Ignet

Gene Information

Gene symbol: CD44

Gene name: CD44 molecule (Indian blood group)

HGNC ID: 1681

Synonyms: IN, MC56, Pgp1, CD44R, HCELL, CSPG8

Related Genes

#	Gene Symbol	Number of hits
1	ACE	1 hits
2	ACTC1	1 hits
3	ACTN4	1 hits
4	AIM2	1 hits
5	AKT3	1 hits
6	AR	1 hits
7	B4GALT1	1 hits
8	B4GALT7	1 hits
9	CASP3	1 hits
10	CD226	1 hits
11	CD2AP	1 hits
12	CD59	1 hits
13	CD74	1 hits
14	CLDN1	1 hits
15	CLDN7	1 hits
16	COL1A1	1 hits
17	COL4A4	1 hits
18	CSPG4	1 hits
19	CTGF	1 hits
20	CXCL12	1 hits
21	CXCR4	1 hits
22	DDR1	1 hits
23	DPEP1	1 hits
24	EGF	1 hits
25	EPHB2	1 hits
26	ERBB2	1 hits
27	FGF4	1 hits
28	GALM	1 hits
29	GPC5	1 hits
30	HGF	1 hits
31	HK2	1 hits
32	HSPG2	1 hits
33	ICAM1	1 hits
34	IL8RB	1 hits
35	ILK	1 hits
36	ITGAV	1 hits
37	ITGB1	1 hits
38	KRT19	1 hits
39	MAPK3	1 hits
40	MIF	1 hits
41	MKI67	1 hits
42	NES	1 hits
43	NID1	1 hits
44	NOTCH3	1 hits
45	NPHS2	1 hits
46	PDGFB	1 hits
47	PDGFRA	1 hits
48	PTPRO	1 hits
49	ROBO4	1 hits
50	RORC	1 hits
51	SYNPO	1 hits
52	TJP1	1 hits
53	VCAM1	1 hits
54	VEGFA	1 hits
55	VIM	1 hits
56	WT1	1 hits

Related Sentences

#	PMID	Sentence
1	34740957	In patients with glomerulonephritis, AIM2 expression increased in CD44⁺-activated parietal epithelial cells within glomerular crescents.
2	34740957	In patients with glomerulonephritis, AIM2 expression increased in CD44⁺-activated parietal epithelial cells within glomerular crescents.
3	34740957	Aim2 ^-/- mice also demonstrated dysregulated cellular proliferation and an increase in CD44⁺ parietal epithelial cells during glomerulonephritis.
4	34740957	Aim2 ^-/- mice also demonstrated dysregulated cellular proliferation and an increase in CD44⁺ parietal epithelial cells during glomerulonephritis.
5	34740957	The AIM2-like receptor (ALR) locus was necessary for the inflammatory glomerulonephritis phenotype observed in Aim2 ^-/- mice, as NTS-treated ALR ^-/- mice displayed equal levels of injury as wild-type controls.
6	34740957	The AIM2-like receptor (ALR) locus was necessary for the inflammatory glomerulonephritis phenotype observed in Aim2 ^-/- mice, as NTS-treated ALR ^-/- mice displayed equal levels of injury as wild-type controls.
7	33641441	For immunostaining, parietal epithelial cells facing the injured glomeruli of BXSB/MpJ-Yaa expressed CD44, an activated parietal epithelial cell marker, and CD44-positive parietal epithelial cells showed nuclear localization of the androgen receptor and proliferation marker Ki67.
8	33641441	For immunostaining, parietal epithelial cells facing the injured glomeruli of BXSB/MpJ-Yaa expressed CD44, an activated parietal epithelial cell marker, and CD44-positive parietal epithelial cells showed nuclear localization of the androgen receptor and proliferation marker Ki67.
9	33641441	CD44- or Ki67-positive parietal epithelial cells were significantly fewer in castrated group than in sham-operated BXSB/MpJ-Yaa at six months.
10	33641441	CD44- or Ki67-positive parietal epithelial cells were significantly fewer in castrated group than in sham-operated BXSB/MpJ-Yaa at six months.
11	33544806	The proliferated parietal cells of Bowman's capsule proved to express cluster of differentiation 44 (CD44), whereas remnant podocytes and mesangial cells showed Wilms tumor 1 (WT1) positivity.
