Ignet

Gene Information

Gene symbol: BASP1

Gene name: brain abundant, membrane attached signal protein 1

HGNC ID: 957

Synonyms: NAP-22, NAP22, CAP23, CAP-23

Related Genes

#	Gene Symbol	Number of hits
1	BAK1	1 hits
2	MYC	1 hits
3	RPL10	1 hits
4	SRPK1	1 hits
5	WT1	1 hits

Related Sentences

#	PMID	Sentence
1	14701728	BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1.
2	14701728	The Wilms' tumor suppressor protein WT1 is a transcriptional regulator that plays a key role in the development of the kidneys.
3	14701728	WT1 and BASP1 associate within the nuclei of cells that naturally express both proteins.
4	14701728	BASP1 can confer WT1 cosuppressor activity in transfection assays, and elimination of endogenous BASP1 expression augments transcriptional activation by WT1.
5	14701728	BASP1 is present in the developing nephron structures of the embryonic kidney and, coincident with that of WT1, its expression is restricted to the highly specialized podocyte cells of the adult kidney.
6	14701728	Taken together, our results show that BASP1 is a WT1-associated factor that can regulate WT1 transcriptional activity.
7	14701728	BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1.
8	14701728	The Wilms' tumor suppressor protein WT1 is a transcriptional regulator that plays a key role in the development of the kidneys.
9	14701728	WT1 and BASP1 associate within the nuclei of cells that naturally express both proteins.
10	14701728	BASP1 can confer WT1 cosuppressor activity in transfection assays, and elimination of endogenous BASP1 expression augments transcriptional activation by WT1.
11	14701728	BASP1 is present in the developing nephron structures of the embryonic kidney and, coincident with that of WT1, its expression is restricted to the highly specialized podocyte cells of the adult kidney.
12	14701728	Taken together, our results show that BASP1 is a WT1-associated factor that can regulate WT1 transcriptional activity.
13	14701728	BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1.
14	14701728	The Wilms' tumor suppressor protein WT1 is a transcriptional regulator that plays a key role in the development of the kidneys.
15	14701728	WT1 and BASP1 associate within the nuclei of cells that naturally express both proteins.
16	14701728	BASP1 can confer WT1 cosuppressor activity in transfection assays, and elimination of endogenous BASP1 expression augments transcriptional activation by WT1.
17	14701728	BASP1 is present in the developing nephron structures of the embryonic kidney and, coincident with that of WT1, its expression is restricted to the highly specialized podocyte cells of the adult kidney.
18	14701728	Taken together, our results show that BASP1 is a WT1-associated factor that can regulate WT1 transcriptional activity.
19	14701728	BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1.
20	14701728	The Wilms' tumor suppressor protein WT1 is a transcriptional regulator that plays a key role in the development of the kidneys.
21	14701728	WT1 and BASP1 associate within the nuclei of cells that naturally express both proteins.
22	14701728	BASP1 can confer WT1 cosuppressor activity in transfection assays, and elimination of endogenous BASP1 expression augments transcriptional activation by WT1.
23	14701728	BASP1 is present in the developing nephron structures of the embryonic kidney and, coincident with that of WT1, its expression is restricted to the highly specialized podocyte cells of the adult kidney.
24	14701728	Taken together, our results show that BASP1 is a WT1-associated factor that can regulate WT1 transcriptional activity.
25	14701728	BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1.
26	14701728	The Wilms' tumor suppressor protein WT1 is a transcriptional regulator that plays a key role in the development of the kidneys.
27	14701728	WT1 and BASP1 associate within the nuclei of cells that naturally express both proteins.
28	14701728	BASP1 can confer WT1 cosuppressor activity in transfection assays, and elimination of endogenous BASP1 expression augments transcriptional activation by WT1.
29	14701728	BASP1 is present in the developing nephron structures of the embryonic kidney and, coincident with that of WT1, its expression is restricted to the highly specialized podocyte cells of the adult kidney.
30	14701728	Taken together, our results show that BASP1 is a WT1-associated factor that can regulate WT1 transcriptional activity.
31	19050011	Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation.
32	19050011	We previously identified Brain Acid Soluble Protein 1 (BASP1) as a transcriptional cosuppressor that can block the transcriptional activation function of WT1.
