreased ABCA1 and ABCG1 mRNA levels. |
| 7 | 30998685 | Reverse cholesterol transport involves the transport of cholesterol to HDL by cellular ATP-binding cassette; ABCA1 and ABCG1 with subsequent delivery from peripheral tissues to the liver. |
| 8 | 30998685 | Cholesterol content, cholesterol efflux, and ABCA1 and ABCG1 mRNA expression were measured. |
| 9 | 30998685 | Kidney, spleen, and bone marrow-derived macrophages from APOL1-G1 and -G2 mice showed increased cholesterol accumulation and decreased ABCA1 and ABCG1 mRNA levels. |
| 10 | 32642006 | Sirt6 deficiency aggravates angiotensin II-induced cholesterol accumulation and injury in podocytes. |
| 11 | 32642006 | Methods: Bioinformatics analysis of renal biopsy specimens from patients with hypertensive nephropathy (HN) suggests the involvement of Sirtuin 6 (Sirt6) in Ang II-induced dysregulation of glomerular cholesterol. |
| 12 | 32642006 | Using a podocyte-specific Sirt6 knockout mouse model, the effects of Sirt6 on Ang II-induced cholesterol accumulation in podocytes and the therapeutic efficacies of cholesterol-lowering agents were evaluated. |
| 13 | 32642006 | Results: Cholesterol accumulation was detected in the podocytes of Ang II-infused mice, whereas selective deletion of Sirt6 in podocytes not only increased cholesterol accumulation in these cells but also exacerbated Ang II-induced kidney injury. |
| 14 | 32642006 | Deletion of Sirt6 also attenuated the protective effect of cyclodextrin (CD) on Ang II-induced urinary albumin excretion, glomerulosclerosis and podocyte injury. |
| 15 | 32642006 | In addition, we demonstrated that Sirt6 affected cholesterol efflux in podocytes by regulating the expression of ATP-binding cassette transporter G1 (ABCG1). |
| 16 | 32642006 | Conclusions: These findings provide evidence that Sirt6 is a potential target for renin-angiotensin system (RAS)-associated podocyte injury and provide a rationale for the application of cholesterol-lowering agents in patients with CKD. |