12	33544806	The proliferated parietal cells of Bowman's capsule proved to express cluster of differentiation 44 (CD44), whereas remnant podocytes and mesangial cells showed Wilms tumor 1 (WT1) positivity.
13	33544806	Since CD44 might be involved in fibrogenesis, but ACE inhibitors can exert a protective role against glomerular deterioration, we performed a synthesis of literature data which enabled us to propose a hypothesis with a potential clinical impact.
14	33544806	Since CD44 might be involved in fibrogenesis, but ACE inhibitors can exert a protective role against glomerular deterioration, we performed a synthesis of literature data which enabled us to propose a hypothesis with a potential clinical impact.
15	33544806	We conclude that, in patients with LVAD implants, high blood pressure and high serum level of angiotensin II, the association between ACE inhibitors and anti-CD44 agents might exert glomerular protection and increase the survival time.
16	33544806	We conclude that, in patients with LVAD implants, high blood pressure and high serum level of angiotensin II, the association between ACE inhibitors and anti-CD44 agents might exert glomerular protection and increase the survival time.
17	32628542	Previously, we showed that FFSS-induced upregulation of the cyclooxygenase 2 (COX2)-PGE₂-prostaglandin E receptor 2 (EP2) axis in podocytes activates Akt-glycogen synthase kinase-3β-β-catenin and MAPK/ERK signaling in response to FFSS.
18	32628542	In the present study, we used previously characterized COX2 [prostaglandin-endoperoxide synthase 2 (Ptgs2)], EP2 (Ptger2), and β1-catenin (Ctnnb1) as "seed genes" from an array data set of four groups analyzed over a time course.
19	32628542	Further validation using Western blot analysis showed increased expression of phosho-Erbb2, phospho-mammalian target of rapamycin (mTOR), CD44, and hexokinase II (Hk2); decreased total Erbb2, galactose mutarotase (Galm), and β-1,4-galactosyltransferase 1 (B4galt1); and unchanged total mTOR and AKT3.
20	32597007	Vimentin and α-SMA, markers of changes to the epithelial cell phenotype, were present in PECs in aged CD44^+/+ mice, but absent in aged CD44^-/- mice in both outer cortical (OC) and juxtamedullary (JM) glomeruli.
21	32597007	Vimentin and α-SMA, markers of changes to the epithelial cell phenotype, were present in PECs in aged CD44^+/+ mice, but absent in aged CD44^-/- mice in both outer cortical (OC) and juxtamedullary (JM) glomeruli.
22	32597007	Vimentin and α-SMA, markers of changes to the epithelial cell phenotype, were present in PECs in aged CD44^+/+ mice, but absent in aged CD44^-/- mice in both outer cortical (OC) and juxtamedullary (JM) glomeruli.
23	32597007	Because age-related glomerular hypertrophy was lower in CD44^-/- mice, mTOR activation was assessed by phospho-S6 ribosomal protein (pS6RP) staining.
24	32597007	Because age-related glomerular hypertrophy was lower in CD44^-/- mice, mTOR activation was assessed by phospho-S6 ribosomal protein (pS6RP) staining.
25	32597007	Because age-related glomerular hypertrophy was lower in CD44^-/- mice, mTOR activation was assessed by phospho-S6 ribosomal protein (pS6RP) staining.
26	32597007	These results show that the increase in CD44 in PECs in aged kidneys contributes to several changes to the glomerulus during healthy aging in mice, and may involve ERK and mTOR activation.
27	32597007	These results show that the increase in CD44 in PECs in aged kidneys contributes to several changes to the glomerulus during healthy aging in mice, and may involve ERK and mTOR activation.
28	32597007	These results show that the increase in CD44 in PECs in aged kidneys contributes to several changes to the glomerulus during healthy aging in mice, and may involve ERK and mTOR activation.
29	32068458	Biphasic MIF and SDF1 expression during podocyte injury promote CD44-mediated glomerular parietal cell migration in focal segmental glomerulosclerosis.
30	32068458	Biphasic MIF and SDF1 expression during podocyte injury promote CD44-mediated glomerular parietal cell migration in focal segmental glomerulosclerosis.
31	32068458	Biphasic MIF and SDF1 expression during podocyte injury promote CD44-mediated glomerular parietal cell migration in focal segmental glomerulosclerosis.
32	32068458	Biphasic MIF and SDF1 expression during podocyte injury promote CD44-mediated glomerular parietal cell migration in focal segmental glomerulosclerosis.
