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Gene Information
Gene symbol: CASR
Gene name: calcium-sensing receptor
HGNC ID: 1514
Synonyms: FHH, NSHPT, GPRC2A
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADD3 | 1 hits |
| 2 | AMMECR1 | 1 hits |
| 3 | CLDN14 | 1 hits |
| 4 | SHROOM3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 25273069 | The wild-type Shroom3 allele, but not the FHH Shroom3 allele, rescued glomerular defects induced by knockdown of endogenous shroom3 in zebrafish, suggesting that the FHH Shroom3 allele is defective and likely contributes to renal injury in the FHH rat. |
| 2 | 27878608 | In the glomerular podocytes, claudin-1 is an important determinant of cell junction fate. |
| 3 | 27878608 | More importantly, claudin-14 gene expression can be regulated by extracellular calcium levels via the calcium sensing receptor. |
| 4 | 27878608 | Aldosterone, WNK4, Cap1, and KLHL3 are powerful regulators of claudin and the paracellular chloride permeability. |
| 5 | 30104322 | Alport syndrome is a heritable chronic kidney disease where mutations in α3, α4, or α5 collagen genes promote podocyte death. |
| 6 | 30104322 | In this study, we assessed CaSR function in podocyte-like cells derived from induced-pluripotent stem cells from two patients with Alport Syndrome (AS1 & AS2) and a renal disease free individual [normal human mesangial cell (NHMC)], as well as a human immortalized podocyte-like (HIP) cell line. |
| 7 | 32830539 | The present study compared the time course of changes in renal hemodynamics and the progression of CKD during the development of DOCA-salt hypertension in FHH 1BN congenic rats [wild-type (WT)] with an intact myogenic response versus FHH 1BNAdd3KO (Add3KO) rats, which have impaired myogenic response. |
| 8 | 32830539 | After 1 wk of hypertension, glomerular filtration rate increased by 38% and glomerular nephrin expression decreased by 20% in Add3KO rats. |
| 9 | 33308016 | The present study explored whether Add3 contributes to the modulation of podocyte structure and function using FHH and FHH. |
| 10 | 33308016 | We found that F-actin nets, which are typically localized in the lamellipodia, replaced unbranched stress fibers in conditionally immortalized mouse podocytes transfected with Add3 Dicer-substrate short interfering RNA (DsiRNA) and primary podocytes isolated from FHH rats. |
| 11 | 33308016 | There were increased F/G-actin ratios and expression of the Arp2/3 complexes throughout FHH podocytes in association with reduced synaptopodin and RhoA but enhanced Rac1 and CDC42 expression in the renal cortex, glomeruli, and podocytes of FHH rats. |
| 12 | 33414130 | The present study evaluated the hypothesis that knockout (KO) of Add3 impairs the renal vasoconstrictor response to the blockade of nitric oxide synthase and enhances hypertension-induced renal injury after chronic administration of L-NAME plus a high-salt diet. |
| 13 | 33414130 | The acute hemodynamic effect of L-NAME and its chronic effects on hypertension and renal injury were compared in FHH 1Brown Norway (FHH 1BN) congenic rats (WT) expressing wild-type Add3 gene versus FHH 1BN Add3 KO rats. |
| 14 | 33414130 | Hypertensive Add3 KO rats exhibited greater loss of podocytes and glomerular nephrin expression and increased interstitial fibrosis than in WT rats. |