Ignet

Gene Information

Gene symbol: CD74

Gene name: CD74 molecule, major histocompatibility complex, class II invariant chain

HGNC ID: 1697

Related Genes

#	Gene Symbol	Number of hits
1	B2M	1 hits
2	CD44	1 hits
3	CXCR4	1 hits
4	DCT	1 hits
5	DDT	1 hits
6	FXYD5	1 hits
7	HLA-A	1 hits
8	HLA-DPA1	1 hits
9	IL8RB	1 hits
10	MAPK14	1 hits
11	MAPK3	1 hits
12	MAPK6	1 hits
13	MIF	1 hits
14	TNF	1 hits
15	TNFSF10	1 hits

Related Sentences

#	PMID	Sentence
1	2482595	We have analysed the expression of MHC class I and II antigens including the associated invariant gamma-chain in 100 consecutive renal biopsies by a sensitive immunoperoxidase method using monoclonal antibodies against HLA-ABC, HLA-DR, HLA-DQ, HLA-DP and the invariant gamma-chain (Ii).
2	18842989	The MIF receptor CD74 in diabetic podocyte injury.
3	18842989	Expression of macrophage migration inhibitory factor (MIF) is increased in experimental diabetic nephropathy, and increased tubulointerstitial mRNA expression of its receptor, CD74, has been observed in human diabetic nephropathy.
4	18842989	Whether CD74 transduces MIF signals in podocytes, however, is unknown.
5	18842989	In cultured human podocytes, CD74 was expressed at the cell surface, was upregulated by high concentrations of glucose and TNF-alpha, and was activated by MIF, leading to phosphorylation of extracellular signal-regulated kinase 1/2 and p38.
6	18842989	In addition, MIF induced the expression of the inflammatory mediators TRAIL and monocyte chemoattractant protein 1 in podocytes and HK2 cells in a p38-dependent manner.
7	18842989	These data suggest that CD74 acts as a receptor for MIF in podocytes and may play a role in the pathogenesis of diabetic nephropathy.
8	18842989	The MIF receptor CD74 in diabetic podocyte injury.
9	18842989	Expression of macrophage migration inhibitory factor (MIF) is increased in experimental diabetic nephropathy, and increased tubulointerstitial mRNA expression of its receptor, CD74, has been observed in human diabetic nephropathy.
10	18842989	Whether CD74 transduces MIF signals in podocytes, however, is unknown.
11	18842989	In cultured human podocytes, CD74 was expressed at the cell surface, was upregulated by high concentrations of glucose and TNF-alpha, and was activated by MIF, leading to phosphorylation of extracellular signal-regulated kinase 1/2 and p38.
12	18842989	In addition, MIF induced the expression of the inflammatory mediators TRAIL and monocyte chemoattractant protein 1 in podocytes and HK2 cells in a p38-dependent manner.
13	18842989	These data suggest that CD74 acts as a receptor for MIF in podocytes and may play a role in the pathogenesis of diabetic nephropathy.
14	18842989	The MIF receptor CD74 in diabetic podocyte injury.
15	18842989	Expression of macrophage migration inhibitory factor (MIF) is increased in experimental diabetic nephropathy, and increased tubulointerstitial mRNA expression of its receptor, CD74, has been observed in human diabetic nephropathy.
16	18842989	Whether CD74 transduces MIF signals in podocytes, however, is unknown.
17	18842989	In cultured human podocytes, CD74 was expressed at the cell surface, was upregulated by high concentrations of glucose and TNF-alpha, and was activated by MIF, leading to phosphorylation of extracellular signal-regulated kinase 1/2 and p38.
18	18842989	In addition, MIF induced the expression of the inflammatory mediators TRAIL and monocyte chemoattractant protein 1 in podocytes and HK2 cells in a p38-dependent manner.
19	18842989	These data suggest that CD74 acts as a receptor for MIF in podocytes and may play a role in the pathogenesis of diabetic nephropathy.
20	18842989	The MIF receptor CD74 in diabetic podocyte injury.
21	18842989	Expression of macrophage migration inhibitory factor (MIF) is increased in experimental diabetic nephropathy, and increased tubulointerstitial mRNA expression of its receptor, CD74, has been observed in human diabetic nephropathy.
22	18842989	Whether CD74 transduces MIF signals in podocytes, however, is unknown.
23	18842989	In cultured human podocytes, CD74 was expressed at the cell surface, was upregulated by high concentrations of glucose and TNF-alpha, and was activated by MIF, leading to phosphorylation of extracellular signal-regulated kinase 1/2 and p38.
24	18842989	In addition, MIF induced the expression of the inflammatory mediators TRAIL and monocyte chemoattractant protein 1 in podocytes and HK2 cells in a p38-dependent manner.
25	18842989	These data suggest that CD74 acts as a receptor for MIF in podocytes and may play a role in the pathogenesis of diabetic nephropathy.
26	18842989	The MIF receptor CD74 in diabetic podocyte injury.
27	18842989	Expression of macrophage migration inhibitory factor (MIF) is increased in experimental diabetic nephropathy, and increased tubulointerstitial mRNA expression of its receptor, CD74, has been observed in human diabetic nephropathy.
28	18842989	Whether CD74 transduces MIF signals in podocytes, however, is unknown.
29	18842989	In cultured human podocytes, CD74 was expressed at the cell surface, was upregulated by high concentrations of glucose and TNF-alpha, and was activated by MIF, leading to phosphorylation of extracellular signal-regulated kinase 1/2 and p38.
30	18842989	In addition, MIF induced the expression of the inflammatory mediators TRAIL and monocyte chemoattractant protein 1 in podocytes and HK2 cells in a p38-dependent manner.
31	18842989	These data suggest that CD74 acts as a receptor for MIF in podocytes and may play a role in the pathogenesis of diabetic nephropathy.
32	19240767	TNF-related apoptosisinducing ligand (TRAIL) and osteoprotegerin had the highest level of expression.
33	19240767	Inflammatory cytokines, including MIF via CD74, upregulate TRAIL.
34	26441987	CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT/MIF-2).
35	26441987	MIF activates CD74 to increase inflammatory cytokines in podocytes and tubular cells and proliferation in glomerular parietal epithelial cells and cyst cells.
36	26441987	MIF overexpression promotes while MIF targeting protects from experimental glomerular injury and kidney cysts, and interference with MIF/CD74 signaling or CD74 deficiency protected from crescentic glomerulonephritis.
37	26441987	CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT/MIF-2).
