Ignet

Gene Information

Gene symbol: APAF1

Gene name: apoptotic peptidase activating factor 1

HGNC ID: 576

Synonyms: CED4, APAF-1

Related Genes

#	Gene Symbol	Number of hits
1	BAX	1 hits
2	BCL2	1 hits
3	CASP3	1 hits
4	CASP7	1 hits
5	CASP9	1 hits
6	CYCS	1 hits
7	E2F3	1 hits
8	MARCH8	1 hits

Related Sentences

#	PMID	Sentence
1	28502979	Chrysin treatment dose-dependently restored the increased Bax/Bcl-2 ratio, and suppressed Apaf-1 induction and the elevated cytochrome c release in high glucose-exposed renal podocytes.
2	28502979	In addition, this compound improved the induction of slit diaphragm proteins podocin/nephrin in the diabetic glomeruli.
3	32696822	MicroRNA-770-5p contributes to podocyte injury via targeting E2F3 in diabetic nephropathy.
4	32696822	MicroRNA-770-5p depletion could repress high glucose (HG)-triggered apoptosis in podocytes, and downregulation of E2F transcription factor 3 (E2F3) could facilitate podocyte injury.
5	32696822	Nevertheless, whether E2F3 is involved in miR-770-5p knockdown-mediated improvement of DN is still unclear.
6	32696822	The expression levels of miR-770-5p and E2F3 were detected in HG-treated podocytes by RT-qPCR.
7	32696822	The expression levels of E2F3, apoptosis-related proteins Bcl-2 related X protein (Bax), B-cell lymphoma-2 (Bcl-2), Bad, apoptotic peptidase activating factor 1 (APAF1), C-caspase3, C-caspase7, and C-caspase9 were detected by western blot assay.
8	32696822	The effects of miR-770-5p and E2F3 on HG-treated podocytes proliferation and apoptosis were detected by CCK-8 and flow cytometry assays.
9	32696822	The interaction between miR-770-5p and E2F3 was predicted by Targetscan, and then verified by the dual-luciferase reporter assay.
10	32696822	MiR-770-5p was upregulated and E2F3 was downregulated in HG-treated podocytes.
11	32696822	MiR-770-5p inhibited proliferation and promoted apoptosis and E2F3 promoted proliferation and suppressed apoptosis in HG-treated podocytes.
12	32696822	E2F3 is a target gene of miR-770-5p and it partially abolished the effect of miR-770-5p in HG-triggered proliferation and apoptosis of podocytes.
13	32696822	MiR-770-5p deficiency blocked HG-induced APAF1/caspase9 pathway via targeting E2F3 in podocytes.
14	32696822	We firstly confirmed that E2F3 was a target of miR-770-5p in podocytes.
15	32696822	These findings suggested that miR-770-5p expedited podocyte injury by targeting E2F3, and the miR-770-5p/E2F3 axis might represent a pathological mechanism of DN progression.
16	32696822	MicroRNA-770-5p contributes to podocyte injury via targeting E2F3 in diabetic nephropathy.
17	32696822	MicroRNA-770-5p depletion could repress high glucose (HG)-triggered apoptosis in podocytes, and downregulation of E2F transcription factor 3 (E2F3) could facilitate podocyte injury.
18	32696822	Nevertheless, whether E2F3 is involved in miR-770-5p knockdown-mediated improvement of DN is still unclear.
19	32696822	The expression levels of miR-770-5p and E2F3 were detected in HG-treated podocytes by RT-qPCR.
20	32696822	The expression levels of E2F3, apoptosis-related proteins Bcl-2 related X protein (Bax), B-cell lymphoma-2 (Bcl-2), Bad, apoptotic peptidase activating factor 1 (APAF1), C-caspase3, C-caspase7, and C-caspase9 were detected by western blot assay.
21	32696822	The effects of miR-770-5p and E2F3 on HG-treated podocytes proliferation and apoptosis were detected by CCK-8 and flow cytometry assays.
22	32696822	The interaction between miR-770-5p and E2F3 was predicted by Targetscan, and then verified by the dual-luciferase reporter assay.
23	32696822	MiR-770-5p was upregulated and E2F3 was downregulated in HG-treated podocytes.
24	32696822	MiR-770-5p inhibited proliferation and promoted apoptosis and E2F3 promoted proliferation and suppressed apoptosis in HG-treated podocytes.
25	32696822	E2F3 is a target gene of miR-770-5p and it partially abolished the effect of miR-770-5p in HG-triggered proliferation and apoptosis of podocytes.
26	32696822	MiR-770-5p deficiency blocked HG-induced APAF1/caspase9 pathway via targeting E2F3 in podocytes.
27	32696822	We firstly confirmed that E2F3 was a target of miR-770-5p in podocytes.
28	32696822	These findings suggested that miR-770-5p expedited podocyte injury by targeting E2F3, and the miR-770-5p/E2F3 axis might represent a pathological mechanism of DN progression.