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Gene Information
Gene symbol: CABP2
Gene name: calcium binding protein 2
HGNC ID: 1385
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGT | 1 hits |
| 2 | MIRN17 | 1 hits |
| 3 | SMOC2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 33835671 | MicroRNA-17-5p restrains the dysfunction of Ang-II induced podocytes by suppressing secreted modular calcium-binding protein 2 via NF-κB and TGFβ signaling. |
| 2 | 33835671 | In the current study, RT-qPCR analysis showed that miR-17-5p was downregulated in Ang II-induced podocytes. |
| 3 | 33835671 | Also, according to the results from RT-qPCR analysis, CCK-8 assay, flow cytometric analysis, western blot analysis, and ELISA miR-17-5p elevation alleviated Ang II-induced podocyte injury. |
| 4 | 33835671 | Besides, luciferase reporter assay, western blot and RT-qPCR analyses revealed that SMOC2 was targeted by miR-17-5p in Ang II-induced podocytes. |
| 5 | 33835671 | Additionally, rescue assays demonstrated that overexpressed SMOC2 counteracted the influence of overexpressed miR-17-5p on cell injury of Ang II-induced podocytes. |
| 6 | 33835671 | Moreover, our data suggested that miR-17-5p-SMOC2 axis regulated TGFβ and NF-κB signaling activation in Ang II-induced podocytes. |
| 7 | 33835671 | SMOC2 regulated cell viability, apoptosis and extracellular matrix (ECM) deposition in Ang II-induced podocytes via TGFβ signaling, and SMOC2 regulated inflammation in Ang II-induced podocytes through NF-κB signaling. |
| 8 | 33835671 | Overall, our study demonstrated that miRNA-17-5p restrained the dysfunction of Ang-II induced podocytes by suppressing SMOC2 via the NF-κB and TGFβ signaling. |