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Gene Information
Gene symbol: BAMBI
Gene name: BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)
HGNC ID: 30251
Synonyms: NMA
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INHBE | 1 hits |
| 2 | NOS3 | 1 hits |
| 3 | SMAD3 | 1 hits |
| 4 | TGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 32739209 | The effect of TGF-β, mediated by the type I TGF-β receptor, ALK5, and subsequent Smad2/3 activation results in podocyte apoptosis and loss. |
| 2 | 32739209 | This was associated with heightened ALK1-mediated activation of Smad1/5 in the glomerular endothelial cells (ECs). |
| 3 | 32739209 | Therefore, to evaluate the glomerular cell-specific effects of TGF-β in diabetic nephropathy we examined the effects of the podocyte- or EC-specific loss of Bambi (Pod-Bambi-/- or EC-Bambi-/-) in streptozotocin-induced diabetic mice with endothelial nitric oxide synthase deficiency. |
| 4 | 32739209 | While the podocyte or EC-specific loss of BAMBI both accelerated the progression of diabetic nephropathy, the worsened podocyte injury and loss observed in the diabetic Pod-Bambi-/- mice were associated with enhanced Smad3 activation. |
| 5 | 32739209 | The enhanced Smad1/5 activation in diabetic EC-Bambi-/- mice was associated with increased glomerular expression of plasmalemma vesicle-associated protein, pointing to the involvement of immature or dedifferentiated glomerular ECs in diabetic nephropathy. |
| 6 | 32739209 | The effect of TGF-β, mediated by the type I TGF-β receptor, ALK5, and subsequent Smad2/3 activation results in podocyte apoptosis and loss. |
| 7 | 32739209 | This was associated with heightened ALK1-mediated activation of Smad1/5 in the glomerular endothelial cells (ECs). |
| 8 | 32739209 | Therefore, to evaluate the glomerular cell-specific effects of TGF-β in diabetic nephropathy we examined the effects of the podocyte- or EC-specific loss of Bambi (Pod-Bambi-/- or EC-Bambi-/-) in streptozotocin-induced diabetic mice with endothelial nitric oxide synthase deficiency. |
| 9 | 32739209 | While the podocyte or EC-specific loss of BAMBI both accelerated the progression of diabetic nephropathy, the worsened podocyte injury and loss observed in the diabetic Pod-Bambi-/- mice were associated with enhanced Smad3 activation. |
| 10 | 32739209 | The enhanced Smad1/5 activation in diabetic EC-Bambi-/- mice was associated with increased glomerular expression of plasmalemma vesicle-associated protein, pointing to the involvement of immature or dedifferentiated glomerular ECs in diabetic nephropathy. |
| 11 | 32828232 | Furthermore, they showed that bone morphogenetic protein (BMP) and activin membrane-bound inhibitor, an endogenous modulator of transforming growth factor-β signaling, plays a cell type-specific role and may be a good target for intervention against diabetic kidney disease. |