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Gene Information
Gene symbol: CASP4
Gene name: caspase 4, apoptosis-related cysteine peptidase
HGNC ID: 1505
Synonyms: ICE(rel)II, ICH-2, TX
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL18 | 1 hits |
| 2 | IL1B | 1 hits |
| 3 | NPHS1 | 1 hits |
| 4 | NPHS2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 32968210 | We showed that the expression levels of caspase-11 and cleavage of gasdermin D (GSDMD-N) in podocytes were significantly elevated, accompanied by reduced expression of podocyte makers nephrin and podocin, loss and fusion in podocyte foot processes, increased inflammatory cytokines NF-κB, IL-1β, and IL-18, macrophage infiltration, glomerular matrix expansion and increased urinary albumin to creatinine ratio (UACR). |
| 2 | 32968210 | Cultured human and mouse podocytes were treated with high glucose (30 mM), which significantly increased the expression levels of caspase-11 or caspase-4 (the homolog of caspase-11 in human), GSDMD-N, NF-κB, IL-1β, and IL-18, and decreased the expression of nephrin and podocin. |