33	32068458	Biphasic MIF and SDF1 expression during podocyte injury promote CD44-mediated glomerular parietal cell migration in focal segmental glomerulosclerosis.
34	32068458	Biphasic MIF and SDF1 expression during podocyte injury promote CD44-mediated glomerular parietal cell migration in focal segmental glomerulosclerosis.
35	32068458	The present study focused on CD44 signaling, particularly the roles of two CD44-related chemokines, migration inhibitory factor (MIF) and stromal cell-derived factor 1 (SDF1), and their common receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), in the NEP25/LMB2 mouse podocyte-toxin model of FSGS.
36	32068458	The present study focused on CD44 signaling, particularly the roles of two CD44-related chemokines, migration inhibitory factor (MIF) and stromal cell-derived factor 1 (SDF1), and their common receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), in the NEP25/LMB2 mouse podocyte-toxin model of FSGS.
37	32068458	The present study focused on CD44 signaling, particularly the roles of two CD44-related chemokines, migration inhibitory factor (MIF) and stromal cell-derived factor 1 (SDF1), and their common receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), in the NEP25/LMB2 mouse podocyte-toxin model of FSGS.
38	32068458	The present study focused on CD44 signaling, particularly the roles of two CD44-related chemokines, migration inhibitory factor (MIF) and stromal cell-derived factor 1 (SDF1), and their common receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), in the NEP25/LMB2 mouse podocyte-toxin model of FSGS.
39	32068458	The present study focused on CD44 signaling, particularly the roles of two CD44-related chemokines, migration inhibitory factor (MIF) and stromal cell-derived factor 1 (SDF1), and their common receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), in the NEP25/LMB2 mouse podocyte-toxin model of FSGS.
40	32068458	The present study focused on CD44 signaling, particularly the roles of two CD44-related chemokines, migration inhibitory factor (MIF) and stromal cell-derived factor 1 (SDF1), and their common receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), in the NEP25/LMB2 mouse podocyte-toxin model of FSGS.
41	32068458	Expression of MIF and SDF1 was first increased in injured podocytes and subsequently transferred to activated PECs expressing CD44 and CXCR4.
42	32068458	Expression of MIF and SDF1 was first increased in injured podocytes and subsequently transferred to activated PECs expressing CD44 and CXCR4.
43	32068458	Expression of MIF and SDF1 was first increased in injured podocytes and subsequently transferred to activated PECs expressing CD44 and CXCR4.
44	32068458	Expression of MIF and SDF1 was first increased in injured podocytes and subsequently transferred to activated PECs expressing CD44 and CXCR4.
45	32068458	Expression of MIF and SDF1 was first increased in injured podocytes and subsequently transferred to activated PECs expressing CD44 and CXCR4.
46	32068458	Expression of MIF and SDF1 was first increased in injured podocytes and subsequently transferred to activated PECs expressing CD44 and CXCR4.
47	32068458	In an immortalized mouse PEC (mPEC) line, recombinant MIF and SDF1 (rMIF and rSDF1, respectively) individually increased CD44 and CXCR4 mRNA and protein levels. rMIF and rSDF1 stimulated endogenous MIF and SDF1 production. rMIF- and rSDF1-induced mPEC migration was suppressed by CD44 siRNA.
48	32068458	In an immortalized mouse PEC (mPEC) line, recombinant MIF and SDF1 (rMIF and rSDF1, respectively) individually increased CD44 and CXCR4 mRNA and protein levels. rMIF and rSDF1 stimulated endogenous MIF and SDF1 production. rMIF- and rSDF1-induced mPEC migration was suppressed by CD44 siRNA.
49	32068458	In an immortalized mouse PEC (mPEC) line, recombinant MIF and SDF1 (rMIF and rSDF1, respectively) individually increased CD44 and CXCR4 mRNA and protein levels. rMIF and rSDF1 stimulated endogenous MIF and SDF1 production. rMIF- and rSDF1-induced mPEC migration was suppressed by CD44 siRNA.
50	32068458	In an immortalized mouse PEC (mPEC) line, recombinant MIF and SDF1 (rMIF and rSDF1, respectively) individually increased CD44 and CXCR4 mRNA and protein levels. rMIF and rSDF1 stimulated endogenous MIF and SDF1 production. rMIF- and rSDF1-induced mPEC migration was suppressed by CD44 siRNA.
