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Gene Information
Gene symbol: CAMK2B
Gene name: calcium/calmodulin-dependent protein kinase II beta
HGNC ID: 1461
Synonyms: CAM2, CAMK2
Related Genes
Related Sentences
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PMID |
Sentence |
1 |
29985166
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We report that podocytes from patients with lupus nephritis and focal segmental glomerulosclerosis and lupus-prone and lipopolysaccharide- or adriamycin-treated mice display increased expression of CaMK IV (CaMK4), but not CaMK2.
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2 |
29985166
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Mechanistically, CaMK4 modulated podocyte motility by altering the expression of the GTPases Rac1 and RhoA and suppressed the expression of nephrin, synaptopodin, and actin fibers in podocytes.
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3 |
29985166
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Targeted delivery of a CaMK4 inhibitor to podocytes preserved their ultrastructure, averted immune complex deposition and crescent formation, and suppressed proteinuria in lupus-prone mice and proteinuria in mice exposed to lipopolysaccharide-induced podocyte injury by preserving nephrin/synaptopodin expression.
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