About

Home

Introduction

Statistics

Programs

Dignet

Gene

GenePair

BioSummarAI

Help & Docs

Documents

Help

FAQs

Links

Acknowledge

Disclaimer

Contact Us

Gene Information

Gene symbol: CRB2

Gene name: crumbs homolog 2 (Drosophila)

HGNC ID: 18688

Synonyms: FLJ38464, FLJ16786

Related Genes

#	Gene Symbol	Number of hits
1	AFP	1 hits
2	CRB3	1 hits
3	JPH4	1 hits
4	NPHS1	1 hits
5	NPHS2	1 hits
6	PODXL	1 hits

Related Sentences

#	PMID	Sentence
1	25557780	CRB2 mutations produce a phenotype resembling congenital nephrosis, Finnish type, with cerebral ventriculomegaly and raised alpha-fetoprotein.
2	28612137	The Crumbs complex including the integral membrane protein Crumbs, as well as Pals1 and Patj, is essential for the establishment of apicobasal polarity.
3	28612137	Notably, Crb2 and Crb3 are expressed within the kidney and play an important role in the proper function of podocytes and tubules, respectively.
4	28717874	Nephrocyte-specific knock-down of Crumbs results in disturbed nephrocyte diaphragm assembly/maintenance and decreased endocytosis, which can be rescued by Drosophila Crumbs as well as human Crumbs2 and Crumbs3, which were both expressed in human podocytes.
5	30125302	Because another isoform, CRB3, was reported to repress the mechanistic/mammalian target of the rapamycin complex 1 (mTORC1) pathway, we examined the role of CRB2 function in developing podocytes in relation to mTORC1.
6	34654837	Crb2 is a cell polarity-related type I transmembrane protein expressed in the apical membrane of podocytes.
7	34654837	The number of glomerular Wt1-positive cells and the expressions of Nphs2, Podxl, and Nphs1 were reduced in podocyte-specific Crb2 knockout mice compared to negative control mice.
8	34654837	Crb2 is a cell polarity-related type I transmembrane protein expressed in the apical membrane of podocytes.
9	34654837	The number of glomerular Wt1-positive cells and the expressions of Nphs2, Podxl, and Nphs1 were reduced in podocyte-specific Crb2 knockout mice compared to negative control mice.