51	32068458	In an immortalized mouse PEC (mPEC) line, recombinant MIF and SDF1 (rMIF and rSDF1, respectively) individually increased CD44 and CXCR4 mRNA and protein levels. rMIF and rSDF1 stimulated endogenous MIF and SDF1 production. rMIF- and rSDF1-induced mPEC migration was suppressed by CD44 siRNA.
52	32068458	In an immortalized mouse PEC (mPEC) line, recombinant MIF and SDF1 (rMIF and rSDF1, respectively) individually increased CD44 and CXCR4 mRNA and protein levels. rMIF and rSDF1 stimulated endogenous MIF and SDF1 production. rMIF- and rSDF1-induced mPEC migration was suppressed by CD44 siRNA.
53	32068458	However, MIF and SDF1 inhibitors failed to show any impact on proteinuria, podocyte number, and CD44 expression in NEP25/LMB2 mice.
54	32068458	However, MIF and SDF1 inhibitors failed to show any impact on proteinuria, podocyte number, and CD44 expression in NEP25/LMB2 mice.
55	32068458	However, MIF and SDF1 inhibitors failed to show any impact on proteinuria, podocyte number, and CD44 expression in NEP25/LMB2 mice.
56	32068458	However, MIF and SDF1 inhibitors failed to show any impact on proteinuria, podocyte number, and CD44 expression in NEP25/LMB2 mice.
57	32068458	However, MIF and SDF1 inhibitors failed to show any impact on proteinuria, podocyte number, and CD44 expression in NEP25/LMB2 mice.
58	32068458	However, MIF and SDF1 inhibitors failed to show any impact on proteinuria, podocyte number, and CD44 expression in NEP25/LMB2 mice.
59	32068458	Our data suggest that injured podocytes upregulate MIF and SDF1 that stimulate CD44 expression and CD44-mediated migration, which is enhanced by endogenous MIF and SDF1 in PECs.
60	32068458	Our data suggest that injured podocytes upregulate MIF and SDF1 that stimulate CD44 expression and CD44-mediated migration, which is enhanced by endogenous MIF and SDF1 in PECs.
61	32068458	Our data suggest that injured podocytes upregulate MIF and SDF1 that stimulate CD44 expression and CD44-mediated migration, which is enhanced by endogenous MIF and SDF1 in PECs.
62	32068458	Our data suggest that injured podocytes upregulate MIF and SDF1 that stimulate CD44 expression and CD44-mediated migration, which is enhanced by endogenous MIF and SDF1 in PECs.
63	32068458	Our data suggest that injured podocytes upregulate MIF and SDF1 that stimulate CD44 expression and CD44-mediated migration, which is enhanced by endogenous MIF and SDF1 in PECs.
64	32068458	Our data suggest that injured podocytes upregulate MIF and SDF1 that stimulate CD44 expression and CD44-mediated migration, which is enhanced by endogenous MIF and SDF1 in PECs.
65	31630546	In healthy glomeruli, parietal epithelial cell (PEC)-derived extracellular matrix (ECM) proteins include laminin-β₁, perlecan, and collagen type IV-α₂ and podocyte-specific ECM proteins include laminin-β₂, agrin, and collagen type IV-α₄.
66	31630546	In healthy glomeruli, parietal epithelial cell (PEC)-derived extracellular matrix (ECM) proteins include laminin-β₁, perlecan, and collagen type IV-α₂ and podocyte-specific ECM proteins include laminin-β₂, agrin, and collagen type IV-α₄.
67	31630546	To determine the role of CD44, FSGS was induced in CD44^-/- and CD44^+/+ mice.
68	31630546	To determine the role of CD44, FSGS was induced in CD44^-/- and CD44^+/+ mice.
69	31630546	PEC staining for perlecan, collagen type IV-α₂, laminin-β₂, and agrin were significantly lower in diseased CD44^-/- mice compared with diseased CD44^+/+ mice.
70	31630546	PEC staining for perlecan, collagen type IV-α₂, laminin-β₂, and agrin were significantly lower in diseased CD44^-/- mice compared with diseased CD44^+/+ mice.
71	30285525	Focal and segmental glomerulosclerosis in murine models: a histological and ultrastructural characterization with immunohistochemistry correlation of glomerular CD44 and WT1 expression.
72	29673759	Like all basement membranes, the GBM contains type IV collagen, laminin, nidogen, and heparan sulfate proteoglycan.
73	29673759	Mutations that affect the GBM's collagen α3α4α5(IV) components cause Alport syndrome (kidney disease with variable ear and eye defects) and its variants, including thin basement membrane nephropathy.
