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Gene Information
Gene symbol: ARHGAP1
Gene name: Rho GTPase activating protein 1
HGNC ID: 673
Synonyms: RhoGAP, p50rhoGAP, CDC42GAP, Cdc42GAP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ARHGAP5 | 1 hits |
| 2 | MYH14 | 1 hits |
| 3 | ROBO2 | 1 hits |
| 4 | SRGAP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 27882344 | SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion. |
| 2 | 27882344 | The repulsive guidance cue SLIT2 and its receptor ROBO2 are required for kidney development and podocyte foot process structure, but the SLIT2/ROBO2 signaling mechanism regulating podocyte function is not known. |
| 3 | 27882344 | Here we report that a potentially novel signaling pathway consisting of SLIT/ROBO Rho GTPase activating protein 1 (SRGAP1) and nonmuscle myosin IIA (NMIIA) regulates podocyte adhesion downstream of ROBO2. |
| 4 | 27882344 | We found that the myosin II regulatory light chain (MRLC), a subunit of NMIIA, interacts directly with SRGAP1 and forms a complex with ROBO2/SRGAP1/NMIIA in the presence of SLIT2. |
| 5 | 27882344 | Immunostaining demonstrated that SRGAP1 is a podocyte protein and is colocalized with ROBO2 on the basal surface of podocytes. |
| 6 | 27882344 | In addition, SLIT2 stimulation inhibits NMIIA activity, decreases focal adhesion formation, and reduces podocyte attachment to collagen. |
| 7 | 27882344 | In vivo studies further showed that podocyte-specific knockout of Robo2 protects mice from hypertension-induced podocyte detachment and albuminuria and also partially rescues the podocyte-loss phenotype in Myh9 knockout mice. |
| 8 | 27882344 | Thus, we have identified SLIT2/ROBO2/SRGAP1/NMIIA as a potentially novel signaling pathway in kidney podocytes, which may play a role in regulating podocyte adhesion and attachment. |
| 9 | 27882344 | Our findings also suggest that SLIT2/ROBO2 signaling might be a therapeutic target for kidney diseases associated with podocyte detachment and loss. |