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Gene Information
Gene symbol: CXCL1
Gene name: chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
HGNC ID: 4602
Synonyms: SCYB1, GROa, MGSA-a, NAP-3
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACTN4 | 1 hits |
| 2 | ALB | 1 hits |
| 3 | CCL2 | 1 hits |
| 4 | CXCL2 | 1 hits |
| 5 | DDIT3 | 1 hits |
| 6 | DMPK | 1 hits |
| 7 | HSPB1 | 1 hits |
| 8 | IL6 | 1 hits |
| 9 | PTGS2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 23235477 | Unexpectedly, while Toll-like receptor 4 (TLR4) expression levels were comparable in kidneys of CHOP(-/-) and wild-type (WT) mice, CHOP(-/-) mice developed more severe AKI after LPS injection. |
| 2 | 23235477 | Additionally, the kidneys of LPS-treated CHOP(-/-) mice had a more prominent increase in NF-κB activation and further upregulation of proinflammatory genes, i.e., c-x-c motif ligand 1 (CXCL-1), macrophage inflammatory protein-2 (MIP-2), and IL-6. |
| 3 | 24918154 | Albumin-induced podocyte injury and protection are associated with regulation of COX-2. |
| 4 | 24918154 | Here in vivo and in vitro models of serum albumin-overload were used to test the hypothesis that albumin-induced proteinuria and podocyte injury directly correlate with COX-2 induction. |
| 5 | 24918154 | Albumin induced COX-2, MCP-1, CXCL1, and the stress protein HSP25 in both rat glomeruli and cultured podocytes, whereas B7-1 and HSP70i were also induced in podocytes. |
| 6 | 24918154 | Podocyte exposure to albumin induced both mRNA and protein and enhanced the mRNA stability of COX-2, a key regulator of renal hemodynamics and inflammation, which renders podocytes susceptible to injury. |
| 7 | 24918154 | Podocyte exposure to albumin also stimulated several kinases (p38 MAPK, MK2, JNK/SAPK, and ERK1/2), inhibitors of which (except JNK/SAPK) downregulated albumin-induced COX-2. |
| 8 | 24918154 | Inhibition of AMPK, PKC, and NFκB also downregulated albumin-induced COX-2. |
| 9 | 24918154 | Critically, albumin-induced COX-2 was also inhibited by glucocorticoids and thiazolidinediones, both of which directly protect podocytes against injury. |
| 10 | 24918154 | Furthermore, specific albumin-associated fatty acids were identified as important contributors to COX-2 induction, podocyte injury, and proteinuria. |
| 11 | 24918154 | Moreover, COX-2 induction, podocyte damage, and albuminuria appear mediated largely by serum albumin-associated fatty acids. |
| 12 | 24940801 | We expressed enhanced green fluorescent protein-tagged to ribosomal protein L10a in podocytes under the control of the collagen-1α1 promoter, enabling one-step podocyte-specific mRNA isolation over the course of disease. |
| 13 | 24940801 | Two upregulated podocyte genes in murine FSGS (CXCL1 and DMPK) were found to be upregulated at the protein level in biopsies from patients with FSGS, validating this approach. |