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Gene Information
Gene symbol: ATIC
Gene name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
HGNC ID: 794
Synonyms: PURH, AICARFT, IMPCHASE
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACACB | 1 hits |
| 2 | ADIPOQ | 1 hits |
| 3 | ADIPOR1 | 1 hits |
| 4 | CCL26 | 1 hits |
| 5 | MAP1LC3A | 1 hits |
| 6 | NPHS1 | 1 hits |
| 7 | NPHS2 | 1 hits |
| 8 | PRKAA1 | 1 hits |
| 9 | PRKAA2 | 1 hits |
| 10 | SYNPO | 1 hits |
| 11 | TSC1 | 1 hits |
| 12 | ULK1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18941912 | Adiponectin stimulates phosphorylation of AMP-activated protein kinase alpha in renal glomeruli. |
| 2 | 18941912 | Adiponectin receptor ADIPOR1 activates the intracellular second messenger AMP-activated protein kinase (AMPK) that participates in the control of the oxidative stress and apoptosis. |
| 3 | 18941912 | ADIPOR1 and catalytic AMPK sub-units alpha1 and alpha2 were revealed in normal rat glomeruli and incubation of freshly isolated rat glomeruli with either adiponectin or AICAR led to the activation by phosphorylation of catalytic AMPK. |
| 4 | 18941912 | It is concluded that glomerular cells express a functional adiponectin receptor ADIPOR1 which, through activation of AMPK, may play important roles in the control of oxidative stress and cell survival within the glomerulus. |
| 5 | 29175208 | A single nucleotide polymorphism (SNP) within the acetyl CoA carboxylase (ACC) β gene (ACACB), rs2268388, has been shown to be associated with susceptibility to development of proteinuria in patients with type 2 diabetes. |
| 6 | 29175208 | In STZ-induced diabetic mice, ACACB-transgenic mice showed a significant increase in urinary albumin excretion, accompanied by decreased synaptopodin expression and podocin mislocalization in podocytes, compared with wild-type mice. |
| 7 | 29175208 | In cultured murine podocytes, overexpression of ACACB significantly decreased synaptopodin expression and reorganized stress fibers under high glucose conditions, but not in normal glucose conditions. |
| 8 | 29175208 | The decrease of synaptopodin expression and reorganized stress fibers observed in ACACB overexpressing cells cultured under high glucose conditions was reversed by a treatment of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR), activator of AMP-activated protein kinase (AMPK). |
| 9 | 31865844 | Instead we present data showing that autophagy in podocytes is mainly controlled by AMP-activated protein kinase (AMPK) and ULK1 (unc-51 like kinase 1). |
| 10 | 31865844 | Abbreviations: AICAR: 5-aminoimidazole-4-carboxamide ribonucleotide; AMPK: AMP-activated protein kinase; ATG: autophagy related; BW: body weight; Cq: chloroquine; ER: endoplasmic reticulum; ESRD: end stage renal disease; FACS: fluorescence activated cell sorting; GFP: green fluorescent protein; i.p.: intra peritoneal; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MTOR: mechanistic target of rapamycin kinase; NPHS1: nephrosis 1, nephrin; NPHS2: nephrosis 2, podocin; PLA: proximity-ligation assay; PRKAA: 5'-AMP-activated protein kinase catalytic subunit alpha; RPTOR/RAPTOR: regulatory associated protein of MTOR, complex 1; RFP: red fluorescent protein; TSC1: tuberous sclerosis 1; ULK1: unc-51 like kinase 1. |