33	19050011	WT1 and BASP1 are co-expressed during nephrogenesis and both proteins ultimately become restricted to the podocyte cells of the adult kidney.
34	19050011	Here, we have analysed the WT1/BASP1 complex in a podocyte precursor cell line that can be induced to differentiate.
35	19050011	Chromatin immunoprecipitation revealed that WT1 and BASP1 occupy the promoters of the Bak, c-myc and podocalyxin genes in podocyte precursor cells.
36	19050011	During differentiation-dependent upregulation of podocalyxin expression BASP1 occupancy of the podocalyxin promoter is reduced compared to that of WT1.
37	19050011	In contrast, the repressive WT1/BASP1 occupancy of the c-myc and Bak promoters is maintained and these genes are downregulated during the differentiation process.
38	19050011	Our results reveal a dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation.
39	19050011	Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation.
40	19050011	We previously identified Brain Acid Soluble Protein 1 (BASP1) as a transcriptional cosuppressor that can block the transcriptional activation function of WT1.
41	19050011	WT1 and BASP1 are co-expressed during nephrogenesis and both proteins ultimately become restricted to the podocyte cells of the adult kidney.
42	19050011	Here, we have analysed the WT1/BASP1 complex in a podocyte precursor cell line that can be induced to differentiate.
43	19050011	Chromatin immunoprecipitation revealed that WT1 and BASP1 occupy the promoters of the Bak, c-myc and podocalyxin genes in podocyte precursor cells.
44	19050011	During differentiation-dependent upregulation of podocalyxin expression BASP1 occupancy of the podocalyxin promoter is reduced compared to that of WT1.
45	19050011	In contrast, the repressive WT1/BASP1 occupancy of the c-myc and Bak promoters is maintained and these genes are downregulated during the differentiation process.
46	19050011	Our results reveal a dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation.
47	19050011	Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation.
48	19050011	We previously identified Brain Acid Soluble Protein 1 (BASP1) as a transcriptional cosuppressor that can block the transcriptional activation function of WT1.
49	19050011	WT1 and BASP1 are co-expressed during nephrogenesis and both proteins ultimately become restricted to the podocyte cells of the adult kidney.
50	19050011	Here, we have analysed the WT1/BASP1 complex in a podocyte precursor cell line that can be induced to differentiate.
51	19050011	Chromatin immunoprecipitation revealed that WT1 and BASP1 occupy the promoters of the Bak, c-myc and podocalyxin genes in podocyte precursor cells.
52	19050011	During differentiation-dependent upregulation of podocalyxin expression BASP1 occupancy of the podocalyxin promoter is reduced compared to that of WT1.
53	19050011	In contrast, the repressive WT1/BASP1 occupancy of the c-myc and Bak promoters is maintained and these genes are downregulated during the differentiation process.
54	19050011	Our results reveal a dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation.
55	19050011	Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation.
56	19050011	We previously identified Brain Acid Soluble Protein 1 (BASP1) as a transcriptional cosuppressor that can block the transcriptional activation function of WT1.
57	19050011	WT1 and BASP1 are co-expressed during nephrogenesis and both proteins ultimately become restricted to the podocyte cells of the adult kidney.
58	19050011	Here, we have analysed the WT1/BASP1 complex in a podocyte precursor cell line that can be induced to differentiate.
59	19050011	Chromatin immunoprecipitation revealed that WT1 and BASP1 occupy the promoters of the Bak, c-myc and podocalyxin genes in podocyte precursor cells.
60	19050011	During differentiation-dependent upregulation of podocalyxin expression BASP1 occupancy of the podocalyxin promoter is reduced compared to that of WT1.
61	19050011	In contrast, the repressive WT1/BASP1 occupancy of the c-myc and Bak promoters is maintained and these genes are downregulated during the differentiation process.
62	19050011	Our results reveal a dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation.
63	19050011	Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation.
64	19050011	We previously identified Brain Acid Soluble Protein 1 (BASP1) as a transcriptional cosuppressor that can block the transcriptional activation function of WT1.
65	19050011	WT1 and BASP1 are co-expressed during nephrogenesis and both proteins ultimately become restricted to the podocyte cells of the adult kidney.
66	19050011	Here, we have analysed the WT1/BASP1 complex in a podocyte precursor cell line that can be induced to differentiate.