38	26441987	MIF activates CD74 to increase inflammatory cytokines in podocytes and tubular cells and proliferation in glomerular parietal epithelial cells and cyst cells.
39	26441987	MIF overexpression promotes while MIF targeting protects from experimental glomerular injury and kidney cysts, and interference with MIF/CD74 signaling or CD74 deficiency protected from crescentic glomerulonephritis.
40	26441987	CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT/MIF-2).
41	26441987	MIF activates CD74 to increase inflammatory cytokines in podocytes and tubular cells and proliferation in glomerular parietal epithelial cells and cyst cells.
42	26441987	MIF overexpression promotes while MIF targeting protects from experimental glomerular injury and kidney cysts, and interference with MIF/CD74 signaling or CD74 deficiency protected from crescentic glomerulonephritis.
43	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
44	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
45	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
46	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
47	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
48	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
49	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
50	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
51	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
52	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
53	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
54	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
55	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
56	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
57	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
58	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
59	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
60	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
61	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
62	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
63	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
64	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
65	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
66	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
67	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
68	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
69	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
70	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
71	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
72	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
73	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
74	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
75	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
76	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
77	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
78	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
79	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
80	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
81	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
82	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
83	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
84	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
85	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
86	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
87	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
88	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
89	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
90	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
91	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
92	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
93	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
94	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
95	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
96	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
97	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
98	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
99	26453615	Macrophage Migration Inhibitory Factor Mediates Proliferative GN via CD74.
100	26453615	Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4.
101	26453615	The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.
102	26453615	Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides.
103	26453615	MIF, CD74, and CD44 were upregulated in the glomeruli of patients and mice with proliferative glomerulonephritides.
104	26453615	During disease, CD74 and CD44 were expressed de novo in PECs and colocalized in both PECs and mesangial cells.
105	26453615	Stress stimuli induced MIF secretion from glomerular cells in vitro and in vivo, in particular from podocytes, and MIF stimulation induced proliferation of PECs and mesangial cells via CD74.
106	26453615	Our data suggest a novel molecular mechanism and glomerular cell crosstalk by which local upregulation of MIF and its receptor complex CD74/CD44 mediate glomerular injury and pathologic proliferation in GN.
107	29952416	MIF/CD74 axis is a target for metformin therapy in diabetic podocytopathy - real world evidence.
108	29952416	Introduction：To observe the effects of metformin on urinary excretion of MIF, CD74 and podocalyxin in type 2 diabetics and to explore its possible renoprotective mechanisms.
109	29952416	MIF/CD74 axis is a target for metformin therapy in diabetic podocytopathy - real world evidence.
110	29952416	Introduction：To observe the effects of metformin on urinary excretion of MIF, CD74 and podocalyxin in type 2 diabetics and to explore its possible renoprotective mechanisms.
111	33754492	Furthermore, in the cluster of the podocyte, three glomerulonephritis related genes named FXYD5, CD74 and B2M were found.
112	33754492	Compared with the mesangial of donor, the gene CLIC1 and RPS26 were up-regulated in mesangial of IgA nephropathy(IgAN), whereas the gene JUNB was up-regulated in podocyte of IgAN in comparison with that of donor.
113	33754492	Meanwhile, some membranous nephropathy (MN) high expressed genes such as HLA-DRB5, HLA-DQA2, IFNG, CCL2 and NR4A2, which involve in highest enrichment pathway, display the cellular-specific expression style, whereas monocyte marker of lupus nephritis (LN) named TNFSF13B was also found and interferon alpha/beta signalling pathway was enriched in B and NKT of LN comparing with donor.