74	29673759	The very different types of kidney diseases that result from mutations in collagen IV vs. laminin are likely due to very different pathogenic mechanisms.
75	27998643	Activated ERK1/2 increases CD44 in glomerular parietal epithelial cells leading to matrix expansion.
76	27998643	Activated ERK1/2 increases CD44 in glomerular parietal epithelial cells leading to matrix expansion.
77	27998643	Activated ERK1/2 increases CD44 in glomerular parietal epithelial cells leading to matrix expansion.
78	27998643	Activated ERK1/2 increases CD44 in glomerular parietal epithelial cells leading to matrix expansion.
79	27998643	Albuminuria, focal and global glomerulosclerosis (periodic acid-Schiff stain), and collagen IV staining were lower in CD44 knockout compared with wild-type mice with FSGS.
80	27998643	Albuminuria, focal and global glomerulosclerosis (periodic acid-Schiff stain), and collagen IV staining were lower in CD44 knockout compared with wild-type mice with FSGS.
81	27998643	Albuminuria, focal and global glomerulosclerosis (periodic acid-Schiff stain), and collagen IV staining were lower in CD44 knockout compared with wild-type mice with FSGS.
82	27998643	Albuminuria, focal and global glomerulosclerosis (periodic acid-Schiff stain), and collagen IV staining were lower in CD44 knockout compared with wild-type mice with FSGS.
83	27998643	In cultured murine parietal epithelial cells, overexpressing CD44 with a retroviral vector encoding CD44 was accompanied by significantly increased collagen IV expression and parietal epithelial cell migration.
84	27998643	In cultured murine parietal epithelial cells, overexpressing CD44 with a retroviral vector encoding CD44 was accompanied by significantly increased collagen IV expression and parietal epithelial cell migration.
85	27998643	In cultured murine parietal epithelial cells, overexpressing CD44 with a retroviral vector encoding CD44 was accompanied by significantly increased collagen IV expression and parietal epithelial cell migration.
86	27998643	In cultured murine parietal epithelial cells, overexpressing CD44 with a retroviral vector encoding CD44 was accompanied by significantly increased collagen IV expression and parietal epithelial cell migration.
87	27998643	Because our results showed de novo co-staining for activated ERK1/2 (pERK) in parietal epithelial cells in experimental FSGS, and also in biopsies from patients with FSGS, two in vitro strategies were employed to prove that pERK regulated CD44 levels.
88	27998643	Because our results showed de novo co-staining for activated ERK1/2 (pERK) in parietal epithelial cells in experimental FSGS, and also in biopsies from patients with FSGS, two in vitro strategies were employed to prove that pERK regulated CD44 levels.
89	27998643	Because our results showed de novo co-staining for activated ERK1/2 (pERK) in parietal epithelial cells in experimental FSGS, and also in biopsies from patients with FSGS, two in vitro strategies were employed to prove that pERK regulated CD44 levels.
90	27998643	Because our results showed de novo co-staining for activated ERK1/2 (pERK) in parietal epithelial cells in experimental FSGS, and also in biopsies from patients with FSGS, two in vitro strategies were employed to prove that pERK regulated CD44 levels.
91	27440779	Additionally, markers of epithelial-to-mesenchymal transition (platelet-derived growth factor receptor-β, α-smooth muscle actin, Notch-3) and PEC activation (CD44, collagen IV) were further increased by mTOR reduction.
92	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
93	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
94	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
95	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
96	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
97	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
98	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
99	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
100	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
101	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
102	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
103	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
104	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
105	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
106	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
107	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
108	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
109	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
110	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
111	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
112	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
113	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
114	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
115	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
116	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
117	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
118	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
119	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
120	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
121	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
122	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
123	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
124	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
125	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
126	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
127	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
128	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
129	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
130	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
131	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
132	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
133	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
134	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
135	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
136	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
137	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
138	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
139	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
140	26403399	In addition, vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF) and cluster of differentiation (CD) 44 were observed by Masson staining and detected with immunohistochemistry (IHC) to confirm homing and location of mesenchymal stem cells (MSCs).
141	26403399	Moreover, Western Blot was used for detecting VEGF and CTGF so as to explore the possible mechanism of applying UMSC in treating IgAN.
142	26403399	MSCs were observed to be located in glomerulus and renal interstitium by IHC detection of CD44 and IHC qualitative observation of VEGF and CTGF had different positive expressions in three groups.
