Ignet

Gene Information

Gene symbol: CLCN5

Gene name: chloride channel, voltage-sensitive 5

HGNC ID: 2023

Synonyms: DENTS, XLRH, hClC-K2, hCIC-K2, CLC5, XRN, ClC-5

Related Genes

#	Gene Symbol	Number of hits
1	ALB	1 hits
2	CUBN	1 hits
3	GAPDH	1 hits
4	LRP2	1 hits
5	NPHS2	1 hits

Related Sentences

#	PMID	Sentence
1	29057905	Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex.
2	29057905	We show that these cells express cubilin, megalin, ClC-5, amnionless and Dab2, which are partners in the tubular machinery.
3	29057905	Exposing human podocytes to albumin overload prompted an increase in CUBILIN, AMNIONLESS and CLCN5 gene expression.
4	29057905	Inhibiting cubilin led to a reduction in albumin uptake, highlighting its importance in this mechanism.
5	29057905	We also disclosed that protein overload first acts on the expression of the cubilin-amnionless (CUBAM) complex in these cells, then involves the ClC-5 channel, providing the first evidence for a possible role of the CUBAM complex in albumin endocytosis in human podocytes.
6	29057905	Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex.
7	29057905	We show that these cells express cubilin, megalin, ClC-5, amnionless and Dab2, which are partners in the tubular machinery.
8	29057905	Exposing human podocytes to albumin overload prompted an increase in CUBILIN, AMNIONLESS and CLCN5 gene expression.
9	29057905	Inhibiting cubilin led to a reduction in albumin uptake, highlighting its importance in this mechanism.
10	29057905	We also disclosed that protein overload first acts on the expression of the cubilin-amnionless (CUBAM) complex in these cells, then involves the ClC-5 channel, providing the first evidence for a possible role of the CUBAM complex in albumin endocytosis in human podocytes.
11	29057905	Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex.
12	29057905	We show that these cells express cubilin, megalin, ClC-5, amnionless and Dab2, which are partners in the tubular machinery.
13	29057905	Exposing human podocytes to albumin overload prompted an increase in CUBILIN, AMNIONLESS and CLCN5 gene expression.
14	29057905	Inhibiting cubilin led to a reduction in albumin uptake, highlighting its importance in this mechanism.
15	29057905	We also disclosed that protein overload first acts on the expression of the cubilin-amnionless (CUBAM) complex in these cells, then involves the ClC-5 channel, providing the first evidence for a possible role of the CUBAM complex in albumin endocytosis in human podocytes.
16	32019767	ClC-5, the electrogenic chloride/proton exchanger strongly expressed in renal proximal tubules, belongs to the endocytic macromolecular complex responsible for albumin and low-molecular-weight protein uptake.
17	32019767	ClC-5 was found to be overexpressed in glomeruli of glomerulonephritis and in cultured human podocytes under albumin overload.
18	32019767	The 5'UTR ends and the translated region of CLCN5 mRNA were analyzed using quantitative relative real-time PCR or quantitative comparative endpoint PCR with GAPDH as housekeeping gene in 8 normal kidneys and 12 renal biopsies from patients with glomerulonephritis.
19	32019767	ClC-5, the electrogenic chloride/proton exchanger strongly expressed in renal proximal tubules, belongs to the endocytic macromolecular complex responsible for albumin and low-molecular-weight protein uptake.
20	32019767	ClC-5 was found to be overexpressed in glomeruli of glomerulonephritis and in cultured human podocytes under albumin overload.
21	32019767	The 5'UTR ends and the translated region of CLCN5 mRNA were analyzed using quantitative relative real-time PCR or quantitative comparative endpoint PCR with GAPDH as housekeeping gene in 8 normal kidneys and 12 renal biopsies from patients with glomerulonephritis.
22	32019767	ClC-5, the electrogenic chloride/proton exchanger strongly expressed in renal proximal tubules, belongs to the endocytic macromolecular complex responsible for albumin and low-molecular-weight protein uptake.
23	32019767	ClC-5 was found to be overexpressed in glomeruli of glomerulonephritis and in cultured human podocytes under albumin overload.
24	32019767	The 5'UTR ends and the translated region of CLCN5 mRNA were analyzed using quantitative relative real-time PCR or quantitative comparative endpoint PCR with GAPDH as housekeeping gene in 8 normal kidneys and 12 renal biopsies from patients with glomerulonephritis.
25	32840752	Downregulation of megalin, cubilin, ClC-5 and podocin in Fabry nephropathy: potential implications in the decreased effectiveness of enzyme replacement therapy.
26	32840752	We report in a male and a female patient the decreased expression of megalin, cubilin, ClC-5 and podocin compared to controls and chronic kidney disease (CKD) biopsies.
27	32840752	Downregulation of megalin, cubilin, ClC-5 and podocin in Fabry nephropathy: potential implications in the decreased effectiveness of enzyme replacement therapy.
28	32840752	We report in a male and a female patient the decreased expression of megalin, cubilin, ClC-5 and podocin compared to controls and chronic kidney disease (CKD) biopsies.