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Gene Information
Gene symbol: CSNK2A1
Gene name: casein kinase 2, alpha 1 polypeptide
HGNC ID: 2457
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NPHS1 | 1 hits |
| 2 | PACSIN2 | 1 hits |
| 3 | PRKCA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 28550045 | PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease. |
| 2 | 28550045 | Here, we investigate the role of protein kinase C and casein kinase 2 substrate in neurons 2 (PACSIN2), a regulator of endocytosis and recycling, in the trafficking of nephrin and development of DKD. |
| 3 | 28550045 | We observe that PACSIN2 is up-regulated and nephrin mislocalized in podocytes of obese Zucker diabetic fatty (ZDF) rats that have altered renal function. |
| 4 | 28550045 | In cultured podocytes, PACSIN2 and nephrin colocalize and interact. |
| 5 | 28550045 | We show that nephrin is endocytosed in PACSIN2-positive membrane regions and that PACSIN2 overexpression increases both nephrin endocytosis and recycling. |
| 6 | 28550045 | We identify rabenosyn-5, which is involved in early endosome maturation and endosomal sorting, as a novel interaction partner of PACSIN2. |
| 7 | 28550045 | Interestingly, rabenosyn-5 expression is increased in podocytes in obese ZDF rats, and, in vitro, its overexpression enhances the association of PACSIN2 and nephrin. |
| 8 | 28550045 | Collectively, PACSIN2 is up-regulated and nephrin is abnormally localized in podocytes of diabetic ZDF rats. |
| 9 | 28550045 | In vitro, PACSIN2 enhances nephrin turnover apparently via a mechanism involving rabenosyn-5. |
| 10 | 28550045 | The data suggest that elevated PACSIN2 expression accelerates nephrin trafficking and associates with albuminuria. |