143	26403399	Furthermore, different expressions of VEGF and CTGF were observed quantitatively by Western Blot.
144	26260163	Hereditary angiopathy, nephropathy, aneurysms, and muscle cramps (HANAC) syndrome is an autosomal dominant syndrome caused by mutations in COL4A1 that encodes the α1 chain of collagen IV, a major component of basement membranes.
145	26260163	Abnormal structure of Bowman's capsule was associated with metalloproteinase induction and activation of the glomerular parietal epithelial cells that abnormally expressed CD44,α-SMA, ILK, and DDR1.
146	26260163	These results reveal a developmental role for the α1α1α2 collagen IV molecule in the embryonic glomerular basement membrane, affecting podocyte differentiation.
147	26017974	In addition to segmental and global glomerulosclerosis in older mice, staining for matrix proteins collagen type IV and heparan sulfate proteoglycan were markedly increased in Bowman's capsules of older mouse glomeruli, consistent with increased extracellular matrix production by PECs.
148	26017974	The mural cell markers neural/glial antigen 2, PDGF receptor-β, and CD146 as well as Notch 3 were also substantially increased in aged PECs.
149	25987249	We recently identified the gene for glypican-5 (GPC5), a cell-surface heparan sulfate proteoglycan, as conferring susceptibility for acquired nephrotic syndrome and additionally identified an association through a genome-wide association study between a variant in GPC5 and DN of type 2 diabetes mellitus.
150	25987249	In this study, diabetic kidney showed that accumulation of fibroblast growth factor (Fgf)2 strikingly induced progressive proteinuria that was avoided in Gpc5 knockdown mice.
151	25987249	Extraglomerular Fgf2 was pathogenic in DN, and the deterrence of Gpc5 effectively inhibited the glomerular accumulation of Fgf2, the subsequent increase of mesangial extracellular matrix, and the podocytes' small GTPase activity.
152	25853334	For each biopsy, one section was quadruple stained for PECs (ANXA3), podocytes (synaptopodin), PEC matrix (LKIV69), and Hoechst (nuclei), and a second was quadruple stained for activated PECs (CD44 and cytokeratin-19), PEC matrix, and nuclei.
153	25736496	These isolated Nestin(+) cells expressed the typical cell-surface marker of MSC, including Sca-1, CD44, CD106, NG2 and PDGFR-α.
154	25307344	Ninety-five renal biopsies were stained for claudin-1 (PEC marker), CD44 (activated PECs), and LKIV69 (PEC matrix); 38 had been diagnosed as early primary FSGS and 57 as minimal change disease.
155	25307344	Two novel PEC markers A-kinase anchor protein 12 and annexin A3 exhibited similar sensitivity.
156	24790760	CD59, CD44, IBP7, Robo4, and DPEP1 were the most significant differentially expressed proteins.
157	23826724	CD44 is a transmembrane adhesion glycoprotein, functioning as a hyaluronan receptor and participating in the uptake and degradation of hyaluronan.
158	21519194	The main components of the GBM are laminin-521 (α5β2γ1), collagen α3α4α5(IV), nidogen and the heparan sulfate proteoglycan, agrin.
159	21519194	In contrast, mutations that affect GBM collagen IV or agrin do not impair glomerular development or cause immediate leakage of plasma proteins.
160	21519194	However, collagen IV mutation, which causes Alport syndrome and ESRD in humans, leads to gradual damage to the GBM that eventually leads to albuminuria and renal failure.
161	20031026	This study demonstrates that the expression of the mesenchymal markers CD29 and CD44, the epithelial markers CD51 and ZO-1 and the podocyte markers CD2AP and NPHS2 can be induced in these cells via incubation with epidermal growth factor/platelet-derived growth factor BB and fibroblast growth factor 4/hepatocyte growth factor, respectively.
162	15258770	ICAM-1 and CD44, the ligation of which induces migratory behaviors, were absent from healthy podocytes but expressed by some podocytes in glomerulonephritis.
163	10500175	The mRNA expression of glomerular epithelial protein 1 (a marker for renal podocytes), anti-heparan-sulfate-proteoglycan antibody reactivity, and wheat germ agglutinin lectin staining of the metanephros were unaffected.
164	6235751	Localization of collagen types IV and V, laminin, and heparan sulfate proteoglycan to the basal lamina of kidney epithelial cells in transfilter metanephric culture.