Ignet

Gene Information

Gene symbol: CDH5

Gene name: cadherin 5, type 2 (vascular endothelium)

HGNC ID: 1764

Synonyms: 7B4, CD144

Related Genes

#	Gene Symbol	Number of hits
1	FLT4	1 hits
2	KDR	1 hits
3	MYH14	1 hits
4	MYL2	1 hits
5	NPHS1	1 hits
6	NPHS2	1 hits
7	PECAM1	1 hits
8	TJP1	1 hits
9	VEGFC	1 hits

Related Sentences

#	PMID	Sentence
1	16581909	Phylogenetic promoter fingerprints of known elements of the slit diaphragm complex identified the nephrin model in the promoter region of zonula occludens-1 (ZO-1).
2	16581909	Nephrin, ZO-1, and cadherin-5 mRNA showed stringent coexpression across a diverse set of human glomerular diseases.
3	18772335	We have previously reported expression of vascular endothelial growth factor (VEGF)-A and -C in glomerular podocytes and actions of VEGF-A on glomerular endothelial cells (GEnC) that express VEGF receptor-2 (VEGFR-2).
4	18772335	Here we define VEGFR-3 expression in GEnC and investigate the effects of the ligand VEGF-C.
5	18772335	VEGF-C effects on trans-endothelial electrical resistance and albumin flux across GEnC monolayers were measured.
6	18772335	VEGF-C effects on intracellular calcium ([Ca2+]i) were measured using a fluorescence technique, receptor phosphorylation was examined by immunoprecipitation assays, and phosphorylation of myosin light chain-2 and VE-cadherin was assessed by blotting with phospho-specific antibodies.
7	18772335	GEnC expressed VEGFR-3 in tissue sections and culture, and VEGF-C increased trans-endothelial electrical resistance in a dose-dependent manner with a maximal effect at 120 minutes of 6.8 Omega whereas VEGF-C156S had no effect.
8	18772335	VEGF-C reduced labeled albumin flux by 32.8%.
9	18772335	VEGF-C and VEGF-A increased [Ca2+]i by 15% and 39%, respectively.
10	18772335	VEGF-C phosphorylated VEGFR-2 but not VEGFR-3, myosin light chain-2, or VE-cadherin.
11	18772335	These observations suggest that podocytes direct GEnC behavior through both VEGF-C and VEGF-A.
12	18772335	We have previously reported expression of vascular endothelial growth factor (VEGF)-A and -C in glomerular podocytes and actions of VEGF-A on glomerular endothelial cells (GEnC) that express VEGF receptor-2 (VEGFR-2).
13	18772335	Here we define VEGFR-3 expression in GEnC and investigate the effects of the ligand VEGF-C.
14	18772335	VEGF-C effects on trans-endothelial electrical resistance and albumin flux across GEnC monolayers were measured.
15	18772335	VEGF-C effects on intracellular calcium ([Ca2+]i) were measured using a fluorescence technique, receptor phosphorylation was examined by immunoprecipitation assays, and phosphorylation of myosin light chain-2 and VE-cadherin was assessed by blotting with phospho-specific antibodies.
16	18772335	GEnC expressed VEGFR-3 in tissue sections and culture, and VEGF-C increased trans-endothelial electrical resistance in a dose-dependent manner with a maximal effect at 120 minutes of 6.8 Omega whereas VEGF-C156S had no effect.
17	18772335	VEGF-C reduced labeled albumin flux by 32.8%.
18	18772335	VEGF-C and VEGF-A increased [Ca2+]i by 15% and 39%, respectively.
19	18772335	VEGF-C phosphorylated VEGFR-2 but not VEGFR-3, myosin light chain-2, or VE-cadherin.
20	18772335	These observations suggest that podocytes direct GEnC behavior through both VEGF-C and VEGF-A.
21	21653636	Western blot and immunofluorescence analysis showed that podocyte markers (nephrin, CD2AP, podocin, Wilms' tumor-1) and an endothelial-specific molecule (VE-cadherin) were not detectable in this cell line, whereas markers characteristic of mesangial cells (α-SMA, fibronectin, and PDGFβ-R) were strongly expressed.
22	25859060	We previously provided evidence that an apparent decrease in nephrin, caused by tensin2-deficiencient states, leads to podocytopathy, albuminuria and eventually, chronic renal failure.
23	25859060	Herein, we examined the changes of glomerular ECs, with focus on the expression of PECAM-1 and VE-cadherin (EC-specific markers), or of α-SMA (myofibroblast marker) in this mouse model by histological methods.
24	25859060	Compared with the non-nephrotic (+/nep) mice, the nephrotic (nep/nep) mice exhibited the reduced expression of PECAM-1, or of VE-cadherin, in glomerular area.
25	25859060	We previously provided evidence that an apparent decrease in nephrin, caused by tensin2-deficiencient states, leads to podocytopathy, albuminuria and eventually, chronic renal failure.
26	25859060	Herein, we examined the changes of glomerular ECs, with focus on the expression of PECAM-1 and VE-cadherin (EC-specific markers), or of α-SMA (myofibroblast marker) in this mouse model by histological methods.
27	25859060	Compared with the non-nephrotic (+/nep) mice, the nephrotic (nep/nep) mice exhibited the reduced expression of PECAM-1, or of VE-cadherin, in glomerular area.