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Gene Information
Gene symbol: AKT2
Gene name: v-akt murine thymoma viral oncogene homolog 2
HGNC ID: 392
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | INS | 1 hits |
| 3 | IRS1 | 1 hits |
| 4 | MAP3K5 | 1 hits |
| 5 | MAPK1 | 1 hits |
| 6 | PIK3CA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 27083281 | The expression of podocyte specific genes CD2AP, podocalyxin, and synaptopodin and of the WT1 protein was evident in all cell lines. |
| 2 | 27083281 | Moreover, these cells showed enhanced phosphorylation of both Akt1 and Akt2 (isoforms of protein kinase B). |
| 3 | 28945024 | IR-related signaling pathways include insulin receptor substrate（IRS）/phosphatidylinositol 3 kinase（PI3K）/serine threonine kinase（Akt）pathway,adenosine monophosphate activated protein kinase（AMPK）pathway,glucose transporter4（GLUT4）pathway,nuclear factor（NF）-κB pathway and mitogen activated protein kinase（MAPK）pathway. |
| 4 | 28945024 | Among them,IRS1/PI3K/Akt2 is the main signaling pathway of IR in podocytes of glomeruli, thus intervening its activity can improve podocyte injury. |
| 5 | 30665571 | While the mechanisms are not fully understood, insulin activates both Akt2 and ERK, which inhibits apoptosis signal regulated kinase 1 (ASK1)-p38-induced apoptosis. |
| 6 | 30665571 | In cultured podocytes, hyperglycemia stimulated p38 signaling and induced apoptosis, which was reduced by insulin and ASK1 inhibition and enhanced by Akt or ERK inhibition. |