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Gene Information
Gene symbol: CXXC5
Gene name: CXXC finger protein 5
HGNC ID: 26943
Synonyms: HSPC195, RINF, WID
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CTNNB1 | 1 hits |
| 2 | JUP | 1 hits |
| 3 | WT1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 20220130 | Mammalian kidney development requires the functions of the Wilms tumor gene WT1 and the WNT/beta-catenin signaling pathway. |
| 2 | 20220130 | Recent studies have shown that WT1 negatively regulates WNT/beta-catenin signaling, but the molecular mechanisms by which WT1 inhibits WNT/beta-catenin signaling are not completely understood. |
| 3 | 20220130 | In this study, we identified a gene, CXXC5, which we have renamed WID (WT1-induced Inhibitor of Dishevelled), as a novel WT1 transcriptional target that negatively regulates WNT/beta-catenin signaling. |
| 4 | 20220130 | Structure-function analysis demonstrated that WID interacts with Dishevelled via its C-terminal CXXC zinc finger and Dishevelled binding domains and potently inhibits WNT/beta-catenin signaling in vitro and in vivo. |
| 5 | 20220130 | Taken together, our results demonstrate that the WT1 negatively regulates WNT/beta-catenin pathway via its target gene WID and further suggest a role for WID in nephrogenesis. |