Ignet

Gene Information

Gene symbol: CASP7

Gene name: caspase 7, apoptosis-related cysteine peptidase

HGNC ID: 1508

Synonyms: MCH3, CMH-1, ICE-LAP3

Related Genes

#	Gene Symbol	Number of hits
1	APAF1	1 hits
2	BAX	1 hits
3	BCL2	1 hits
4	CASP1	1 hits
5	CASP3	1 hits
6	CASP9	1 hits
7	E2F3	1 hits
8	IL18	1 hits
9	IL1B	1 hits
10	NLRP3	1 hits
11	PARP1	1 hits
12	PYCARD	1 hits
13	TIPARP	1 hits

Related Sentences

#	PMID	Sentence
1	26832955	Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy.
2	26832955	Here, we administered two partially disjunct polycaspase inhibitors in 8-week-old diabetic (db/db) mice: M-920 (inhibiting caspase-1, -3, -4, -5, -6, -7, and -8) and CIX (inhibiting caspase-3, -6, -7, -8, and -10).
3	26832955	Accordingly, analysis of gene expression data in the Nephromine database revealed persistently elevated glomerular expression of inflammasome markers (NLRP3, CASP1, PYCARD, IL-18, IL-1β), but not of apoptosis markers (CASP3, CASP7, PARP1), in patients with and murine models of dNP.
4	26832955	In vitro, increased levels of markers of inflammasome activation (Nlrp3, caspase-1 cleavage) preceded those of markers of apoptosis activation (caspase-3 and -7, PARP1 cleavage) in glucose-stressed podocytes.
5	26832955	Finally, caspase-3 deficiency did not protect mice from dNP, whereas both homozygous and hemizygous caspase-1 deficiency did.
6	26832955	Hence, these results suggest caspase-3-dependent cell death has a negligible effect, whereas caspase-1-dependent inflammasome activation has a crucial function in the establishment of dNP.
7	32696822	MicroRNA-770-5p contributes to podocyte injury via targeting E2F3 in diabetic nephropathy.
8	32696822	MicroRNA-770-5p depletion could repress high glucose (HG)-triggered apoptosis in podocytes, and downregulation of E2F transcription factor 3 (E2F3) could facilitate podocyte injury.
9	32696822	Nevertheless, whether E2F3 is involved in miR-770-5p knockdown-mediated improvement of DN is still unclear.
10	32696822	The expression levels of miR-770-5p and E2F3 were detected in HG-treated podocytes by RT-qPCR.
11	32696822	The expression levels of E2F3, apoptosis-related proteins Bcl-2 related X protein (Bax), B-cell lymphoma-2 (Bcl-2), Bad, apoptotic peptidase activating factor 1 (APAF1), C-caspase3, C-caspase7, and C-caspase9 were detected by western blot assay.
12	32696822	The effects of miR-770-5p and E2F3 on HG-treated podocytes proliferation and apoptosis were detected by CCK-8 and flow cytometry assays.
13	32696822	The interaction between miR-770-5p and E2F3 was predicted by Targetscan, and then verified by the dual-luciferase reporter assay.
14	32696822	MiR-770-5p was upregulated and E2F3 was downregulated in HG-treated podocytes.
15	32696822	MiR-770-5p inhibited proliferation and promoted apoptosis and E2F3 promoted proliferation and suppressed apoptosis in HG-treated podocytes.
16	32696822	E2F3 is a target gene of miR-770-5p and it partially abolished the effect of miR-770-5p in HG-triggered proliferation and apoptosis of podocytes.
17	32696822	MiR-770-5p deficiency blocked HG-induced APAF1/caspase9 pathway via targeting E2F3 in podocytes.
18	32696822	We firstly confirmed that E2F3 was a target of miR-770-5p in podocytes.
19	32696822	These findings suggested that miR-770-5p expedited podocyte injury by targeting E2F3, and the miR-770-5p/E2F3 axis might represent a pathological mechanism of DN progression.