Ignet

Gene Information

Gene symbol: APCS

Gene name: amyloid P component, serum

HGNC ID: 584

Synonyms: SAP, PTX2, MGC88159

Related Genes

#	Gene Symbol	Number of hits
1	APLP2	1 hits
2	BCL2	1 hits
3	MAPK1	1 hits
4	STX2	1 hits

Related Sentences

#	PMID	Sentence
1	24566618	Protection of human podocytes from shiga toxin 2-induced phosphorylation of mitogen-activated protein kinases and apoptosis by human serum amyloid P component.
2	24566618	Human serum amyloid P component (SAP), a member of the pentraxin family, has been shown to protect against Stx2-induced lethality in mice in vivo, presumably by specific binding to the toxin.
3	24566618	To elucidate the mechanisms underlying podocyte injury in HUS-associated proteinuria, we assessed Stx2-induced activation of mitogen-activated protein kinases (MAPKs) and apoptosis in immortalized human podocytes and evaluated the impact of SAP on Stx2-induced damage.
4	24566618	Stx2 applied to cultured podocytes was internalized and then activated p38α MAPK and c-Jun N-terminal kinase (JNK), important signaling steps in cell differentiation and apoptosis.
5	24566618	Stx2 also activated caspase 3, resulting in an increased level of apoptosis.
6	24566618	Coincubation of podocytes with SAP and Stx2 mitigated the effects of Stx2 and induced upregulation of antiapoptotic Bcl2.
7	24566618	These data suggest that podocytes are a target of Stx2 and that SAP protects podocytes against Stx2-induced injury.
8	24566618	Protection of human podocytes from shiga toxin 2-induced phosphorylation of mitogen-activated protein kinases and apoptosis by human serum amyloid P component.
9	24566618	Human serum amyloid P component (SAP), a member of the pentraxin family, has been shown to protect against Stx2-induced lethality in mice in vivo, presumably by specific binding to the toxin.
10	24566618	To elucidate the mechanisms underlying podocyte injury in HUS-associated proteinuria, we assessed Stx2-induced activation of mitogen-activated protein kinases (MAPKs) and apoptosis in immortalized human podocytes and evaluated the impact of SAP on Stx2-induced damage.
11	24566618	Stx2 applied to cultured podocytes was internalized and then activated p38α MAPK and c-Jun N-terminal kinase (JNK), important signaling steps in cell differentiation and apoptosis.
12	24566618	Stx2 also activated caspase 3, resulting in an increased level of apoptosis.
13	24566618	Coincubation of podocytes with SAP and Stx2 mitigated the effects of Stx2 and induced upregulation of antiapoptotic Bcl2.
14	24566618	These data suggest that podocytes are a target of Stx2 and that SAP protects podocytes against Stx2-induced injury.
15	24566618	Protection of human podocytes from shiga toxin 2-induced phosphorylation of mitogen-activated protein kinases and apoptosis by human serum amyloid P component.
16	24566618	Human serum amyloid P component (SAP), a member of the pentraxin family, has been shown to protect against Stx2-induced lethality in mice in vivo, presumably by specific binding to the toxin.
17	24566618	To elucidate the mechanisms underlying podocyte injury in HUS-associated proteinuria, we assessed Stx2-induced activation of mitogen-activated protein kinases (MAPKs) and apoptosis in immortalized human podocytes and evaluated the impact of SAP on Stx2-induced damage.
18	24566618	Stx2 applied to cultured podocytes was internalized and then activated p38α MAPK and c-Jun N-terminal kinase (JNK), important signaling steps in cell differentiation and apoptosis.
19	24566618	Stx2 also activated caspase 3, resulting in an increased level of apoptosis.
20	24566618	Coincubation of podocytes with SAP and Stx2 mitigated the effects of Stx2 and induced upregulation of antiapoptotic Bcl2.
21	24566618	These data suggest that podocytes are a target of Stx2 and that SAP protects podocytes against Stx2-induced injury.
22	24566618	Protection of human podocytes from shiga toxin 2-induced phosphorylation of mitogen-activated protein kinases and apoptosis by human serum amyloid P component.
23	24566618	Human serum amyloid P component (SAP), a member of the pentraxin family, has been shown to protect against Stx2-induced lethality in mice in vivo, presumably by specific binding to the toxin.
24	24566618	To elucidate the mechanisms underlying podocyte injury in HUS-associated proteinuria, we assessed Stx2-induced activation of mitogen-activated protein kinases (MAPKs) and apoptosis in immortalized human podocytes and evaluated the impact of SAP on Stx2-induced damage.
25	24566618	Stx2 applied to cultured podocytes was internalized and then activated p38α MAPK and c-Jun N-terminal kinase (JNK), important signaling steps in cell differentiation and apoptosis.
26	24566618	Stx2 also activated caspase 3, resulting in an increased level of apoptosis.
27	24566618	Coincubation of podocytes with SAP and Stx2 mitigated the effects of Stx2 and induced upregulation of antiapoptotic Bcl2.
28	24566618	These data suggest that podocytes are a target of Stx2 and that SAP protects podocytes against Stx2-induced injury.
29	24566618	Protection of human podocytes from shiga toxin 2-induced phosphorylation of mitogen-activated protein kinases and apoptosis by human serum amyloid P component.
30	24566618	Human serum amyloid P component (SAP), a member of the pentraxin family, has been shown to protect against Stx2-induced lethality in mice in vivo, presumably by specific binding to the toxin.
31	24566618	To elucidate the mechanisms underlying podocyte injury in HUS-associated proteinuria, we assessed Stx2-induced activation of mitogen-activated protein kinases (MAPKs) and apoptosis in immortalized human podocytes and evaluated the impact of SAP on Stx2-induced damage.
32	24566618	Stx2 applied to cultured podocytes was internalized and then activated p38α MAPK and c-Jun N-terminal kinase (JNK), important signaling steps in cell differentiation and apoptosis.
33	24566618	Stx2 also activated caspase 3, resulting in an increased level of apoptosis.
34	24566618	Coincubation of podocytes with SAP and Stx2 mitigated the effects of Stx2 and induced upregulation of antiapoptotic Bcl2.
35	24566618	These data suggest that podocytes are a target of Stx2 and that SAP protects podocytes against Stx2-induced injury.