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Gene Information
Gene symbol: AMICA1
Gene name: adhesion molecule, interacts with CXADR antigen 1
HGNC ID: 19084
Synonyms: Gm638, AMICA
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MAGI1 | 1 hits |
| 2 | SIRT1 | 1 hits |
| 3 | SREBF1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16118391 | Junctional adhesion molecule 4 (JAM4) has been identified as a protein that interacts with membrane-associated guanyl kinase inverted (MAGI)-1 and is reported to be expressed on podocytes. |
| 2 | 16118391 | To elucidate the role of JAM4 on podocytes, we examined the expression of JAM4 and MAGI-1 in normal and two different proteinuric rat models: puromycin aminonucleoside (PAN) nephropathy and anti-nephrin antibody-induced (ANA) nephropathy, one model with and one without effacement of podocyte foot processes. |
| 3 | 16118391 | In proteinuric podocytes, the expression of JAM4 was distinct from that of MAGI-1 or other slit diaphragm molecules such as nephrin and ZO-1. |
| 4 | 16155592 | MAGUK with inverted domain structure-1 (MAGI-1) is a membrane-associated protein with one guanylate kinase, six PSD-95/Dlg-A/ZO-1 (PDZ), and two WW domains and is localized at tight junctions in epithelial cells. |
| 5 | 16155592 | In the previous study, we discovered a MAGI-1-interacting cell adhesion molecule junctional adhesion molecule 4 (JAM4). |
| 6 | 16155592 | Biochemical studies reveal that nephrin directly binds to the middle PDZ domains of MAGI-1 through its carboxyl terminus but does not bind to ZO-1. |
| 7 | 16155592 | MAGI-1 forms a tripartite complex with nephrin and JAM4 in vitro. |
| 8 | 16155592 | In puromycin aminonucleoside-induced nephrotic podocytes, MAGI-1 is localized with nephrin at the displaced slit diaphragm. |
| 9 | 16155592 | These data indicate that MAGI-1 is a component of the slit diaphragm and tightly interacts with nephrin and JAM4 in vivo. |
| 10 | 33186558 | We further demonstrated a novel role of JAML in regulating podocyte lipid metabolism through SIRT1-mediated SREBP1 signaling. |