67	19050011	Chromatin immunoprecipitation revealed that WT1 and BASP1 occupy the promoters of the Bak, c-myc and podocalyxin genes in podocyte precursor cells.
68	19050011	During differentiation-dependent upregulation of podocalyxin expression BASP1 occupancy of the podocalyxin promoter is reduced compared to that of WT1.
69	19050011	In contrast, the repressive WT1/BASP1 occupancy of the c-myc and Bak promoters is maintained and these genes are downregulated during the differentiation process.
70	19050011	Our results reveal a dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation.
71	19050011	Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation.
72	19050011	We previously identified Brain Acid Soluble Protein 1 (BASP1) as a transcriptional cosuppressor that can block the transcriptional activation function of WT1.
73	19050011	WT1 and BASP1 are co-expressed during nephrogenesis and both proteins ultimately become restricted to the podocyte cells of the adult kidney.
74	19050011	Here, we have analysed the WT1/BASP1 complex in a podocyte precursor cell line that can be induced to differentiate.
75	19050011	Chromatin immunoprecipitation revealed that WT1 and BASP1 occupy the promoters of the Bak, c-myc and podocalyxin genes in podocyte precursor cells.
76	19050011	During differentiation-dependent upregulation of podocalyxin expression BASP1 occupancy of the podocalyxin promoter is reduced compared to that of WT1.
77	19050011	In contrast, the repressive WT1/BASP1 occupancy of the c-myc and Bak promoters is maintained and these genes are downregulated during the differentiation process.
78	19050011	Our results reveal a dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation.
79	19050011	Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation.
80	19050011	We previously identified Brain Acid Soluble Protein 1 (BASP1) as a transcriptional cosuppressor that can block the transcriptional activation function of WT1.
81	19050011	WT1 and BASP1 are co-expressed during nephrogenesis and both proteins ultimately become restricted to the podocyte cells of the adult kidney.
82	19050011	Here, we have analysed the WT1/BASP1 complex in a podocyte precursor cell line that can be induced to differentiate.
83	19050011	Chromatin immunoprecipitation revealed that WT1 and BASP1 occupy the promoters of the Bak, c-myc and podocalyxin genes in podocyte precursor cells.
84	19050011	During differentiation-dependent upregulation of podocalyxin expression BASP1 occupancy of the podocalyxin promoter is reduced compared to that of WT1.
85	19050011	In contrast, the repressive WT1/BASP1 occupancy of the c-myc and Bak promoters is maintained and these genes are downregulated during the differentiation process.
86	19050011	Our results reveal a dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation.
87	19050011	Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation.
88	19050011	We previously identified Brain Acid Soluble Protein 1 (BASP1) as a transcriptional cosuppressor that can block the transcriptional activation function of WT1.
89	19050011	WT1 and BASP1 are co-expressed during nephrogenesis and both proteins ultimately become restricted to the podocyte cells of the adult kidney.
90	19050011	Here, we have analysed the WT1/BASP1 complex in a podocyte precursor cell line that can be induced to differentiate.
91	19050011	Chromatin immunoprecipitation revealed that WT1 and BASP1 occupy the promoters of the Bak, c-myc and podocalyxin genes in podocyte precursor cells.
92	19050011	During differentiation-dependent upregulation of podocalyxin expression BASP1 occupancy of the podocalyxin promoter is reduced compared to that of WT1.
93	19050011	In contrast, the repressive WT1/BASP1 occupancy of the c-myc and Bak promoters is maintained and these genes are downregulated during the differentiation process.
94	19050011	Our results reveal a dynamic cooperation between WT1 and BASP1 in the regulation of gene expression during differentiation.
95	33017668	WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1.
96	33017668	In glomerular podocytes, the Wilms tumour suppressor zinc-finger transcription factor WT1 represses SRPK1 transcription.
97	33017668	Here we show that in cancer cells WT1 activates SRPK1 transcription, unless a canonical WT1 binding site adjacent to the transcription start site is mutated.
98	33017668	The ability of WT1 to activate SRPK1 transcription was reversed by the transcriptional corepressor BASP1, and both WT1 and BASP1 co-precipitated with the SRPK1 promoter.
99	33017668	We propose that by upregulating SRPK1 transcription WT1 can direct an alternative splicing landscape that facilitates tumour growth.